Antileishmanial Activity of Lignans, Neolignans …
153
remodeling process (Fig. 19) [350]. In turn, dehydrodiconiferyl alcohol (148) showed
a capacity to inhibit osteoclast cell differentiation and therefore to enhance bone cell
formation [351, 352]. Sesamin (149) displayed promising activity on the chondrogenic differentiation of human mesenchymal stem cells that are useful in cartilage
regeneration [353].
O
OH
O
O
O
O
HO
O
O
HO
OH
OH
HO
O
HO
O
OH
OH
O
148 ((2S,3R)-dehydrodiconiferyl alcohol)
O
O
O
O
O
O
149 ((1S,3aR,4S,6aR)-sesamin)
O
O
O
OH
OH
OH
150 ((2S,3S)-americanin A)
O
O
O
O
O
(–)-151 (–)-(2R,3R,4S,5R)-zuonin A)
O
O
O
O
O
(+)-151 ((+)-(2S,3R,4S,5S)-zuonin A)
O
AcO
OAc
152 ((S)-galanganol D diacetate)
O
O
O
O
O
O
O
O
153 ((5S,6S,7S)-micratherin A)
O
O
O
O
O
O
154 ((6S,7R)-gomisin M2)
O
O
O
O
O
O
O
OH
O
156 ((5S,6S,7S)-angeloylgomisin R)
OH
O
O
O
O
O
O
O
O
157 ((6S,7R)-schisantherin A)
O
OCH3
OH
H3CO
HO
158 ((2R,3R,4S,5S)-nectandrin B)
145 (baicalensinoside A)
O
OH
O
O
O
HO
O
O
HO
OH
OH
HO
O
OH
O
O
HO
O
O
HO
OH
OH
HO
146 (baicalensinoside B)
147 (baicalensinoside C)
O
O
O
O
O
O
155 ((6S,7S)-schisandrin)
OH
Fig. 19 Selected lignans and neolignans with biological activity associated with protective ability
against osteoporosis, melanogenesis, and liver damage