12. Vail PV, Sutter G, Jay DL et al (1971) Reciprocal infectivity of nuclear polyhedrosis
viruses of the cabbage looper and alfalfa
looper. J Invertebr Pathol 17(3):383–388.
https://doi.org/10.1016/0022-2011(71)
90013-9
13. Summers MD (2006) Milestones leading to
the genetic engineering of baculoviruses as
expression vector systems and viral pesticides.
In: Bonning BC (ed) Insect viruses: biotechnological applications, vol 68. Elsevier Academic Press, Amsterdam, pp 3–73
14. Cox MMJ, Hashimoto Y (2011) A fast track
influenza virus vaccine produced in insect
cells. J Invertebr Pathol 107(Suppl):
S31–S41.
https://doi.org/10.1016/j.jip.
2011.05.003
15. Mena JA, Kamen AA (2011) Insect cell technology is a versatile and robust vaccine
manufacturing platform. Expert Rev Vaccines
10(7):1063–1081.
https://doi.org/10.
1586/erv.11.24
16. Lin S-Y, Chung Y-C, Hu Y-C (2014) Update
on baculovirus as an expression and/or delivery vehicle for vaccine antigens. Expert Rev
Vaccines 13(12):1501–1521. https://doi.
org/10.1586/14760584.2014.951637
17. Hofmann C, Sandig V, Jennings G et al
(1995) Efficient gene transfer into human
hepatocytes by baculovirus vectors. Proc
Natl Acad Sci U S A 92(22):10099–10103.
https://doi.org/10.1073/pnas.92.22.
10099
18. Chen C-Y, Lin C-Y, Chen G-Y et al (2011)
Baculovirus as a gene delivery vector: recent
understandings of molecular alterations in
transduced cells and latest applications. Biotechnol Adv 29(6):618–631. https://doi.
org/10.1016/j.biotechadv.2011.04.004
19. Cheng T, Xu C-Y, Wang Y-B et al (2004) A
rapid and efficient method to express target
genes in mammalian cells by baculovirus.
World J Gastroenterol 10(11):1612–1618.
https://doi.org/10.3748/wjg.v10.i11.1612
20. Condreay JP, Witherspoon SM, Clay WC et al
(1999) Transient and stable gene expression
in mammalian cells transduced with a recombinant baculovirus vector. Proc Natl Acad Sci
U S A 96(1):127–132. https://doi.org/10.
1073/pnas.96.1.127
21. Kost TA, Condreay JP (2002) Recombinant
baculoviruses as mammalian cell genedelivery vectors. Trends Biotechnol 20
(4):173–180
22. Hu Y-C (2008) Baculoviral vectors for gene
delivery: a review. Curr Gene Ther 8
(1):54–65
23. Cheshenko N, Krougliak N, Eisensmith RC
et al (2001) A novel system for the production
of fully deleted adenovirus vectors that does
not require helper adenovirus. Gene Ther 8
(11):846–854. https://doi.org/10.1038/sj.
gt.3301459
24. Kost TA, Condreay JP, Jarvis DL (2005)
Baculovirus as versatile vectors for protein
expression in insect and mammalian cells.
Nat Biotechnol 23(5):567–575. https://doi.
org/10.1038/nbt1095
25. Wang K-C, Wu J-C, Chung Y-C et al (2005)
Baculovirus as a highly efficient gene delivery
vector for the expression of hepatitis delta
virus antigens in mammalian cells. Biotechnol
Bioeng 89(4):464–473. https://doi.org/10.
1002/bit.20385
26. Merrihew RV, Clay WC, Condreay JP et al
(2001) Chromosomal integration of transduced recombinant baculovirus DNA in
mammalian cells. J Virol 75(2):903–909.
https://doi.org/10.1128/JVI.75.2.903909.2001
27. Luo W-Y, Lin S-Y, Lo K-W et al (2013) Adaptive immune responses elicited by baculovirus
and impacts on subsequent transgene expression in vivo. J Virol 87(9):4965–4973.
https://doi.org/10.1128/JVI.03510-12
28. Strauss R, Hu ¨ser A, Ni S et al (2007)
Baculovirus-based vaccination vectors allow
for efficient induction of immune responses
against Plasmodium falciparum circumsporozoite protein. Mol Ther 15(1):193–202.
https://doi.org/10.1038/sj.mt.6300008
29. Murhammer DW (ed) (2007) Baculovirus
and insect cell expression protocols, Methods
in molecular biology, vol 388, 2nd edn.
Humana Press, Totowa, NJ
30. Jorio H, Tran R, Kamen A (2006) Stability of
serum-free and purified baculovirus stocks
under various storage conditions. Biotechnol
Prog 22(1):319–325. https://doi.org/10.
1021/bp050218v
31. Pan Y, Zhao Q, Fang L et al (2009) Efficient
gene delivery into mammalian cells by recombinant baculovirus containing a hybrid cytomegalovirus promoter/Semliki Forest virus
replicon. J Gene Med 11(11):1030–1038.
https://doi.org/10.1002/jgm.1390
32. Tani H, Nishijima M, Ushijima H et al (2001)
Characterization of cell-surface determinants
important for baculovirus infection. Virology
279(1):343–353. https://doi.org/10.1006/
viro.2000.0699
33. Mansouri M, Bellon-Echeverria I, Rizk A et al
(2016) Highly efficient baculovirus-mediated
multigene delivery in primary cells. Nat
386
Friederike Eilts et al.
viruses of the cabbage looper and alfalfa
looper. J Invertebr Pathol 17(3):383–388.
https://doi.org/10.1016/0022-2011(71)
90013-9
13. Summers MD (2006) Milestones leading to
the genetic engineering of baculoviruses as
expression vector systems and viral pesticides.
