88
Hawkins SJ, Crompton LA, Sood A, Saunders M, Boyle NT, Buckley A, Minogue AM, McComish
SF, Jiménez-Moreno N, Cordero-Llana O, Stathakos P, Gilmore CE, Kelly S, Lane JD, Case
CP, Caldwell MA (2018) Nanoparticle-induced neural toxicity across placental barriers is
mediated by autophagy and dependent on astrocytes. Nat Nanotechnol 13:427–433. https://
doi.org/10.1038/s41565- 018- 0085- 3
He JH, Gao JM, Huang CJ, Li CQ (2014) Zebrafish models for assessing developmental and reproductive toxicity. Neurotoxicol Teratol 42:35–42. https://doi.org/10.1016/j.ntt.2014.01.006
Heinlaan M, Muna M, Knöbel M, Kistler D, Odzak N, Kühnel D, Müller J, Gupta GS, Kumar
A, Shanker R, Sigg L (2016) Natural water as the test medium for ag and CuO nanoparticle
hazard evaluation: an interlaboratory case study. Environ Pollut 216:689–699. https://doi.
org/10.1016/j.envpol.2016.06.033
Higashisaka K, Nagano K, Yoshioka Y, Tsutsumi Y (2017) Nano-safety research: examining the
associations among the biological effects of nanoparticles and their physicochemical properties
and kinetics. Biol Pharm Bull 40(3):243–248. https://doi.org/10.1248/bpb.b16- 00854
Hoelting L, Scheinhardt B, Bondarenko O, Schildknecht S, Kapitza M, Tanavde V, Tan B, Lee
QY, Mecking S, Leist M, Kadereit S (2013) A 3-dimensional human embryonic stem cell
(hESC)-derived model to detect developmental neurotoxicity of nanoparticles. Arch Toxicol
87(4):721–733. https://doi.org/10.1007/s00204- 012- 0984- 2
Hong F, Zhao X, Chen M, Zhou Y, Ze Y, Wang L, Wang Y, Ge Y, Zhang Q, Ye L (2016) TiO2
nanoparticles-induced apoptosis of primary cultured Sertoli cells of mice. J Biomed Mater Res
Part A 2016(104A):124–135. https://doi.org/10.1002/jbm.a.35548
Hsieh MS, Shiao NH, Chan WH (2009) Cytotoxic effects of CdSe quantum dots on maturation of
mouse oocytes, fertilization, and fetal development. Int J Mol Sci 10(5):2122–2135. https://doi.
org/10.3390/ijms10052122
Hu J, Xie C, Ma H, Yang B, Ma PX, Chen YE (2012) Construction of vascular tissues with macroporous nano-fibrous scaffolds and smooth muscle cells enriched from differentiated embryonic
stem cells. PLoS One 7(4):e35580. https://doi.org/10.1371/journal.pone.0035580
Huang JP, Hsieh PC, Chen CY, Wang TY, Chen PC, Liu CC, Chen CC, Chen CP (2015) Nanoparticles
can cross mouse placenta and induce trophoblast apoptosis. Placenta 36(12):1433–1441.
https://doi.org/10.1016/j.placenta.2015.10.007
Ilekis JV, Tsilou E, Fisher S, Abrahams VM, Soares MJ, Cross JC, Zamudio S, Illsley NP, Myatt
L, Colvis C, Costantine MM, Haas DM, Sadovsky Y, Weiner C, Rytting E, Bidwell G (2016)
Placental origins of adverse pregnancy outcomes: potential molecular targets: an executive
workshop summary of the Eunice Kennedy Shriver National Institute of Child Health and
Human Development. Am J Obstet Gynecol 215(1 Suppl):S1–S46. https://doi.org/10.1016/j.
ajog.2016.03.001
International Council for Harmonisation of technical requirements for pharmaceuticals for human
use (2017) Draft ICH harmonized guideline. Detection of toxicity to reproduction for human
pharmaceuticals. S5(R3). Current Step 2 draft version dated 5 July 2017. https://database.ich.
org/sites/default/files/S5- R3_EWG_Draft_Guideline.pdf Accessed 2 November 2019
Isaacson CW, Usenko CY, Tanguay RL, Field JA (2017) Quantification of fullerenes by LC/
ESI-MS and its application to in vivo toxicity assays. Anal Chem 79(23):9091–9097. https://
doi.org/10.1021/ac0712289
Jallouk AP, Moley KH, Omurtag K, Hu G, Lanza GM, Wickline SA, Hood JL (2014) Nanoparticle
incorporation of melittin reduces sperm and vaginal epithelium cytotoxicity. PLoS One
9(4):e95411. https://doi.org/10.1371/journal.pone.0095411
Jia HR, Zhu YX, Duan QY, Chen Z, Wu FG (2019) Nanomaterials meet zebrafish: toxicity
evaluation and drug delivery applications. J Control Release 311-312:301–318. https://doi.
