From Plant to Patient: Thapsigargin,
a Tool for Understanding Natural
Product Chemistry, Total Syntheses,
Biosynthesis, Taxonomy, ATPases, Cell
Death, and Drug Development
Søren Brøgger Christensen, Henrik Toft Simonsen, Nikolai Engedal,
Poul Nissen, Jesper Vuust Møller, Samuel R. Denmeade, and John T. Isaacs
S. B. Christensen (B)
Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2,
2100 Copenhagen Ø, Denmark
e-mail: soren.christensen@sund.ku.dk
H. T. Simonsen
Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads,
Bld 223, 2800 Kgs. Lyngby, Denmark
e-mail: hets@dtu.dk
N. Engedal
Department of Tumor Biology, Institute for Cancer Research, University Hospital, Montebello,
0379 Oslo, Norway
e-mail: nikolai.engedal@ncmm.uio.no
P. Nissen
Department of Molecular Biology and Genetics, Danish Research Institute of Translational
Neuroscience – DANDRITE, Nordic EMBL Partnership for Molecular Medicine, Aarhus
University, Gustav Wieds Vej 10C, 8000 Aarhus C, Denmark
e-mail: pn@mbg.au.dk
J. V. Møller
Department of Biomedicine, Aarhus University, Ole Worms Allé 3, Bld 1182, Room 114, 8000
Aarhus C, Denmark
e-mail: jvm@biomed.au.dk
S. R. Denmeade · J. T. Isaacs
Department of Oncology, Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer
Center at Johns Hopkins Maryland, The Johns Hopkins University School of Medicine,
Baltimore, The Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore,
MD 21231, USA
e-mail: denmesa@jhmi.edu
J. T. Isaacs
e-mail: isaacjo@jhmi.edu
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
A. D. Kinghorn, H. Falk, S. Gibbons, Y. Asakawa, J.-K. Liu, V. M. Dirsch (eds.),
Progress in the Chemistry of Organic Natural Products, Vol. 115,
https://doi.org/10.1007/978-3-030-64853-4_2
59