106
S. B. Christensen et al.
101. Mikkelsen EO, Thastrup O, Christensen SB (1988) Effects of thapsigargin in isolated rat
thoracic aorta. Pharmacol Toxicol 62:7
102. Mikkelsen EO, Poulsen SH, Christensen SB (1992) Comparison of the effects of thapsigargin and BAY K 8644 on spontaneous mechanical activity in rat portal vein and contractile
responses of rat cardiac muscle. Pharmacol Toxicol 70:152
103. Kijima Y, Ogunbunmi E, Fleischer S (1991) Drug action of thapsigargin on the Ca 2+ pump
protein of sarcoplasmic reticulum. J Biol Chem 266:22912
104. Lytton J, Westlin M, Hanley MR (1991) Thapsigargin inhibits the sarcoplasmic or endoplasmic
reticulum Ca-ATPase family of calcium pumps. J Biol Chem 266:17067
105. Patkar SA, Rasmussen U, Diamant B (1979) On the mechanism of histamine release induced
by thapsigargin from Thapsia garganica L. Agents Actions 9:53
106. Ali H, Christensen SB, Foreman JC, Pearce FL, Piotrowski W, Thastrup O (1985) The ability
of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. Br
J Pharmacol 85:705
107. Shiraishi M, Hirasawa N, Kobayashi Y, Oikawa S, Murakami A, Ohuchi K (2000) Participation
of mitogen-activated protein kinase in thapsigargin- and TPA-induced histamine production
in murine macrophage RAW 264.7 cells. Br J Pharmacol 129:515
108. Furuya Y, Lundmo P, Short AD, Gill DL, Isaacs JT (1994) The role of calcium, pH, and cell
proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer
cells induced by thapsigargin. Cancer Res 54:6167
109. Lee WJ, Monteith GR, Roberts-Thomson J (2006) Calcium transport and signaling in the
mammary gland: targets for breast cancer. Biochim Biophys Acta Rev Cancer 1765:235
110. Monteith GR, McAndrew D, Faddy HM, Roberts-Thomson SJ (2007) Calcium and cancer:
targeting Ca 2+ transport. Nat Rev Cancer 7:519
111. Berna-Erro A, Jardin I, Salido GM, Rosado JA (2017) Role of STIM2 in cell function and
physiopathology. J Physiol 595:3111
112. Bong AHL, Monteith GR (2018) Calcium signaling and the therapeutic targeting of cancer
cells. Biochim Biophys Acta Mol Cell Res 1865B:1786
113. Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium
signalling. Nat Rev Mol Cell Biol 1:11
114. Stutzmann GE, Mattson MP (2011) Endoplasmic reticulum Ca 2+ handling in excitable cells
in health and disease. Pharmacol Rev 63:700
115. Wuytack F, Raeymaekers L, Missiaen L (2002) Molecular physiology of the SERCA and
SPCA pumps. Cell Calcium 32:279
116. Brini M, Carafoli E (2009) Calcium pumps in health and disease. Physiol Rev 89:1341
117. Palmgren MG, Nissen P (2011) P-type ATPases. Ann Rev Biophys 40:243
118. Mochly-Rosen D, Das K, Grimes KV (2012) Protein kinase C, an elusive therapeutic target?
Nat Rev Drug Discov 11:937
119. Krishna S, Zhong X-P (2013) Regulation of lipid signaling by diacylglycerol kinases during
T cell development and function. Front Immunol 2013:178
120. Smyth JT, DeHaven WI, Jones BF, Mercer JC, Trebak M, Vazquez G, Putney JW (2006)
Emerging perspectives in store-operated Ca 2+ entry: roles of Orai, Stim and TRP. Biochim
Biophys Acta Mol Cell Res 1763:1147
121. Ambudkar IS, de Souza LB, Ong HL (2017) TRPC1, Orai1, and STIM1 in SOCE: friends in
tight spaces. Cell Calcium 63:33
122. Chemaly ER, Troncone L, Lebeche D (2018) SERCA control of cell death and survival. Cell
Calcium 69:46
123. Yatime L, Buch-Pedersen MJ, Musgaard M, Morth JP, Lund Winther A-M, Pedersen BP,
Olesen C, Andersen JP, Vilsen B, Schioett B, Palmgren MG, Moeller JV, Nissen P, Fedosova
N (2009) P-type ATPases as drug targets: tools for medicine and science. Biochim Biophys
Acta Bioenerg 1787:207
124. Jun CD, Yoon HJ, Park YC, Lee SY, Kang SS, Kim HM, Chung HT (1996) Synergistic
cooperation between thapsigargin and phorbol ester for induction of nitric oxide synthesis in
