416
monoxide as the terminal reductant leading to the benzopyrrolidine heterocycles
(Scheme 60) [116].
C–P bond formation: A copper-catalyzed protocol was also established to enable
the α-phosphorylation of glycine derivatives under mild reaction condition (Scheme
61) [117]. Substituent attached with the amine part of glycine plays a crucial role in
this α-phosphorylation reaction by lowering the oxidation potential of the substrate
and stabilizing the intermediates involved. It was proposed that in the presence of
the Cu catalyst and tert-butyl hydroperoxide (TBHP), the glycine derivative forms
an imino amide intermediate that can be further stabilized by the copper catalyst
Scheme 59 Synthesis of hydantoin derivatives via copper-catalyzed α-amination
Scheme 60 Palladium-catalyzed intramolecular amination of nitroarenes
Scheme 61 Copper-catalyzed α-phosphorylation of glycine derivatives
A. Gupta et al.
monoxide as the terminal reductant leading to the benzopyrrolidine heterocycles
(Scheme 60) [116].
C–P bond formation: A copper-catalyzed protocol was also established to enable
the α-phosphorylation of glycine derivatives under mild reaction condition (Scheme
61) [117]. Substituent attached with the amine part of glycine plays a crucial role in
this α-phosphorylation reaction by lowering the oxidation potential of the substrate
and stabilizing the intermediates involved. It was proposed that in the presence of
the Cu catalyst and tert-butyl hydroperoxide (TBHP), the glycine derivative forms
an imino amide intermediate that can be further stabilized by the copper catalyst
Scheme 59 Synthesis of hydantoin derivatives via copper-catalyzed α-amination
Scheme 60 Palladium-catalyzed intramolecular amination of nitroarenes
Scheme 61 Copper-catalyzed α-phosphorylation of glycine derivatives
A. Gupta et al.