87
embryonic stem cells using mesoporous nanoparticles. Nanomedicine (Lond) 9(16):2457–2466.
https://doi.org/10.2217/nnm.14.23
Genschow E, Spielmann H, Scholz G, Pohl I, Seiler A, Clemann N, Bremer S, Becker K (2004)
Validation of the embryonic stem cell test in the international European Centre for the
Validation of alternative methods validation study on three in vitro embryotoxicity tests. Altern
Lab Anim 32(3):209–244. https://doi.org/10.1177/026119290403200305
Gomes Lucas C, Härter Remião M, Rossi Komninou E, Borges Domingues W, Haas C, Marques
Moura de Leon P, Farias Campos V, Ourique A, Guterres SS, Pohlmann AR, Basso AC,
Kömmling Seixas F, Ruver Beck RC, Collares T (2015) Tretinoin-loaded lipid- core nanocapsules decrease reactive oxygenspecies levels and improve bovine embryonic development duringin vitro oocyte maturation. Reprod Toxicol 58:131–139. https://doi.org/10.1016/j.
reprotox.2015.10.004
Grafmueller S, Manser P, Krug HF, Wick P, von Mandach U (2013) Determination of the transport
rate of Xenobiotics and nanomaterials across the placenta using the ex vivo human placental
perfusion model. J Vis Exp 76:e50401. https://doi.org/10.3791/50401
Grafmueller S, Manser P, Diener L, Diener PA, Maeder-Althaus X, Maurizi L, Jochum W, Krug
HF, Buerki-Thurnherr T, von Mandach U, Wick P (2015a) Bidirectional transfer study of
polystyrene nanoparticles across the placental barrier in an ex vivo human placental perfusion
model. Environ Health Perspect 123:1280–1286. https://doi.org/10.1289/ehp.1409271
Grafmueller S, Manser P, Diener L, Maurizi L, Diener PA, Hofmann H, Jochum W, Krug HF,
Buerki-Thurnherr T, von Mandach U, Wick P (2015b) Transfer studies of polystyrene nanoparticles in the ex vivo human placenta perfusion model: key sources of artifacts. Sci Technol Adv
Mater 16(4):044602. https://doi.org/10.1088/1468- 6996/16/4/044602
Grande D, Ramier J, Versace DL, Renard E, Langlois V (2017) Design of functionalized biodegradable PHA-based electrospun scaffolds meant for tissue engineering applications. New
Biotechnol 37(Pt A):129–137. https://doi.org/10.1016/j.nbt.2016.05.0
Hackelberg S, Tuck SJ, He L, Rastogi A, White C, Liu L, Prieskorn DM, Miller RJ, Chan C,
Loomis BR, Corey JM, Miller JM, Duncan RK (2017) Nanofibrous scaffolds for the guidance of stem cell-derived neurons for auditory nerve regeneration. PLoS One 12(7):e0180427.
https://doi.org/10.1371/journal.pone.0180427
Hamm JT, Ceger P, Allen D, Stout M, Maull EA, Baker G, Zmarowski A, Padilla S, Perkins
E, Planchart A, Stedman D, Tal T, Tanguay RL, Volz DC, Wilbanks MS, Walker NJ (2019)
Characterizing sources of variability in zebrafish embryo screening protocols. ALTEX
36(1):103–120. https://doi.org/10.14573/altex.1804162
Han JW, Jeong JK, Gurunathan S, Choi YJ, Das J, Kwon DN, Cho SG, Park C, Seo HG, Park
JK, Kim JH (2016a) Male- and female-derived somatic and germ cell-specific toxicity of
silver nanoparticles in mouse. Nanotoxicology 3:361–373. https://doi.org/10.3109/1743539
0.2015.1073396
Han Z, Yan Q, Ge W, Liu ZG, Gurunathan S, De Felici M, Shen W, Zhang XF (2016b) Cytotoxic
effects of ZnO nanoparticles on mouse testicular cells. Int J Nanomedicine 11:5187–5203.
https://doi.org/10.2147/IJN.S111447
Handral HK, Tong HJ, Islam I, Sriram G, Rosa V, Cao T (2016) Pluripotent stem cells: an
in vitro model for nanotoxicity assessments. J Appl Toxicol 36(10):1250–1258. https://doi.
org/10.1002/jat.3347
Hanot CC, Choi YS, Anani TB, Soundarrajan D, David AE (2015) Effects of Iron-oxide nanoparticle surface chemistry on uptake kinetics and cytotoxicity in Chinese hamster ovary cells-K1
cells. Int J Mol Sci 17:54–68. https://doi.org/10.3390/ijms17010054
Haque E, Ward AC (2018) Zebrafish as a model to evaluate nanoparticle toxicity. Nanomaterials
(Basel) 8(7) pii: E561. https://doi.org/10.3390/nano8070561
Hashemi E, Akhavan O, Shamsara M, Daliri M, Dashtizad M, Farmany A (2016) Synthesis and
cyto-genotoxicity evaluation of graphene on mice spermatogonial stem cells. Colloids Surf B
Biointerfaces 146:770–776. https://doi.org/10.1016/j.colsurfb.2016.07.019
3 Safety and Utility of Nanomaterials on Reproduction and Development: An Update…
embryonic stem cells using mesoporous nanoparticles. Nanomedicine (Lond) 9(16):2457–2466.
