Commun 7:11529. https://doi.org/10.
1038/ncomms11529
34. Barsoum J, Brown R, McKee M et al (1997)
Efficient transduction of mammalian cells by a
recombinant baculovirus having the vesicular
stomatitis virus G glycoprotein. Hum Gene
Ther 8(17):2011–2018. https://doi.org/10.
1089/hum.1997.8.17-2011
35. Li Y, Yang Y, Wang S (2005) Neuronal gene
transfer by baculovirus-derived vectors
accommodating a neurone-specific promoter.
Exp Physiol 90(1):39–44. https://doi.org/
10.1113/expphysiol.2004.028217
36. Wang CY, Wang S (2006) Astrocytic expression of transgene in the rat brain mediated by
baculovirus vectors containing an astrocytespecific
promoter.
Gene
Ther
13
(20):1447–1456. https://doi.org/10.1038/
sj.gt.3302771
37. Boyce FM, Bucher NL (1996) Baculovirusmediated gene transfer into mammalian cells.
Proc Natl Acad Sci U S A 93(6):2348–2352.
https://doi.org/10.1073/pnas.93.6.2348
38. Shoji I, Aizaki H, Tani H et al (1997) Efficient
gene transfer into various mammalian cells,
including non-hepatic cells, by baculovirus
vectors. J Gen Virol 78(Pt 10):2657–2664.
https://doi.org/10.1099/0022-1317-7810-2657
39. M€ aho ¨nen AJ, Airenne KJ, Purola S et al
(2007) Post-transcriptional regulatory element boosts baculovirus-mediated gene
expression in vertebrate cells. J Biotechnol
131(1):1–8.
https://doi.org/10.1016/j.
jbiotec.2007.05.022
40. Ang WX, Zhao Y, Kwang T et al (2016) Local
immune stimulation by Intravesical instillation of baculovirus to enable bladder cancer
therapy. Sci Rep 6:27455. https://doi.org/
10.1038/srep27455
41. Lykhova AA, Kudryavets YI, Strokovska LI
et al (2015) Suppression of proliferation,
tumorigenicity and metastasis of lung cancer
cells after their transduction by interferonbeta gene in baculovirus vector. Cytokine 71
(2):318–326.
https://doi.org/10.1016/j.
cyto.2014.10.029
42. Swift SL, Rivera GC, Dussupt V et al (2013)
Evaluating baculovirus as a vector for human
prostate cancer gene therapy. PLoS One 8(6):
e65557. https://doi.org/10.1371/journal.
pone.0065557
43. Wang C-Y, Li F, Yang Y et al (2006) Recombinant baculovirus containing the diphtheria
toxin A gene for malignant glioma therapy.
Cancer Res 66(11):5798–5806. https://doi.
org/10.1158/0008-5472.CAN-05-4514
44. Lin C-Y, Chang Y-H, Kao C-Y et al (2012)
Augmented healing of critical-size calvarial
defects by baculovirus-engineered MSCs that
persistently express growth factors. Biomaterials 33(14):3682–3692. https://doi.org/10.
1016/j.biomaterials.2012.02.007
45. Lin C-Y, Lin K-J, Kao C-Y et al (2011) The
role of adipose-derived stem cells engineered
with the persistently expressing hybrid baculovirus in the healing of massive bone defects.
Biomaterials 32(27):6505–6514. https://
doi.org/10.1016/j.biomaterials.2011.05.
059
46. Lin C-Y, Lin K-J, Li K-C et al (2012) Immune
responses during healing of massive segmental
femoral bone defects mediated by hybrid
baculovirus-engineered ASCs. Biomaterials
33(30):7422–7434.
https://doi.org/10.
1016/j.biomaterials.2012.06.083
47. Lu C-H, Yeh T-S, Yeh C-L et al (2014)
Regenerating cartilages by engineered ASCs:
prolonged
TGF-β3/BMP-6
expression
improved articular cartilage formation and
restored zonal structure. Mol Ther 22
(1):186–195. https://doi.org/10.1038/mt.
2013.165
48. Hu Y-C, Yao K, Wu T-Y (2008) Baculovirus
as an expression and/or delivery vehicle for
vaccine antigens. Expert Rev Vaccines 7
(3):363–371.
https://doi.org/10.1586/
14760584.7.3.363
49. Lu H-Y, Chen Y-H, Liu H-J (2012) Baculovirus as a vaccine vector. Bioengineered 3
(5):271–274.
https://doi.org/10.4161/
bioe.20679
50. Madhan S, Prabakaran M, Kwang J (2010)
Baculovirus as vaccine vectors. Curr Gene
Ther 10(3):201–213
51. Yong S-B, Chung JY, Song Y et al (2018)
Recent challenges and advances in
genetically-engineered cell therapy. J Pharm
Investig 48(2):199–208. https://doi.org/
10.1007/s40005-017-0381-1
52. Castro-Manrreza ME, Montesinos JJ (2015)
Immunoregulation by mesenchymal stem
cells: biological aspects and clinical applications. J Immunol Res 2015:394917.
https://doi.org/10.1155/2015/394917
53. Andrzejewska A, Lukomska B, Janowski M
(2019) Concise review: mesenchymal stem
cells: from roots to boost. Stem Cells 37
(7):855–864.
https://doi.org/10.1002/
stem.3016
54. Brown C, McKee C, Bakshi S et al (2019)
Mesenchymal stem cells: cell therapy and
regeneration potential. J Tissue Eng Regen
Baculovirus-Mediated Gene Transfer to Stem Cells
387
1038/ncomms11529
34. Barsoum J, Brown R, McKee M et al (1997)
Efficient transduction of mammalian cells by a
recombinant baculovirus having the vesicular
stomatitis virus G glycoprotein. Hum Gene
Ther 8(17):2011–2018. https://doi.org/10.
