References
1. Bhambure R, Rathore A (2013) Chromatography process development in the quality by
design paradigm I: establishing a highthroughput process development platform as
a tool for estimating “characterization space”
for an ion exchange chromatography step. Biotechnol Prog 29:403–414
2. Daniels C, Rodriguez J, Lim E et al (2016) An
integrated robotic system for high-throughput
process development of cell and virus culture
conditions: application to biosafety level 2 live
virus vaccines. Eng Life Sci 16:202–209
3. Wenger MD, Dephillips P, Price CE et al
(2007) An automated microscale chromatographic purification of virus-like particles
as a strategy for process development. Biotechnol Appl Biochem 47:131–139
4. Konstantinidis S, Welsh JP, Roush DJ et al
(2016) Application of simplex-based experimental optimization to challenging bioprocess
development problems: case studies in downstream
processing.
Biotechnol
Prog
32:404–419
5. Konstantinidis S, Welsh JP, Titchener-Hooker
NJ et al (2018) Data-driven multi-objective
optimization via grid compatible simplex technique and desirability approach for challenging
high throughput chromatography applications.
Biotechnol Prog 34:1393–1406
HTPD Purification of Viral Antigens
181
1. Bhambure R, Rathore A (2013) Chromatography process development in the quality by
design paradigm I: establishing a highthroughput process development platform as
a tool for estimating “characterization space”
for an ion exchange chromatography step. Biotechnol Prog 29:403–414
2. Daniels C, Rodriguez J, Lim E et al (2016) An
integrated robotic system for high-throughput
process development of cell and virus culture
conditions: application to biosafety level 2 live
virus vaccines. Eng Life Sci 16:202–209
3. Wenger MD, Dephillips P, Price CE et al
(2007) An automated microscale chromatographic purification of virus-like particles
as a strategy for process development. Biotechnol Appl Biochem 47:131–139
4. Konstantinidis S, Welsh JP, Roush DJ et al
(2016) Application of simplex-based experimental optimization to challenging bioprocess
development problems: case studies in downstream
processing.
Biotechnol
Prog
32:404–419
5. Konstantinidis S, Welsh JP, Titchener-Hooker
NJ et al (2018) Data-driven multi-objective
optimization via grid compatible simplex technique and desirability approach for challenging
high throughput chromatography applications.
Biotechnol Prog 34:1393–1406
HTPD Purification of Viral Antigens
181