In: Bonning BC (ed) Insect viruses: biotechnological applications, vol 68. Elsevier Academic Press, Amsterdam, pp 3–73
14. Cox MMJ, Hashimoto Y (2011) A fast track
influenza virus vaccine produced in insect
cells. J Invertebr Pathol 107(Suppl):
S31–S41.
https://doi.org/10.1016/j.jip.
2011.05.003
15. Mena JA, Kamen AA (2011) Insect cell technology is a versatile and robust vaccine
manufacturing platform. Expert Rev Vaccines
10(7):1063–1081.
https://doi.org/10.
1586/erv.11.24
16. Lin S-Y, Chung Y-C, Hu Y-C (2014) Update
on baculovirus as an expression and/or delivery vehicle for vaccine antigens. Expert Rev
Vaccines 13(12):1501–1521. https://doi.
org/10.1586/14760584.2014.951637
17. Hofmann C, Sandig V, Jennings G et al
(1995) Efficient gene transfer into human
hepatocytes by baculovirus vectors. Proc
Natl Acad Sci U S A 92(22):10099–10103.
https://doi.org/10.1073/pnas.92.22.
10099
18. Chen C-Y, Lin C-Y, Chen G-Y et al (2011)
Baculovirus as a gene delivery vector: recent
understandings of molecular alterations in
transduced cells and latest applications. Biotechnol Adv 29(6):618–631. https://doi.
org/10.1016/j.biotechadv.2011.04.004
19. Cheng T, Xu C-Y, Wang Y-B et al (2004) A
rapid and efficient method to express target
genes in mammalian cells by baculovirus.
World J Gastroenterol 10(11):1612–1618.
https://doi.org/10.3748/wjg.v10.i11.1612
20. Condreay JP, Witherspoon SM, Clay WC et al
(1999) Transient and stable gene expression
in mammalian cells transduced with a recombinant baculovirus vector. Proc Natl Acad Sci
U S A 96(1):127–132. https://doi.org/10.
1073/pnas.96.1.127
21. Kost TA, Condreay JP (2002) Recombinant
baculoviruses as mammalian cell genedelivery vectors. Trends Biotechnol 20
(4):173–180
22. Hu Y-C (2008) Baculoviral vectors for gene
delivery: a review. Curr Gene Ther 8
(1):54–65
23. Cheshenko N, Krougliak N, Eisensmith RC
et al (2001) A novel system for the production
of fully deleted adenovirus vectors that does
not require helper adenovirus. Gene Ther 8
(11):846–854. https://doi.org/10.1038/sj.
gt.3301459
24. Kost TA, Condreay JP, Jarvis DL (2005)
Baculovirus as versatile vectors for protein
expression in insect and mammalian cells.
Nat Biotechnol 23(5):567–575. https://doi.
org/10.1038/nbt1095
25. Wang K-C, Wu J-C, Chung Y-C et al (2005)
Baculovirus as a highly efficient gene delivery
vector for the expression of hepatitis delta
virus antigens in mammalian cells. Biotechnol
Bioeng 89(4):464–473. https://doi.org/10.
1002/bit.20385
26. Merrihew RV, Clay WC, Condreay JP et al
(2001) Chromosomal integration of transduced recombinant baculovirus DNA in
mammalian cells. J Virol 75(2):903–909.
https://doi.org/10.1128/JVI.75.2.903909.2001
27. Luo W-Y, Lin S-Y, Lo K-W et al (2013) Adaptive immune responses elicited by baculovirus
and impacts on subsequent transgene expression in vivo. J Virol 87(9):4965–4973.
https://doi.org/10.1128/JVI.03510-12
28. Strauss R, Hu ¨ser A, Ni S et al (2007)
Baculovirus-based vaccination vectors allow
for efficient induction of immune responses
against Plasmodium falciparum circumsporozoite protein. Mol Ther 15(1):193–202.
https://doi.org/10.1038/sj.mt.6300008
29. Murhammer DW (ed) (2007) Baculovirus
and insect cell expression protocols, Methods
in molecular biology, vol 388, 2nd edn.
Humana Press, Totowa, NJ
30. Jorio H, Tran R, Kamen A (2006) Stability of
serum-free and purified baculovirus stocks
under various storage conditions. Biotechnol
Prog 22(1):319–325. https://doi.org/10.
1021/bp050218v
31. Pan Y, Zhao Q, Fang L et al (2009) Efficient
gene delivery into mammalian cells by recombinant baculovirus containing a hybrid cytomegalovirus promoter/Semliki Forest virus
replicon. J Gene Med 11(11):1030–1038.
https://doi.org/10.1002/jgm.1390
32. Tani H, Nishijima M, Ushijima H et al (2001)
Characterization of cell-surface determinants
important for baculovirus infection. Virology
279(1):343–353. https://doi.org/10.1006/
viro.2000.0699
33. Mansouri M, Bellon-Echeverria I, Rizk A et al
(2016) Highly efficient baculovirus-mediated
multigene delivery in primary cells. Nat
386
Friederike Eilts et al.