University of Copenhagen, Denmark, and colleagues describe the development
of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca
2+ ATPase), with potential as a
lead compound to treat cancer. The third chapter was written by a team headed by
Prof. Miroslav Strnad, of the Czech Academy of Sciences, Institute of Experimental
Botany, and Palacký University, Olomouc, Czech Republic. This covers the
potential of various plant phenolic compounds for treating the tropical and
sub-tropical infectious disease, leishmaniasis. In the final chapter, Dr. Steven
Shnyder and Prof. Colin Wright, of the University of Bradford, U.K. describe
recent advances on the plant alkaloid, cryptolepine, which is of particular interest as
a lead for the treatment of malaria, trypanosomiasis, and cancer.
Columbus, OH, USA
Douglas Kinghorn
Linz, Austria
Heinz Falk
Norwich, UK
Simon Gibbons
Tokushima, Japan
Yoshinori Asakawa
Wuhan, China
Ji-Kai Liu
vi
Preface
of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca
2+ ATPase), with potential as a
lead compound to treat cancer. The third chapter was written by a team headed by
Prof. Miroslav Strnad, of the Czech Academy of Sciences, Institute of Experimental
Botany, and Palacký University, Olomouc, Czech Republic. This covers the
potential of various plant phenolic compounds for treating the tropical and
sub-tropical infectious disease, leishmaniasis. In the final chapter, Dr. Steven
Shnyder and Prof. Colin Wright, of the University of Bradford, U.K. describe
recent advances on the plant alkaloid, cryptolepine, which is of particular interest as
a lead for the treatment of malaria, trypanosomiasis, and cancer.
Columbus, OH, USA
Douglas Kinghorn
Linz, Austria
Heinz Falk
Norwich, UK
Simon Gibbons
Tokushima, Japan
Yoshinori Asakawa
Wuhan, China
Ji-Kai Liu
vi
Preface