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82. Abubackar HN, Veiga MC, Kennes C (2015) Carbon monoxide fermentation to ethanol by
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83. Mock J, Zheng Y, Müller AP, Ly S, Tran L, Segovia S, Nagaraju S, Köpke M, Dürre P,
Thauer RK (2015) Energy conservation associated with ethanol formation from H 2 and CO 2
in Clostridium autoethanogenum involving electron bifurcation. J Bacteriol 197:2965–2980
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1172
66. Ergal I, Fuchs W, Hasibar B, Thallinger B, Bochmann G, Rittmann SKMR (2018) The
physiology and biotechnology of dark fermentative biohydrogen production. Biotechnol
Adv 36:2165–2186
67. Kottenhahn P, Schuchmann K, Müller V (2018) Efficient whole cell biocatalyst for
formate-based hydrogen production. Biotechnol Biofuels 11:93
68. Rittmann S, Herwig C (2012) A comprehensive and quantitative review of dark fermentative
biohydrogen production. Microb Cell Fact 11:115
69. Rittmann SK, Lee HS, Lim JK, Kim TW, Lee JH, Kang SG (2015) One-carbon
substrate-based biohydrogen production: microbes, mechanism, and productivity. Biotechnol Adv 33:165–177
70. Weghoff MC, Müller V (2016) CO metabolism in the thermophilic acetogen Thermoanaerobacter kivui. Appl Environ Microbiol 82:2312–2319
71. Bertsch J, Müller V (2015a) CO metabolism in the acetogen Acetobacterium woodii. Appl
Environ Microbiol 81:5949–5956
72. Bertsch J, Müller V (2015b) Bioenergetic constraints for conversion of syngas to biofuels in
acetogenic bacteria. Biotechnol Biofuels 8:210
73. Taylor MP, Eley KL, Martin S, Tuffin MI, Burton SG, Cowan DA (2009) Thermophilic
ethanologenesis: future prospects for second-generation bioethanol production. Trends
Biotechnol 27:398–405
74. Schwarz FM, Müller V (2020) Whole-cell biocatalysis for hydrogen storage and syngas
conversion to formate using a thermophilic acetogen. Biotechnol Biofuels 13:32
75. Jung HC, Lee SH, Lee SM, An YJ, Lee JH, Lee HS, Kang SG (2017) Adaptive evolution of
a hyperthermophilic archaeon pinpoints a formate transporter as a critical factor for the
growth enhancement on formate. Sci Rep 7:6124
76. Lim JK, Bae SS, Kim TW, Lee JH, Lee HS, Kang SG (2012) Thermodynamics of
formate-oxidizing metabolism and implications for H 2 production. Appl Environ Microbiol
78:7393–7397
77. Kim YJ, Lee HS, Kim ES, Bae SS, Lim JK, Matsumi R, Lebedinsky AV, Sokolova TG,
Kozhevnikova DA, Cha SS, Kim SJ, Kwon KK, Imanaka T, Atomi H,
Bonch-Osmolovskaya EA, Lee JH, Kang SG (2010) Formate-driven growth coupled with
H 2 production. Nature 467:352–355
78. Lim JK, Mayer F, Kang SG, Müller V (2014) Energy conservation by oxidation of formate
to carbon dioxide and hydrogen via a sodium ion current in a hyperthermophilic archaeon.
Proc Natl Acad Sci USA 111:11497–11502
79. Heffernan JK, Valgepea K, de Souza Pinto Lemgruber R, Casini I, Plan M, Tappel R,
Simpson SD, Köpke M, Nielsen LK, Marcellin E (2020) Enhancing CO 2 -valorization using
Clostridium autoethanogenum for sustainable fuel and chemicals production. Front Bioeng
Biotechnol 204
80. Abrini J, Naveau H, Nyns EJ (1994) Clostridium autoethanogenum, sp. nov., an anaerobic
bacterium that produces ethanol from carbon monoxide. Arch Microbiol 161:345–351
81. Köpke M, Mihalcea C, Liew F, Tizard JH, Ali MS, Conolly JJ, Al-Sinawi B, Simpson SD
(2011) 2,3-butanediol production by acetogenic bacteria, an alternative route to chemical
synthesis, using industrial waste gas. Appl Environ Microbiol 77:5467–5475
82. Abubackar HN, Veiga MC, Kennes C (2015) Carbon monoxide fermentation to ethanol by
Clostridium autoethanogenum in a bioreactor with no accumulation of acetic acid. Bioresour
Technol 186:122–127
83. Mock J, Zheng Y, Müller AP, Ly S, Tran L, Segovia S, Nagaraju S, Köpke M, Dürre P,
Thauer RK (2015) Energy conservation associated with ethanol formation from H 2 and CO 2
in Clostridium autoethanogenum involving electron bifurcation. J Bacteriol 197:2965–2980
84. Celinska E, Grajek W (2009) Biotechnological production of 2,3-butanediol-Current state
and prospects. Biotechnol Adv 27:715–725
128
D. Litty and V. Müller