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R. Kozakevych et al.
active compound release is complicated less by swelling of matrices. However, for
polymeric composites, understanding for desorption process better described by the
Korsmeyer-Peppas model pointed on decisive role of gel fraction of polymer in
active substrate desorption.
9.3.6 Bactericidal Activity of Polymeric Films
The main parameter for polymeric carriers of biological active matter is stability
toward bacteria pollution. In order to prevent bacteria action, usually medical
composite includes appropriate organic or inorganic compounds. As supposed
the polymeric carriers based on chitosan will have resistance against bacteria
growth. The study was performed using Pseudomonas aeruginosa. It was found that
the more effective bactericide is Gel/HEMA composite material. The composites
Gel/Chit and Gel/Chit/HEMA had worse results but also show a good bactericidal
activity (Fig. 9.7). All other polymeric materials are inactive toward Pseudomonas
aeruginosa. It should be noted that carbon nanotube presence reduces the bactericidal properties of the material.
9.4 Conclusions
Systems based on silica and polymer matrices that can be used as carriers for
biological antioxidant, namely, natural tannin, were synthesized. The release rate
of Enoxil from the fumed silica A-300 that was much higher compared with the
release rate from the composites prepared by sol-gel method was found. The control
of the Enoxil release was achieved using a silica matrix containing phenyl groups
in the surface layer, which makes it possible to consider the developed material as a
promising carrier for biologically active substances.
Among the studied polymeric compositions synthesized polymeric materials the
films containing HEMA has the most rigid structure. Polymeric films based on
gelatin and chitosan were found to show the highest swelling degree and reduced
release. A composite based on gelatin and chitosan is promising, but the best carriers
in this line of samples were Gel/HEMA/VA. According to the results of testing
the synthesized polymer films, the bactericidal activity was found for Gel/HEMA,
Gel/Chit/HEMA, and Gel/Chit composites. The obtained result of biological test
demonstrated that introducing nanotubes into polymeric materials reduced their
bacteriostatic stability. The composites elaborated can be utilized as Enoxil carriers
for oral and transdermal applications.
R. Kozakevych et al.
active compound release is complicated less by swelling of matrices. However, for
polymeric composites, understanding for desorption process better described by the
Korsmeyer-Peppas model pointed on decisive role of gel fraction of polymer in
active substrate desorption.
9.3.6 Bactericidal Activity of Polymeric Films
The main parameter for polymeric carriers of biological active matter is stability
toward bacteria pollution. In order to prevent bacteria action, usually medical
composite includes appropriate organic or inorganic compounds. As supposed
the polymeric carriers based on chitosan will have resistance against bacteria
growth. The study was performed using Pseudomonas aeruginosa. It was found that
the more effective bactericide is Gel/HEMA composite material. The composites
Gel/Chit and Gel/Chit/HEMA had worse results but also show a good bactericidal
activity (Fig. 9.7). All other polymeric materials are inactive toward Pseudomonas
aeruginosa. It should be noted that carbon nanotube presence reduces the bactericidal properties of the material.
9.4 Conclusions
Systems based on silica and polymer matrices that can be used as carriers for
biological antioxidant, namely, natural tannin, were synthesized. The release rate
of Enoxil from the fumed silica A-300 that was much higher compared with the
release rate from the composites prepared by sol-gel method was found. The control
of the Enoxil release was achieved using a silica matrix containing phenyl groups
in the surface layer, which makes it possible to consider the developed material as a
promising carrier for biologically active substances.
Among the studied polymeric compositions synthesized polymeric materials the
films containing HEMA has the most rigid structure. Polymeric films based on
gelatin and chitosan were found to show the highest swelling degree and reduced
release. A composite based on gelatin and chitosan is promising, but the best carriers
in this line of samples were Gel/HEMA/VA. According to the results of testing
the synthesized polymer films, the bactericidal activity was found for Gel/HEMA,
Gel/Chit/HEMA, and Gel/Chit composites. The obtained result of biological test
demonstrated that introducing nanotubes into polymeric materials reduced their
bacteriostatic stability. The composites elaborated can be utilized as Enoxil carriers
for oral and transdermal applications.