38
Ie. V. Pylypchuk et al.
Fig. 2.2 Isotherms of
adsorption of human normal
Ig on the surface of
Fe 3 O 4 /H£ and
Fe 3 O 4 /H£/Ag
nanocomposites from
phosphate buffer
0.00 0.05 0.10 0.15 0.20 0.25
0
5
10
15
20
25
30
Fe 3 O 4 /HА
Fe 3 O 4 /HА/Ag
А, mg/g
C eq. , mg/ml
Fig. 2.3 Isotherms of
adsorption of human normal
Ig on the surface of
Fe 3 O 4 /H£ and
Fe 3 O 4 /H£/Ag
nanocomposites from saline
solution
0.0
0.2
0.4
0.6
0.8
0
10
20
30
40
Fe 3 O 4 /HA
Fe 3 O 4 /HA/Ag
А, mg/ml
С eq. , mg/ml
Table 2.1 Effect of magnetosensitive NCs with adsorbed CP conjugated with monoclonal
antibodies on the survivability of ¯´F-7 line cells
Dead cells, %
Comparison
control
Action of
control samples
Fe 3 ± 4 /H£ + CP
Fe 3 ± 4 /H£
+ CD 95
Fe 3 ± 4 /H£ +
CP + CD 95
Cisplatin (CP)
´ = 2.5 μg/ml
25
48
Antibody CD
95
´ = 0.2 μg/ml
10
27
show that the use of nanocomposites with antibodies in principle allows to realize
the recognition of specific cells.
Adsorption of Doxorubicin by Magnetite/Hydroxyapatite Nanocomposites
The adsorption of doxorubicin by magnetite/hydroxyapatite nanocomposites is
studied in [2].
Doxorubicin [26] is an antitumor antibiotic of anthracyclines range; the empirical
formula is C 27 H 29 NO 11 . It is characterized by antimitotic and antiproliferative
effects. The mechanism of antineoplastic activity is in an interaction with DNA,
a formation of free radicals and a direct impact on cell membranes along with an
inhibition of the synthesis of nucleic acids.