The Role of Total Synthesis in Structure …
51
25. Shelke AM, Suryavanshi G (2016) Formal synthesis of pinolide via l-proline-catalyzed
sequential α-aminooxylation, Horner–Wadsworth–Emmons olefination and Sharpless asymmetric dihydroxylation. Tetrahedron Asymmetry 27:142
26. Sperry JB, Minteer CJ, Tao J, Johnson R, Duzguner R, Hawksworth M, Oke S, Richardson PF,
Barnhart R, Bill DR, Giusto RA, Weaver JD (2018) Thermal stability assessment of peptide
coupling reagents commonly used in pharmaceutical manufacturing. Org Process Res Dev
22:1262
27. Tsakos M, Schaffert ES, Clement LL, Villadsen NL, Poulsen TB (2015) Ester coupling
reactions—an enduring challenge in the chemical synthesis of bioactive natural products.
Nat Prod Rep 32:605
28. Das T, Mahapatra T, Nanda S (2012) Total synthesis of stagonolide B. Tetrahedron Lett
53:1186
29. Ehrlich G, Stark CBW (2016) Total synthesis of cytospolide D and its biomimetic conversion
to cytospolides M, O, and Q. Org Lett 18:4802
30. Ehrlich G, Stark CBW (2019) Synthesis of cytospolide analogues and late-state diversification
thereof. J Org Chem 84:3132
31. Shiina I, Kubota M, Oshiumi H, Hashizume M (2004) An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: a powerful and
convenient mixed anhydride method promoted by basic catalysts. J Org Chem 69:1822
32. Deiters A, Martin SF (2004) Synthesis of oxygen- and nitrogen-containing heterocycles by
ring-closing metathesis. Chem Rev 104:2199
33. Schmidt B, Hauke S, Krehl S, Kunz O (2014) Ring closing metathesis. In: Molander GA,
Knochel P (eds) Comprehensive organic synthesis II, vol 5, 2nd edn. Elsevier, Amsterdam, p
1400
34. Schwab P, Grubbs RH, Ziller JW (1996) Synthesis and applications of RuCl 2 (=CHR’)(PR 3 ) 2 :
the influence of the alkylidene moiety on metathesis activity. J Am Chem Soc 118:100
35. Scholl M, Ding S, Lee CW, Grubbs RH (1999) Synthesis and activity of a new generation of ruthenium based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5dihydroimidazol-2-ylidene ligands. Org Lett 1:953
36. Schrock RR, Murdzek JS, Bazan GC, Robbins J, DiMare M, O’Regan M (1990) Synthesis
of Mo-imido alkylidene complexes and some reactions involving acyclic olefins. J Am Chem
Soc 112:3875
37. Schmidt B, Hermanns J (2004) Olefin metathesis directed to organic synthesis: principles and
applications. Top Organomet Chem 13:223
38. Mulzer J, Öhler E (2004) Diene, enyne, and diyne metathesis in natural product synthesis.
Top Organomet Chem 13:269
39. Fürstner A (2011) Metathesis in total synthesis. Chem Commun 47:6505
40. Gradillas A, Pérez-Castells J (2006) Macrocyclization by ring-closing metathesis in the total
synthesis of natural products: reaction conditions and limitations. Angew Chem Int Ed 45:6086
41. Han J-C, Li C-C (2015) Collective synthesis of natural products by using metathesis cascade
reactions. Synlett 26:1289
42. Nicolaou KC, Bulger PG, Sarlah D (2005) Metathesis reactions in total synthesis. Angew
Chem Int Ed 44:4490
43. Fürstner A, Müller T (1997) The first synthesis of a 10-membered ring by olefin metathesis:
jasmine ketolactone. Synlett 1010
44. Fu GC, Nguyen ST, Grubbs RH (1993) Catalytic ring-closing metathesis of functionalized
dienes by a ruthenium carbene complex. J Am Chem Soc 115:9856
45. Altmann KH, Höfle G, Müller R, Mulzer J, Prantz K (2009) The epothilones: an outstanding
family of antitumor agents. Prog Chem Org Nat Prod 90:1
46. Kalesse M, Quitschalle M, Claus E, Gerlach K, Pahl A, Meyer HH (1999) The formal total
synthesis of epothilone A. Eur J Org Chem 2817
47. Fürstner A, Radkowski K, Wirtz C, Goddard R, Lehmann CW, Mynott R (2002) Total
syntheses of the phytotoxic lactones herbarumin I and II and a synthesis-based solution of the
pinolidoxin puzzle. J Am Chem Soc 124:7061
51
25. Shelke AM, Suryavanshi G (2016) Formal synthesis of pinolide via l-proline-catalyzed
sequential α-aminooxylation, Horner–Wadsworth–Emmons olefination and Sharpless asymmetric dihydroxylation. Tetrahedron Asymmetry 27:142
26. Sperry JB, Minteer CJ, Tao J, Johnson R, Duzguner R, Hawksworth M, Oke S, Richardson PF,
Barnhart R, Bill DR, Giusto RA, Weaver JD (2018) Thermal stability assessment of peptide
coupling reagents commonly used in pharmaceutical manufacturing. Org Process Res Dev
22:1262
27. Tsakos M, Schaffert ES, Clement LL, Villadsen NL, Poulsen TB (2015) Ester coupling
reactions—an enduring challenge in the chemical synthesis of bioactive natural products.
