137
Kim YJ, Choi HS, Song MK, Youk DY, Kim JH, Ryu JC (2009) Genotoxicity of aluminum oxide
(Al2O3) nanoparticle in mammalian cell lines. Mol Cell Toxicol 5:172–178
Kuempel ED, Geraci CL, Schulte PA (2012) Risk assessment and risk management of nanomaterials in the workplace: translating research to practice. Ann Occup Hyg 56:491–505
Liu S, Yang Z (2013) Evaluation of the effect of acute and subacute exposure to TiO 2 nanoparticles
on oxidative stress. Methods Mol Biol 1028:135–145
Mallakpour S, Behranvand V (2016) Polymeric nanoparticles: recent development in synthesis and
application. Express Polym Lett 10:895–913
Møller P, Jensen DM, Wils RS, Andersen MHG, Danielsen PH, Roursgaard M (2017) Assessment
of evidence for nanosized titanium dioxide-generated DNA strand breaks and oxidatively damaged DNA in cells and animal models. Nanotoxicology 11:1237–1256
Moreno-Vega AI, Gómez-Quintero T, Nuñez-Anita RE, Acosta-Torres LS, Castaño V (2012)
Polymeric and ceramic nanoparticles in biomedical applications. J Nanotechnol Article ID
936041, 1–10
Murugadoss S, Lison D, Godderis L, Van Den Brule S, Mast J, Brassinne F, Sebaihi N, Hoet PH
(2017) Toxicology of silica nanoparticles: an update. Arch Toxicol 91:2967–3010
Namvar F, Rahman HS, Mohamad R, Azizi S, Tahir PM, Chartrand MS, Yeap SK (2015) Cytotoxic
effects of biosynthesized zinc oxide nanoparticles on murine cell lines. Evid Based Complement
Alternat Med 2015:593014
Nath D, Banerjee P (2013) Green nanotechnology – a new hope for medical biology. Environ
Toxicol Pharmacol 36:997–1014
Ng CT, Yong LQ, Hande MP, Ong CN, Yu LE, Bay BH, Baeg GH (2017) Zinc oxide nanoparticles
exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster. Int J Nanomedicine 12:1621–1637
Oberdorster G (2001) Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ
Health 74:1–8
Oberdörster E (2004) Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the
brain of juvenile largemouth bass. Environ Health Perspect 112:1058–1062
Oberdorster G, Ferin J, Lehnert BE (1994) Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect 102:173–179
Oberdörster G, Oberdörster E, Oberdörster J (2005a) Nanotoxicology: an emerging discipline
evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839
Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn
B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H (2005b) Principles for
characterizing the potential human health effects from exposure to nanomaterials: elements of
a screening strategy. Part Fibre Toxicol 2:1–60
OECD (n.d.) Report in co-operation with the OECD International Futures Programme. Small sizes
that matter: Opportunities and risks of Nanotechnologies, 1–45. https://www.oecd.org/science/
nanosafety/37770473.pdf
Poljsak B, Šuput D, Milisav I (2013) Achieving the balance between reactive oxygen species and
antioxidants: when to use the synthetic antioxidants. Oxidative Med Cell Longev 956792
Pourmand A, Abdollahi M (2012) Current opinion on nanotoxicology. Daru J Pharm Sci 20:95
Radziun E, Dudkiewicz Wilczyńska J, Książek I, Nowak K, Anuszewska EL, Kunicki A, Olszyna
A, Zabkowski T (2011) Assessment of the cytotoxicity of aluminium oxide nanoparticles on
selected mammalian cells. Toxicol In Vitro 25:1694–1700
Ray PC, Yu H, Fu PP (2009) Toxicity and environmental risks of nanomaterials: challenges and
future needs. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:1–35
Sadeghi L, Tanwir F, Yousefi Babadi V (2015) In vitro toxicity of iron oxide nanoparticle: oxidative damages on Hep G2 cells. Exp Toxicol Pathol 67:197–203
Sager TM, Kommineni C, Castranova V (2008) Pulmonary response to intratracheal instillation
of ultrafine versus fine titanium dioxide: role of particle surface area. Part Fibre Toxicol 5:17
SCENIHR (Scientific Committee on Emerging and Newly Identified Health Risks) (2006) Opinion
on the appropriateness of existing methodologies to assess the potential risks associated with
engineered and adventitious products of nanotechnology, 10 March 2006, http://ec.europa.eu/
health/scientific_committees/emerging/opinions/scenihr_opinions_en.htm
5 Nanomaterials Causing Cellular Toxicity and Genotoxicity