1089/hum.1997.8.17-2011
35. Li Y, Yang Y, Wang S (2005) Neuronal gene
transfer by baculovirus-derived vectors
accommodating a neurone-specific promoter.
Exp Physiol 90(1):39–44. https://doi.org/
10.1113/expphysiol.2004.028217
36. Wang CY, Wang S (2006) Astrocytic expression of transgene in the rat brain mediated by
baculovirus vectors containing an astrocytespecific
promoter.
Gene
Ther
13
(20):1447–1456. https://doi.org/10.1038/
sj.gt.3302771
37. Boyce FM, Bucher NL (1996) Baculovirusmediated gene transfer into mammalian cells.
Proc Natl Acad Sci U S A 93(6):2348–2352.
https://doi.org/10.1073/pnas.93.6.2348
38. Shoji I, Aizaki H, Tani H et al (1997) Efficient
gene transfer into various mammalian cells,
including non-hepatic cells, by baculovirus
vectors. J Gen Virol 78(Pt 10):2657–2664.
https://doi.org/10.1099/0022-1317-7810-2657
39. M€ aho ¨nen AJ, Airenne KJ, Purola S et al
(2007) Post-transcriptional regulatory element boosts baculovirus-mediated gene
expression in vertebrate cells. J Biotechnol
131(1):1–8.
https://doi.org/10.1016/j.
jbiotec.2007.05.022
40. Ang WX, Zhao Y, Kwang T et al (2016) Local
immune stimulation by Intravesical instillation of baculovirus to enable bladder cancer
therapy. Sci Rep 6:27455. https://doi.org/
10.1038/srep27455
41. Lykhova AA, Kudryavets YI, Strokovska LI
et al (2015) Suppression of proliferation,
tumorigenicity and metastasis of lung cancer
cells after their transduction by interferonbeta gene in baculovirus vector. Cytokine 71
(2):318–326.
https://doi.org/10.1016/j.
cyto.2014.10.029
42. Swift SL, Rivera GC, Dussupt V et al (2013)
Evaluating baculovirus as a vector for human
prostate cancer gene therapy. PLoS One 8(6):
e65557. https://doi.org/10.1371/journal.
pone.0065557
43. Wang C-Y, Li F, Yang Y et al (2006) Recombinant baculovirus containing the diphtheria
toxin A gene for malignant glioma therapy.
Cancer Res 66(11):5798–5806. https://doi.
org/10.1158/0008-5472.CAN-05-4514
44. Lin C-Y, Chang Y-H, Kao C-Y et al (2012)
Augmented healing of critical-size calvarial
defects by baculovirus-engineered MSCs that
persistently express growth factors. Biomaterials 33(14):3682–3692. https://doi.org/10.
1016/j.biomaterials.2012.02.007
45. Lin C-Y, Lin K-J, Kao C-Y et al (2011) The
role of adipose-derived stem cells engineered
with the persistently expressing hybrid baculovirus in the healing of massive bone defects.
Biomaterials 32(27):6505–6514. https://
doi.org/10.1016/j.biomaterials.2011.05.
059
46. Lin C-Y, Lin K-J, Li K-C et al (2012) Immune
responses during healing of massive segmental
femoral bone defects mediated by hybrid
baculovirus-engineered ASCs. Biomaterials
33(30):7422–7434.
https://doi.org/10.
1016/j.biomaterials.2012.06.083
47. Lu C-H, Yeh T-S, Yeh C-L et al (2014)
Regenerating cartilages by engineered ASCs:
prolonged
TGF-β3/BMP-6
expression
improved articular cartilage formation and
restored zonal structure. Mol Ther 22
(1):186–195. https://doi.org/10.1038/mt.
2013.165
48. Hu Y-C, Yao K, Wu T-Y (2008) Baculovirus
as an expression and/or delivery vehicle for
vaccine antigens. Expert Rev Vaccines 7
(3):363–371.
https://doi.org/10.1586/
14760584.7.3.363
49. Lu H-Y, Chen Y-H, Liu H-J (2012) Baculovirus as a vaccine vector. Bioengineered 3
(5):271–274.
https://doi.org/10.4161/
bioe.20679
50. Madhan S, Prabakaran M, Kwang J (2010)
Baculovirus as vaccine vectors. Curr Gene
Ther 10(3):201–213
51. Yong S-B, Chung JY, Song Y et al (2018)
Recent challenges and advances in
genetically-engineered cell therapy. J Pharm
Investig 48(2):199–208. https://doi.org/
10.1007/s40005-017-0381-1
52. Castro-Manrreza ME, Montesinos JJ (2015)
Immunoregulation by mesenchymal stem
cells: biological aspects and clinical applications. J Immunol Res 2015:394917.
https://doi.org/10.1155/2015/394917
53. Andrzejewska A, Lukomska B, Janowski M
(2019) Concise review: mesenchymal stem
cells: from roots to boost. Stem Cells 37
(7):855–864.
https://doi.org/10.1002/
stem.3016
54. Brown C, McKee C, Bakshi S et al (2019)
Mesenchymal stem cells: cell therapy and
regeneration potential. J Tissue Eng Regen
Baculovirus-Mediated Gene Transfer to Stem Cells
387