Nat Prod Rep 32:605
28. Das T, Mahapatra T, Nanda S (2012) Total synthesis of stagonolide B. Tetrahedron Lett
53:1186
29. Ehrlich G, Stark CBW (2016) Total synthesis of cytospolide D and its biomimetic conversion
to cytospolides M, O, and Q. Org Lett 18:4802
30. Ehrlich G, Stark CBW (2019) Synthesis of cytospolide analogues and late-state diversification
thereof. J Org Chem 84:3132
31. Shiina I, Kubota M, Oshiumi H, Hashizume M (2004) An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: a powerful and
convenient mixed anhydride method promoted by basic catalysts. J Org Chem 69:1822
32. Deiters A, Martin SF (2004) Synthesis of oxygen- and nitrogen-containing heterocycles by
ring-closing metathesis. Chem Rev 104:2199
33. Schmidt B, Hauke S, Krehl S, Kunz O (2014) Ring closing metathesis. In: Molander GA,
Knochel P (eds) Comprehensive organic synthesis II, vol 5, 2nd edn. Elsevier, Amsterdam, p
1400
34. Schwab P, Grubbs RH, Ziller JW (1996) Synthesis and applications of RuCl 2 (=CHR’)(PR 3 ) 2 :
the influence of the alkylidene moiety on metathesis activity. J Am Chem Soc 118:100
35. Scholl M, Ding S, Lee CW, Grubbs RH (1999) Synthesis and activity of a new generation of ruthenium based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5dihydroimidazol-2-ylidene ligands. Org Lett 1:953
36. Schrock RR, Murdzek JS, Bazan GC, Robbins J, DiMare M, O’Regan M (1990) Synthesis
of Mo-imido alkylidene complexes and some reactions involving acyclic olefins. J Am Chem
Soc 112:3875
37. Schmidt B, Hermanns J (2004) Olefin metathesis directed to organic synthesis: principles and
applications. Top Organomet Chem 13:223
38. Mulzer J, Öhler E (2004) Diene, enyne, and diyne metathesis in natural product synthesis.
Top Organomet Chem 13:269
39. Fürstner A (2011) Metathesis in total synthesis. Chem Commun 47:6505
40. Gradillas A, Pérez-Castells J (2006) Macrocyclization by ring-closing metathesis in the total
synthesis of natural products: reaction conditions and limitations. Angew Chem Int Ed 45:6086
41. Han J-C, Li C-C (2015) Collective synthesis of natural products by using metathesis cascade
reactions. Synlett 26:1289
42. Nicolaou KC, Bulger PG, Sarlah D (2005) Metathesis reactions in total synthesis. Angew
Chem Int Ed 44:4490
43. Fürstner A, Müller T (1997) The first synthesis of a 10-membered ring by olefin metathesis:
jasmine ketolactone. Synlett 1010
44. Fu GC, Nguyen ST, Grubbs RH (1993) Catalytic ring-closing metathesis of functionalized
dienes by a ruthenium carbene complex. J Am Chem Soc 115:9856
45. Altmann KH, Höfle G, Müller R, Mulzer J, Prantz K (2009) The epothilones: an outstanding
family of antitumor agents. Prog Chem Org Nat Prod 90:1
46. Kalesse M, Quitschalle M, Claus E, Gerlach K, Pahl A, Meyer HH (1999) The formal total
synthesis of epothilone A. Eur J Org Chem 2817
47. Fürstner A, Radkowski K, Wirtz C, Goddard R, Lehmann CW, Mynott R (2002) Total
syntheses of the phytotoxic lactones herbarumin I and II and a synthesis-based solution of the
pinolidoxin puzzle. J Am Chem Soc 124:7061