Contents
1 Reactive Platforms for Controllable Fabrication of Functional
(Bio)Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
1.1 Scope of Surface Modification for (Bio)Reactive Platforms
and Functional (Bio)Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
1.2 Chemical and Topographical Pattern Fabrication
from Micrometer to Nanometer Length Scales . . . . . . . . . . . . . . . . . .
2
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4
2 Surface Reactions and Fabrication of Bioreactive Platforms
Based on Organic and Polymeric Films: From Micrometer
to Nanometer Length Scale . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
7
2.1 Introduction: Bioreactive Platforms and Biointerfaces
via Organic and Polymeric Films . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
7
2.1.1 Organic and Polymeric Films . . . . . . . . . . . . . . . . . . . . . . . . . .
9
2.1.2 Pattern Fabrication on Organic and Polymeric Films . . . . . . 10
2.2 Surface Reactions of Organic and Polymeric Films . . . . . . . . . . . . . . 12
2.2.1 Self-assembled Monolayers . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
2.2.2 Surface Modification with Polymers . . . . . . . . . . . . . . . . . . . . 21
2.3 Patterned Organic and Polymeric Films for Tailored
(Bio)Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
2.3.1 Microcontact Printing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
2.3.2 Selective Molecular Assembly Patterning (SMAP) . . . . . . . . 33
2.3.3 Embossing and Nano-Imprinting . . . . . . . . . . . . . . . . . . . . . . . 34
2.3.4 Self-assembled Block Copolymer Patterns . . . . . . . . . . . . . . . 36
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42
3 Confinement Effects on the Reactivity in Ultrathin Polymer
Films: Kinetics and Temperature Dependence of the Hydrolysis
of NHS and TBA Esters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
3.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
3.2 Ultrathin PNHSMA Polymer Films . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
3.2.1 Characterization of the Hydrolysis of PNHSMA Films . . . . 47
3.2.2 Temperature Dependence of Reaction Kinetics . . . . . . . . . . . 51
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