org/10.1016/j.jconrel.2019.08.022
Jin Z, Li R, Zhou C, Shi L, Zhang X, Yang Z, Zhang D (2016) Efficient gene knockdown in
mouse oocytes through peptide nanoparticle-mediated SiRNA transfection. PLoS One
11(3):e0150462. https://doi.org/10.1371/journal.pone.0150462
A. G. Cattaneo
Hawkins SJ, Crompton LA, Sood A, Saunders M, Boyle NT, Buckley A, Minogue AM, McComish
SF, Jiménez-Moreno N, Cordero-Llana O, Stathakos P, Gilmore CE, Kelly S, Lane JD, Case
CP, Caldwell MA (2018) Nanoparticle-induced neural toxicity across placental barriers is
mediated by autophagy and dependent on astrocytes. Nat Nanotechnol 13:427–433. https://
doi.org/10.1038/s41565- 018- 0085- 3
He JH, Gao JM, Huang CJ, Li CQ (2014) Zebrafish models for assessing developmental and reproductive toxicity. Neurotoxicol Teratol 42:35–42. https://doi.org/10.1016/j.ntt.2014.01.006
Heinlaan M, Muna M, Knöbel M, Kistler D, Odzak N, Kühnel D, Müller J, Gupta GS, Kumar
A, Shanker R, Sigg L (2016) Natural water as the test medium for ag and CuO nanoparticle
hazard evaluation: an interlaboratory case study. Environ Pollut 216:689–699. https://doi.
org/10.1016/j.envpol.2016.06.033
Higashisaka K, Nagano K, Yoshioka Y, Tsutsumi Y (2017) Nano-safety research: examining the
associations among the biological effects of nanoparticles and their physicochemical properties
and kinetics. Biol Pharm Bull 40(3):243–248. https://doi.org/10.1248/bpb.b16- 00854
Hoelting L, Scheinhardt B, Bondarenko O, Schildknecht S, Kapitza M, Tanavde V, Tan B, Lee
QY, Mecking S, Leist M, Kadereit S (2013) A 3-dimensional human embryonic stem cell
(hESC)-derived model to detect developmental neurotoxicity of nanoparticles. Arch Toxicol
87(4):721–733. https://doi.org/10.1007/s00204- 012- 0984- 2
Hong F, Zhao X, Chen M, Zhou Y, Ze Y, Wang L, Wang Y, Ge Y, Zhang Q, Ye L (2016) TiO2
nanoparticles-induced apoptosis of primary cultured Sertoli cells of mice. J Biomed Mater Res
Part A 2016(104A):124–135. https://doi.org/10.1002/jbm.a.35548
Hsieh MS, Shiao NH, Chan WH (2009) Cytotoxic effects of CdSe quantum dots on maturation of
mouse oocytes, fertilization, and fetal development. Int J Mol Sci 10(5):2122–2135. https://doi.
org/10.3390/ijms10052122
Hu J, Xie C, Ma H, Yang B, Ma PX, Chen YE (2012) Construction of vascular tissues with macroporous nano-fibrous scaffolds and smooth muscle cells enriched from differentiated embryonic
stem cells. PLoS One 7(4):e35580. https://doi.org/10.1371/journal.pone.0035580
Huang JP, Hsieh PC, Chen CY, Wang TY, Chen PC, Liu CC, Chen CC, Chen CP (2015) Nanoparticles
can cross mouse placenta and induce trophoblast apoptosis. Placenta 36(12):1433–1441.
https://doi.org/10.1016/j.placenta.2015.10.007
Ilekis JV, Tsilou E, Fisher S, Abrahams VM, Soares MJ, Cross JC, Zamudio S, Illsley NP, Myatt
L, Colvis C, Costantine MM, Haas DM, Sadovsky Y, Weiner C, Rytting E, Bidwell G (2016)
Placental origins of adverse pregnancy outcomes: potential molecular targets: an executive
workshop summary of the Eunice Kennedy Shriver National Institute of Child Health and
Human Development. Am J Obstet Gynecol 215(1 Suppl):S1–S46. https://doi.org/10.1016/j.
ajog.2016.03.001
International Council for Harmonisation of technical requirements for pharmaceuticals for human
use (2017) Draft ICH harmonized guideline. Detection of toxicity to reproduction for human
pharmaceuticals. S5(R3). Current Step 2 draft version dated 5 July 2017. https://database.ich.
org/sites/default/files/S5- R3_EWG_Draft_Guideline.pdf Accessed 2 November 2019
Isaacson CW, Usenko CY, Tanguay RL, Field JA (2017) Quantification of fullerenes by LC/
ESI-MS and its application to in vivo toxicity assays. Anal Chem 79(23):9091–9097. https://
doi.org/10.1021/ac0712289
Jallouk AP, Moley KH, Omurtag K, Hu G, Lanza GM, Wickline SA, Hood JL (2014) Nanoparticle
incorporation of melittin reduces sperm and vaginal epithelium cytotoxicity. PLoS One
9(4):e95411. https://doi.org/10.1371/journal.pone.0095411
Jia HR, Zhu YX, Duan QY, Chen Z, Wu FG (2019) Nanomaterials meet zebrafish: toxicity
evaluation and drug delivery applications. J Control Release 311-312:301–318. https://doi.
org/10.1016/j.jconrel.2019.08.022
Jin Z, Li R, Zhou C, Shi L, Zhang X, Yang Z, Zhang D (2016) Efficient gene knockdown in
mouse oocytes through peptide nanoparticle-mediated SiRNA transfection. PLoS One
11(3):e0150462. https://doi.org/10.1371/journal.pone.0150462
A. G. Cattaneo