INDEX
A
Additive manufacturing (AM)..................................32, 75
hydrogel-based materials ........................................ 137
melt extrusion (see Melt extrusion of thermoplastics)
and polymer processing approaches....................... 101
Alcohol/methylaluminum diphenolate system (AlMe
(OR) 2 ) ............................................................ 56
Alginate............................................................... 46–48, 50
Alginate hydrogel
alginate solution ...................................................... 147
biocompatibility ...................................................... 144
biofabrication .......................................................... 147
bioprinting............................................................... 146
and cross-linking reagents ............................. 144, 145
design and 3D printing........................................... 145
Angiogenic growth factors ........................................... 163
B
Biodegradable polyester................................................ 103
Biodegradable polymeric material.................................. 22
Bioextrusion ....................77, 79, 81, 82, 87, 90, 96, 143
Biofabrication .................................................64, 125, 147
Bioink..................................................... 52, 137–139, 141
Biomedical scaffolds...................................................... 101
Biomimetic boundary-based scaffold design
engineering optimization schemes......................... 4–6
internal fixed core structure ..................................... 14
μCT data (see Micro-CT data (μCT data))
scaffolds ....................................................................... 4
solicitation environment ........................................... 11
STL model...........................................................6, 8, 9
tensile stress ................................................................. 9
tissue engineering.......................................3, 4, 15, 17
topological optimization ........................... 5–6, 13, 16
topological scaffold model .................................11, 15
Bioprinted chondrocyte constructs.............................. 176
C
Cell-laden clay-based bioinks ...................................68, 69
Cell-laden scaffolds ............................................ 66, 69, 71
Chondroitin sulfate 2-aminoethyl methacrylate
(CS-AEMA) ...................................... 47–49, 52
Chondrotoxicity ............................................................ 176
Coaxial bioprinting
photocurable biopolymers (see Photocurable
biopolymers)
Coaxial nozzle ............................................................... 182
Complex microarchitectures......................................... 164
Computed tomography (CT) ........................................ 24
Computer-aided design (CAD) ...............................24, 26
AutoCAD
® software ...................................... 151, 153
MedCAD ................................................................. 159
personalized implants.............................................. 149
scaffold design ......................................................... 153
3D bioprinting paradigm ....................................... 150
and traditional 3D printing .................................... 150
tubular constructs without medical imaging......... 153
Computer-aided wet-spinning (CAWS)
computer-controlled deposition ............................ 102
experimental steps ................................................... 103
fabrication, polyester-based scaffolds ..................... 105
as hybrid AM technique ......................................... 101
innovative CAWS approach .................................... 103
materials
fabrication setup ................................................ 103
reagents.............................................................. 103
optimized parameters.............................................. 103
polymeric mixtures preparation.............................. 106
polymer-lean phase.................................................. 102
post-fabrication treatment ...................................... 107
scaffold fabrication ......................................... 106, 107
Controlling process parameters
AM (see Additive manufacturing (AM))
extrusion rate............................................................. 36
film ............................................................................. 37
functional graded structures..................................... 34
fused deposition modelling ...................................... 32
G-code (see G-code)
geometry and mechanical characterization........35, 37
stress shielding........................................................... 32
3D printing................................................................ 38
Conventional electrospinning technique..................... 125
D
Differential scanning calorimetry (DSC).................78–80
Digital light processing (DLP)....................................... 25
Dimethylmethylene blue (DMMB) ............................. 179
Alberto Rainer and Lorenzo Moroni (eds.), Computer-Aided Tissue Engineering: Methods and Protocols,
Methods in Molecular Biology, vol. 2147, https://doi.org/10.1007/978-1-0716-0611-7,
© Springer Science+Business Media, LLC, part of Springer Nature 2021
185
A
Additive manufacturing (AM)..................................32, 75
hydrogel-based materials ........................................ 137
melt extrusion (see Melt extrusion of thermoplastics)
and polymer processing approaches....................... 101
Alcohol/methylaluminum diphenolate system (AlMe
(OR) 2 ) ............................................................ 56
Alginate............................................................... 46–48, 50
Alginate hydrogel
alginate solution ...................................................... 147
biocompatibility ...................................................... 144
biofabrication .......................................................... 147
bioprinting............................................................... 146
and cross-linking reagents ............................. 144, 145
design and 3D printing........................................... 145
Angiogenic growth factors ........................................... 163
B
Biodegradable polyester................................................ 103
Biodegradable polymeric material.................................. 22
Bioextrusion ....................77, 79, 81, 82, 87, 90, 96, 143
Biofabrication .................................................64, 125, 147
Bioink..................................................... 52, 137–139, 141
Biomedical scaffolds...................................................... 101
Biomimetic boundary-based scaffold design
engineering optimization schemes......................... 4–6
internal fixed core structure ..................................... 14
μCT data (see Micro-CT data (μCT data))
scaffolds ....................................................................... 4
solicitation environment ........................................... 11
STL model...........................................................6, 8, 9
tensile stress ................................................................. 9
tissue engineering.......................................3, 4, 15, 17
topological optimization ........................... 5–6, 13, 16
topological scaffold model .................................11, 15
Bioprinted chondrocyte constructs.............................. 176
C
Cell-laden clay-based bioinks ...................................68, 69
Cell-laden scaffolds ............................................ 66, 69, 71
Chondroitin sulfate 2-aminoethyl methacrylate
(CS-AEMA) ...................................... 47–49, 52
Chondrotoxicity ............................................................ 176
Coaxial bioprinting
photocurable biopolymers (see Photocurable
biopolymers)
Coaxial nozzle ............................................................... 182
Complex microarchitectures......................................... 164
Computed tomography (CT) ........................................ 24
Computer-aided design (CAD) ...............................24, 26
AutoCAD
® software ...................................... 151, 153
MedCAD ................................................................. 159
personalized implants.............................................. 149
scaffold design ......................................................... 153
3D bioprinting paradigm ....................................... 150
and traditional 3D printing .................................... 150
tubular constructs without medical imaging......... 153
Computer-aided wet-spinning (CAWS)
computer-controlled deposition ............................ 102
experimental steps ................................................... 103
fabrication, polyester-based scaffolds ..................... 105
as hybrid AM technique ......................................... 101
innovative CAWS approach .................................... 103
materials
fabrication setup ................................................ 103
reagents.............................................................. 103
optimized parameters.............................................. 103
polymeric mixtures preparation.............................. 106
polymer-lean phase.................................................. 102
post-fabrication treatment ...................................... 107
scaffold fabrication ......................................... 106, 107
Controlling process parameters
AM (see Additive manufacturing (AM))
extrusion rate............................................................. 36
film ............................................................................. 37
functional graded structures..................................... 34
fused deposition modelling ...................................... 32
G-code (see G-code)
geometry and mechanical characterization........35, 37
stress shielding........................................................... 32
3D printing................................................................ 38
Conventional electrospinning technique..................... 125
D
Differential scanning calorimetry (DSC).................78–80
Digital light processing (DLP)....................................... 25
Dimethylmethylene blue (DMMB) ............................. 179
Alberto Rainer and Lorenzo Moroni (eds.), Computer-Aided Tissue Engineering: Methods and Protocols,
Methods in Molecular Biology, vol. 2147, https://doi.org/10.1007/978-1-0716-0611-7,
© Springer Science+Business Media, LLC, part of Springer Nature 2021
185