150
R. Kozakevych et al.
serious and even irreversible tissue damage due to the destruction of collagen and
the peroxidation of cell membranes. Antibiotics are increasingly used to prevent and
treat bacterial infectious diseases. The stability of pathogenic bacteria is developed
when their application is excessive and uncontrolled. In the future of increasing
antibiotic resistance, the development of new strategies to fight bacteria will be
welcome [8].
Antimicrobial and antiviral properties of plant polyphenols were found in
extracts isolated from various plant objects. The decoction of Cocos nucifera L.
husk fibers has been used in northeastern Brazil traditional medicine for treatment
of diarrhea and arthritis. Water extract obtained from coconut husk fiber revealed
antimicrobial activity against Staphylococcus aureus. One of the fractions rich in
catechin also showed inhibitory activity against acyclovir-resistant herpes simplex
virus [9]. The native tannin also can be used as biologically active materials with
antioxidant and bacteriostatic properties. Oxidized tannins are utilized as effective
biologically active matters in nutritional supplements [10]. The wide distribution of
polyphenol compounds in plants, low toxicity, and high pharmacological activity
may be promising for the development of a number of drugs based on them.
The article [11] presents data about the antimicrobial activity of the
autochthonous compound of tannin source Enoxil. Enoxil preparation was obtained
from wine waste following oxidation of enotannins with hydrogen peroxide. It was
established that the Enoxil compounds suppress activity of Pseudomonas bacteria.
The search for carriers will be promising for this purpose. Further improvement
of the preparations of Enoxil group may be performed by immobilizing such natural
antioxidant on the surface of nonporous nanosilica, allowed for use as food additives
and fillers [12, 13].
Among the polymeric carriers, gelatin stands out strongly due to several key
advantages, namely, this natural polymer is highly biocompatible and biodegradable
in a physiological environment. In addition, release kinetics from gelatin depends
on carrier degradation, which can be tuned by varying gelatin molecular weight,
the extent of material cross-linking, or synergistic use of gelatin with several
other polymeric materials. Gelatin and chitosan form polyionic complexes, and
therefore composite construction, drug release kinetics, and degradation can be
modified. In work [14] gelatin/chitosan sponges have been investigated for use
as release vehicles for wound treatment. In addition to sponges, gelatin/chitosan
microparticles have been successfully designed, with sustained delivery of basic
fibroblast growth factor for over 2 weeks in vitro. In study [15] it was reported on
simultaneous copolymerization of 2-hydroxyethyl methacrylate with gelatin using
blending and casting method, where simultaneous evaporation at room temperature
was the driving force.
The aim of this work was to prepare the silica-Enoxil nanobiocomposites and
Enoxil-polymer films to study the active substance release rate.
R. Kozakevych et al.
serious and even irreversible tissue damage due to the destruction of collagen and
the peroxidation of cell membranes. Antibiotics are increasingly used to prevent and
treat bacterial infectious diseases. The stability of pathogenic bacteria is developed
when their application is excessive and uncontrolled. In the future of increasing
antibiotic resistance, the development of new strategies to fight bacteria will be
welcome [8].
Antimicrobial and antiviral properties of plant polyphenols were found in
extracts isolated from various plant objects. The decoction of Cocos nucifera L.
husk fibers has been used in northeastern Brazil traditional medicine for treatment
of diarrhea and arthritis. Water extract obtained from coconut husk fiber revealed
antimicrobial activity against Staphylococcus aureus. One of the fractions rich in
catechin also showed inhibitory activity against acyclovir-resistant herpes simplex
virus [9]. The native tannin also can be used as biologically active materials with
antioxidant and bacteriostatic properties. Oxidized tannins are utilized as effective
biologically active matters in nutritional supplements [10]. The wide distribution of
polyphenol compounds in plants, low toxicity, and high pharmacological activity
may be promising for the development of a number of drugs based on them.
The article [11] presents data about the antimicrobial activity of the
autochthonous compound of tannin source Enoxil. Enoxil preparation was obtained
from wine waste following oxidation of enotannins with hydrogen peroxide. It was
established that the Enoxil compounds suppress activity of Pseudomonas bacteria.
The search for carriers will be promising for this purpose. Further improvement
of the preparations of Enoxil group may be performed by immobilizing such natural
antioxidant on the surface of nonporous nanosilica, allowed for use as food additives
and fillers [12, 13].
Among the polymeric carriers, gelatin stands out strongly due to several key
advantages, namely, this natural polymer is highly biocompatible and biodegradable
in a physiological environment. In addition, release kinetics from gelatin depends
on carrier degradation, which can be tuned by varying gelatin molecular weight,
the extent of material cross-linking, or synergistic use of gelatin with several
other polymeric materials. Gelatin and chitosan form polyionic complexes, and
therefore composite construction, drug release kinetics, and degradation can be
modified. In work [14] gelatin/chitosan sponges have been investigated for use
as release vehicles for wound treatment. In addition to sponges, gelatin/chitosan
microparticles have been successfully designed, with sustained delivery of basic
fibroblast growth factor for over 2 weeks in vitro. In study [15] it was reported on
simultaneous copolymerization of 2-hydroxyethyl methacrylate with gelatin using
blending and casting method, where simultaneous evaporation at room temperature
was the driving force.
The aim of this work was to prepare the silica-Enoxil nanobiocomposites and
Enoxil-polymer films to study the active substance release rate.