Chapter 20
Magnetic Memory of Antitumor
Magneto-sensitive Nanocomplex
V. Orel, A. Shevchenko, O. Rykhalskyi, A. Romanov, A. Burlaka, and S. Lukin
20.1 Introduction
Drug delivery and release are important to improve the therapeutic effects of drugs
and reduce toxic side effects during cancer chemotherapy [1]. Drug release and
delivery into tumor can be improved using nanotechnology based on the utilization
of the antitumor magneto-sensitive nanocomplex (AMNC) with magnetic memory
effect. The magnetic memory effect is the ability of magnetic material (e.g., AMNC)
to remember the magnetic field strength at which its shape was mechanically
deformed [2].
Iron oxide nanoparticles (NPs) with spinel structure such as magnetite (Fe 3 O 4 )
are often used in antitumor treatment as AMNC placed in biocompatible magnetic
fluids since they have a low toxicity and peculiar magnetic properties [3]. In recent
years, a hybrid method of combined ultrahigh-field magnetic resonance imaging
(MRI) with controlled and localized radio-frequency heating in the tumor has been
V. Orel () · O. Rykhalskyi
National Cancer Institute, Kyiv, Ukraine
National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv,
Ukraine
A. Shevchenko
G.V. Kurdyumov Institute for Metal Physics of the National Academy of Sciences of Ukraine,
Kyiv, Ukraine
A. Romanov
National Cancer Institute, Kyiv, Ukraine
A. Burlaka · S. Lukin
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National
Academy of Sciences of Ukraine, Kyiv, Ukraine
© Springer International Publishing AG, part of Springer Nature 2018
O. Fesenko, L. Yatsenko (eds.), Nanochemistry, Biotechnology, Nanomaterials,
and Their Applications, Springer Proceedings in Physics 214,
https://doi.org/10.1007/978-3-319-92567-7_20
323
Magnetic Memory of Antitumor
Magneto-sensitive Nanocomplex
V. Orel, A. Shevchenko, O. Rykhalskyi, A. Romanov, A. Burlaka, and S. Lukin
20.1 Introduction
Drug delivery and release are important to improve the therapeutic effects of drugs
and reduce toxic side effects during cancer chemotherapy [1]. Drug release and
delivery into tumor can be improved using nanotechnology based on the utilization
of the antitumor magneto-sensitive nanocomplex (AMNC) with magnetic memory
effect. The magnetic memory effect is the ability of magnetic material (e.g., AMNC)
to remember the magnetic field strength at which its shape was mechanically
deformed [2].
Iron oxide nanoparticles (NPs) with spinel structure such as magnetite (Fe 3 O 4 )
are often used in antitumor treatment as AMNC placed in biocompatible magnetic
fluids since they have a low toxicity and peculiar magnetic properties [3]. In recent
years, a hybrid method of combined ultrahigh-field magnetic resonance imaging
(MRI) with controlled and localized radio-frequency heating in the tumor has been
V. Orel () · O. Rykhalskyi
National Cancer Institute, Kyiv, Ukraine
National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv,
Ukraine
A. Shevchenko
G.V. Kurdyumov Institute for Metal Physics of the National Academy of Sciences of Ukraine,
Kyiv, Ukraine
A. Romanov
National Cancer Institute, Kyiv, Ukraine
A. Burlaka · S. Lukin
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National
Academy of Sciences of Ukraine, Kyiv, Ukraine
© Springer International Publishing AG, part of Springer Nature 2018
O. Fesenko, L. Yatsenko (eds.), Nanochemistry, Biotechnology, Nanomaterials,
and Their Applications, Springer Proceedings in Physics 214,
https://doi.org/10.1007/978-3-319-92567-7_20
323