1.5 The Topic Selection Ideas and Research Focus of This Thesis
17
Fig. 1.10 Workflows for deploying stapled peptides for biological applications. Reprints with
permission from ref. 34
the sole structure factor affects the peptides’ biological activities. A proper platform
that can generate peptide isomers with identical chemical composition but different
chemical structures are expected to provide a solution for tackling the dilemma and
answer the question of how does the helical conformation influences the peptide
activity, such as binding affinity, cell permeability, and in vivo stability.
In the first chapter, the diversity and heterogeneity of protein-protein interactions
are introduced. To design effective stapled peptide inhibitors for different targets,
there are higher requirements for synthetic methods that can access abundant linker
17
Fig. 1.10 Workflows for deploying stapled peptides for biological applications. Reprints with
permission from ref. 34
the sole structure factor affects the peptides’ biological activities. A proper platform
that can generate peptide isomers with identical chemical composition but different
chemical structures are expected to provide a solution for tackling the dilemma and
answer the question of how does the helical conformation influences the peptide
activity, such as binding affinity, cell permeability, and in vivo stability.
In the first chapter, the diversity and heterogeneity of protein-protein interactions
are introduced. To design effective stapled peptide inhibitors for different targets,
there are higher requirements for synthetic methods that can access abundant linker