Kim YJ, Choi HS, Song MK, Youk DY, Kim JH, Ryu JC (2009) Genotoxicity of aluminum oxide
(Al2O3) nanoparticle in mammalian cell lines. Mol Cell Toxicol 5:172–178
Kuempel ED, Geraci CL, Schulte PA (2012) Risk assessment and risk management of nanomaterials in the workplace: translating research to practice. Ann Occup Hyg 56:491–505
Liu S, Yang Z (2013) Evaluation of the effect of acute and subacute exposure to TiO 2 nanoparticles
on oxidative stress. Methods Mol Biol 1028:135–145
Mallakpour S, Behranvand V (2016) Polymeric nanoparticles: recent development in synthesis and
application. Express Polym Lett 10:895–913
Møller P, Jensen DM, Wils RS, Andersen MHG, Danielsen PH, Roursgaard M (2017) Assessment
of evidence for nanosized titanium dioxide-generated DNA strand breaks and oxidatively damaged DNA in cells and animal models. Nanotoxicology 11:1237–1256
Moreno-Vega AI, Gómez-Quintero T, Nuñez-Anita RE, Acosta-Torres LS, Castaño V (2012)
Polymeric and ceramic nanoparticles in biomedical applications. J Nanotechnol Article ID
936041, 1–10
Murugadoss S, Lison D, Godderis L, Van Den Brule S, Mast J, Brassinne F, Sebaihi N, Hoet PH
(2017) Toxicology of silica nanoparticles: an update. Arch Toxicol 91:2967–3010
Namvar F, Rahman HS, Mohamad R, Azizi S, Tahir PM, Chartrand MS, Yeap SK (2015) Cytotoxic
effects of biosynthesized zinc oxide nanoparticles on murine cell lines. Evid Based Complement
Alternat Med 2015:593014
Nath D, Banerjee P (2013) Green nanotechnology – a new hope for medical biology. Environ
Toxicol Pharmacol 36:997–1014
Ng CT, Yong LQ, Hande MP, Ong CN, Yu LE, Bay BH, Baeg GH (2017) Zinc oxide nanoparticles
exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster. Int J Nanomedicine 12:1621–1637
Oberdorster G (2001) Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ
Health 74:1–8
Oberdörster E (2004) Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the
brain of juvenile largemouth bass. Environ Health Perspect 112:1058–1062
Oberdorster G, Ferin J, Lehnert BE (1994) Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect 102:173–179
Oberdörster G, Oberdörster E, Oberdörster J (2005a) Nanotoxicology: an emerging discipline
evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839
Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn
B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H (2005b) Principles for
characterizing the potential human health effects from exposure to nanomaterials: elements of
a screening strategy. Part Fibre Toxicol 2:1–60
OECD (n.d.) Report in co-operation with the OECD International Futures Programme. Small sizes
that matter: Opportunities and risks of Nanotechnologies, 1–45. https://www.oecd.org/science/
nanosafety/37770473.pdf
Poljsak B, Šuput D, Milisav I (2013) Achieving the balance between reactive oxygen species and
antioxidants: when to use the synthetic antioxidants. Oxidative Med Cell Longev 956792
Pourmand A, Abdollahi M (2012) Current opinion on nanotoxicology. Daru J Pharm Sci 20:95
Radziun E, Dudkiewicz Wilczyńska J, Książek I, Nowak K, Anuszewska EL, Kunicki A, Olszyna
A, Zabkowski T (2011) Assessment of the cytotoxicity of aluminium oxide nanoparticles on
selected mammalian cells. Toxicol In Vitro 25:1694–1700
Ray PC, Yu H, Fu PP (2009) Toxicity and environmental risks of nanomaterials: challenges and
future needs. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:1–35
Sadeghi L, Tanwir F, Yousefi Babadi V (2015) In vitro toxicity of iron oxide nanoparticle: oxidative damages on Hep G2 cells. Exp Toxicol Pathol 67:197–203
Sager TM, Kommineni C, Castranova V (2008) Pulmonary response to intratracheal instillation
of ultrafine versus fine titanium dioxide: role of particle surface area. Part Fibre Toxicol 5:17
SCENIHR (Scientific Committee on Emerging and Newly Identified Health Risks) (2006) Opinion
on the appropriateness of existing methodologies to assess the potential risks associated with
engineered and adventitious products of nanotechnology, 10 March 2006, http://ec.europa.eu/
health/scientific_committees/emerging/opinions/scenihr_opinions_en.htm
5 Nanomaterials Causing Cellular Toxicity and Genotoxicity