https://doi.org/10.2217/nnm.14.23
Genschow E, Spielmann H, Scholz G, Pohl I, Seiler A, Clemann N, Bremer S, Becker K (2004)
Validation of the embryonic stem cell test in the international European Centre for the
Validation of alternative methods validation study on three in vitro embryotoxicity tests. Altern
Lab Anim 32(3):209–244. https://doi.org/10.1177/026119290403200305
Gomes Lucas C, Härter Remião M, Rossi Komninou E, Borges Domingues W, Haas C, Marques
Moura de Leon P, Farias Campos V, Ourique A, Guterres SS, Pohlmann AR, Basso AC,
Kömmling Seixas F, Ruver Beck RC, Collares T (2015) Tretinoin-loaded lipid- core nanocapsules decrease reactive oxygenspecies levels and improve bovine embryonic development duringin vitro oocyte maturation. Reprod Toxicol 58:131–139. https://doi.org/10.1016/j.
reprotox.2015.10.004
Grafmueller S, Manser P, Krug HF, Wick P, von Mandach U (2013) Determination of the transport
rate of Xenobiotics and nanomaterials across the placenta using the ex vivo human placental
perfusion model. J Vis Exp 76:e50401. https://doi.org/10.3791/50401
Grafmueller S, Manser P, Diener L, Diener PA, Maeder-Althaus X, Maurizi L, Jochum W, Krug
HF, Buerki-Thurnherr T, von Mandach U, Wick P (2015a) Bidirectional transfer study of
polystyrene nanoparticles across the placental barrier in an ex vivo human placental perfusion
model. Environ Health Perspect 123:1280–1286. https://doi.org/10.1289/ehp.1409271
Grafmueller S, Manser P, Diener L, Maurizi L, Diener PA, Hofmann H, Jochum W, Krug HF,
Buerki-Thurnherr T, von Mandach U, Wick P (2015b) Transfer studies of polystyrene nanoparticles in the ex vivo human placenta perfusion model: key sources of artifacts. Sci Technol Adv
Mater 16(4):044602. https://doi.org/10.1088/1468- 6996/16/4/044602
Grande D, Ramier J, Versace DL, Renard E, Langlois V (2017) Design of functionalized biodegradable PHA-based electrospun scaffolds meant for tissue engineering applications. New
Biotechnol 37(Pt A):129–137. https://doi.org/10.1016/j.nbt.2016.05.0
Hackelberg S, Tuck SJ, He L, Rastogi A, White C, Liu L, Prieskorn DM, Miller RJ, Chan C,
Loomis BR, Corey JM, Miller JM, Duncan RK (2017) Nanofibrous scaffolds for the guidance of stem cell-derived neurons for auditory nerve regeneration. PLoS One 12(7):e0180427.
https://doi.org/10.1371/journal.pone.0180427
Hamm JT, Ceger P, Allen D, Stout M, Maull EA, Baker G, Zmarowski A, Padilla S, Perkins
E, Planchart A, Stedman D, Tal T, Tanguay RL, Volz DC, Wilbanks MS, Walker NJ (2019)
Characterizing sources of variability in zebrafish embryo screening protocols. ALTEX
36(1):103–120. https://doi.org/10.14573/altex.1804162
Han JW, Jeong JK, Gurunathan S, Choi YJ, Das J, Kwon DN, Cho SG, Park C, Seo HG, Park
JK, Kim JH (2016a) Male- and female-derived somatic and germ cell-specific toxicity of
silver nanoparticles in mouse. Nanotoxicology 3:361–373. https://doi.org/10.3109/1743539
0.2015.1073396
Han Z, Yan Q, Ge W, Liu ZG, Gurunathan S, De Felici M, Shen W, Zhang XF (2016b) Cytotoxic
effects of ZnO nanoparticles on mouse testicular cells. Int J Nanomedicine 11:5187–5203.
https://doi.org/10.2147/IJN.S111447
Handral HK, Tong HJ, Islam I, Sriram G, Rosa V, Cao T (2016) Pluripotent stem cells: an
in vitro model for nanotoxicity assessments. J Appl Toxicol 36(10):1250–1258. https://doi.
org/10.1002/jat.3347
Hanot CC, Choi YS, Anani TB, Soundarrajan D, David AE (2015) Effects of Iron-oxide nanoparticle surface chemistry on uptake kinetics and cytotoxicity in Chinese hamster ovary cells-K1
cells. Int J Mol Sci 17:54–68. https://doi.org/10.3390/ijms17010054
Haque E, Ward AC (2018) Zebrafish as a model to evaluate nanoparticle toxicity. Nanomaterials
(Basel) 8(7) pii: E561. https://doi.org/10.3390/nano8070561
Hashemi E, Akhavan O, Shamsara M, Daliri M, Dashtizad M, Farmany A (2016) Synthesis and
cyto-genotoxicity evaluation of graphene on mice spermatogonial stem cells. Colloids Surf B
Biointerfaces 146:770–776. https://doi.org/10.1016/j.colsurfb.2016.07.019
3 Safety and Utility of Nanomaterials on Reproduction and Development: An Update…