Chapter 2
Multifunctional Magnetic
Nanocomposites on the Base of Magnetite
and Hydroxyapatite for Oncology
Applications
Ie. V. Pylypchuk, M. V. Abramov, A. L. Petranovska, S. P. Turanksa,
T. M. Budnyak, N. V. Kusyak, and P. P. Gorbyk
In works [11–13, 16, 20, 36–38], the concept of a chemical design of magnetosensitive nanocomposites with a multilevel hierarchical nano-architecture was
substantiated which are characterized by the functions of “nano-clinics” [12] and
medico-biological nanorobots [10–13, 16, 36, 37]: recognition of microbiological
objects in biological media; targeted drug delivery into target cells and organs
and deposition; complex local chemo-, immuno-, neutron capture, hyperthermic,
photodynamic therapy and real-time magnetic resonance imaging diagnostics,
detoxification of the body by adsorption of residual cell debris, virus particles, heavy
metal ions, etc. and their removal by the means of a magnetic field.
In terms of synthesis of the abovementioned magnetosensitive nanocomposites
(NCs), the researchers have a significant interest in nanostructures of the coreshell type on the basis of single-domain magnetite (Fe 3 O 4 ) and hydroxyapatite
(HA) that retain oncologic drugs of different functional purposes and different
mechanisms of action. Such NCs are characterized by the unique combination of
physical, chemical, and biological properties, by the possibility of production of
ferrofluids (FFs) on their basis [2, 3, 6, 7, 9, 17, 18, 22, 24, 34, 41]. Widespread
application as oncologic drugs has, in particular, the cytostatic drug cisplatin (CP),
the anthracycline antibiotic doxorubicin (DR) that are used practically in all the
schemes of modern chemotherapy as well as antibodies that allow realizing the
principles of recognition of antigens and immunotherapy.
Ie. V. Pylypchuk · M. V. Abramov · A. L. Petranovska · S. P. Turanksa · T. M. Budnyak ()
P. P. Gorbyk
Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Kyiv,
Ukraine
N. V. Kusyak
Ivan Franko Zhytomyr State University, Zhytomyr, Ukraine
© Springer International Publishing AG, part of Springer Nature 2018
O. Fesenko, L. Yatsenko (eds.), Nanochemistry, Biotechnology, Nanomaterials,
and Their Applications, Springer Proceedings in Physics 214,
https://doi.org/10.1007/978-3-319-92567-7_2
35
Multifunctional Magnetic
Nanocomposites on the Base of Magnetite
and Hydroxyapatite for Oncology
Applications
Ie. V. Pylypchuk, M. V. Abramov, A. L. Petranovska, S. P. Turanksa,
T. M. Budnyak, N. V. Kusyak, and P. P. Gorbyk
In works [11–13, 16, 20, 36–38], the concept of a chemical design of magnetosensitive nanocomposites with a multilevel hierarchical nano-architecture was
substantiated which are characterized by the functions of “nano-clinics” [12] and
medico-biological nanorobots [10–13, 16, 36, 37]: recognition of microbiological
objects in biological media; targeted drug delivery into target cells and organs
and deposition; complex local chemo-, immuno-, neutron capture, hyperthermic,
photodynamic therapy and real-time magnetic resonance imaging diagnostics,
detoxification of the body by adsorption of residual cell debris, virus particles, heavy
metal ions, etc. and their removal by the means of a magnetic field.
In terms of synthesis of the abovementioned magnetosensitive nanocomposites
(NCs), the researchers have a significant interest in nanostructures of the coreshell type on the basis of single-domain magnetite (Fe 3 O 4 ) and hydroxyapatite
(HA) that retain oncologic drugs of different functional purposes and different
mechanisms of action. Such NCs are characterized by the unique combination of
physical, chemical, and biological properties, by the possibility of production of
ferrofluids (FFs) on their basis [2, 3, 6, 7, 9, 17, 18, 22, 24, 34, 41]. Widespread
application as oncologic drugs has, in particular, the cytostatic drug cisplatin (CP),
the anthracycline antibiotic doxorubicin (DR) that are used practically in all the
schemes of modern chemotherapy as well as antibodies that allow realizing the
principles of recognition of antigens and immunotherapy.
Ie. V. Pylypchuk · M. V. Abramov · A. L. Petranovska · S. P. Turanksa · T. M. Budnyak ()
P. P. Gorbyk
Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Kyiv,
Ukraine
N. V. Kusyak
Ivan Franko Zhytomyr State University, Zhytomyr, Ukraine
© Springer International Publishing AG, part of Springer Nature 2018
O. Fesenko, L. Yatsenko (eds.), Nanochemistry, Biotechnology, Nanomaterials,
and Their Applications, Springer Proceedings in Physics 214,
https://doi.org/10.1007/978-3-319-92567-7_2
35