murine peritoneal macrophages. Free Radic Biol Med 20:769
S. B. Christensen et al.
101. Mikkelsen EO, Thastrup O, Christensen SB (1988) Effects of thapsigargin in isolated rat
thoracic aorta. Pharmacol Toxicol 62:7
102. Mikkelsen EO, Poulsen SH, Christensen SB (1992) Comparison of the effects of thapsigargin and BAY K 8644 on spontaneous mechanical activity in rat portal vein and contractile
responses of rat cardiac muscle. Pharmacol Toxicol 70:152
103. Kijima Y, Ogunbunmi E, Fleischer S (1991) Drug action of thapsigargin on the Ca 2+ pump
protein of sarcoplasmic reticulum. J Biol Chem 266:22912
104. Lytton J, Westlin M, Hanley MR (1991) Thapsigargin inhibits the sarcoplasmic or endoplasmic
reticulum Ca-ATPase family of calcium pumps. J Biol Chem 266:17067
105. Patkar SA, Rasmussen U, Diamant B (1979) On the mechanism of histamine release induced
by thapsigargin from Thapsia garganica L. Agents Actions 9:53
106. Ali H, Christensen SB, Foreman JC, Pearce FL, Piotrowski W, Thastrup O (1985) The ability
of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. Br
J Pharmacol 85:705
107. Shiraishi M, Hirasawa N, Kobayashi Y, Oikawa S, Murakami A, Ohuchi K (2000) Participation
of mitogen-activated protein kinase in thapsigargin- and TPA-induced histamine production
in murine macrophage RAW 264.7 cells. Br J Pharmacol 129:515
108. Furuya Y, Lundmo P, Short AD, Gill DL, Isaacs JT (1994) The role of calcium, pH, and cell
proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer
cells induced by thapsigargin. Cancer Res 54:6167
109. Lee WJ, Monteith GR, Roberts-Thomson J (2006) Calcium transport and signaling in the
mammary gland: targets for breast cancer. Biochim Biophys Acta Rev Cancer 1765:235
110. Monteith GR, McAndrew D, Faddy HM, Roberts-Thomson SJ (2007) Calcium and cancer:
targeting Ca 2+ transport. Nat Rev Cancer 7:519
111. Berna-Erro A, Jardin I, Salido GM, Rosado JA (2017) Role of STIM2 in cell function and
physiopathology. J Physiol 595:3111
112. Bong AHL, Monteith GR (2018) Calcium signaling and the therapeutic targeting of cancer
cells. Biochim Biophys Acta Mol Cell Res 1865B:1786
113. Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium
signalling. Nat Rev Mol Cell Biol 1:11
114. Stutzmann GE, Mattson MP (2011) Endoplasmic reticulum Ca 2+ handling in excitable cells
in health and disease. Pharmacol Rev 63:700
115. Wuytack F, Raeymaekers L, Missiaen L (2002) Molecular physiology of the SERCA and
SPCA pumps. Cell Calcium 32:279
116. Brini M, Carafoli E (2009) Calcium pumps in health and disease. Physiol Rev 89:1341
117. Palmgren MG, Nissen P (2011) P-type ATPases. Ann Rev Biophys 40:243
118. Mochly-Rosen D, Das K, Grimes KV (2012) Protein kinase C, an elusive therapeutic target?
Nat Rev Drug Discov 11:937
119. Krishna S, Zhong X-P (2013) Regulation of lipid signaling by diacylglycerol kinases during
T cell development and function. Front Immunol 2013:178
120. Smyth JT, DeHaven WI, Jones BF, Mercer JC, Trebak M, Vazquez G, Putney JW (2006)
Emerging perspectives in store-operated Ca 2+ entry: roles of Orai, Stim and TRP. Biochim
Biophys Acta Mol Cell Res 1763:1147
121. Ambudkar IS, de Souza LB, Ong HL (2017) TRPC1, Orai1, and STIM1 in SOCE: friends in
tight spaces. Cell Calcium 63:33
122. Chemaly ER, Troncone L, Lebeche D (2018) SERCA control of cell death and survival. Cell
Calcium 69:46
123. Yatime L, Buch-Pedersen MJ, Musgaard M, Morth JP, Lund Winther A-M, Pedersen BP,
Olesen C, Andersen JP, Vilsen B, Schioett B, Palmgren MG, Moeller JV, Nissen P, Fedosova
N (2009) P-type ATPases as drug targets: tools for medicine and science. Biochim Biophys
Acta Bioenerg 1787:207
124. Jun CD, Yoon HJ, Park YC, Lee SY, Kang SS, Kim HM, Chung HT (1996) Synergistic
cooperation between thapsigargin and phorbol ester for induction of nitric oxide synthesis in
murine peritoneal macrophages. Free Radic Biol Med 20:769