10.4 Product Risk Assessment
255
Task: Use this EFSA spreadsheet-based exposure assessment tool to complete the
following:
(a) Calculate the total acute and longer-term systemic exposures [mg ASM/kg
body weight/d] for an operator spraying tomatoes (a fruiting vegetable) with
a handheld sprayer. Compare exposure estimates without and with personal
protective equipment (PPE). Use the data provided in Table 10.7, and also
consider the following:
• ASM is a substance of low volatility and the product Bion ® is a wettable
granule.
• The reference value non-acutely toxic active substances (RVNAS) is equal
to the set acceptable operator exposure level (AOEL) as published in EFSA
(2014a).
• An average operator’s weight is 60 kg.
• When an operator wears PPE, this includes gloves, workwear, and a hood and
visor during both mixing and loading as well as application. A water-soluble
bag is used.
Note that Bion’s ® product label requires appropriate clothing and PPE to be
worn during application. The scenario without using PPE is entirely hypothetical.
(b) Which pathway is estimated to be the largest contributor to the systemic longerterm exposure to ASM?
(c) For which application route does PPE provide the most benefit? Which PPE is
that?
10.4.2.3 Human Exposure: Dietary
In addition to occupational exposure, dietary exposure of consumers can also be
investigated. Here, the aim will be to assess the influence that the amount of
pesticide residue remaining on a food product (crop) has on the resulting dietary
exposure. These residues are regulated through maximum residue levels (MRLs).
On the basis of dietary data from the EFSA PRIMo 3.1 model (Anastassiadou et al.,
2019) and current MRLs from the EU pesticides database (European Commission,
2019a), the influence of MRLs for ASM on the dietary predicted daily intake (PDI)
of different age groups will be investigated. Guidance documentation for the EFSA
tool has been published (Anastassiadou et al., 2019), and the tool file itself can be
downloaded from that document’s supporting information.
Task: Use data from the EFSA PRIMo 3.1 model and EU pesticides database to
complete the following:
255
Task: Use this EFSA spreadsheet-based exposure assessment tool to complete the
following:
(a) Calculate the total acute and longer-term systemic exposures [mg ASM/kg
body weight/d] for an operator spraying tomatoes (a fruiting vegetable) with
a handheld sprayer. Compare exposure estimates without and with personal
protective equipment (PPE). Use the data provided in Table 10.7, and also
consider the following:
• ASM is a substance of low volatility and the product Bion ® is a wettable
granule.
• The reference value non-acutely toxic active substances (RVNAS) is equal
to the set acceptable operator exposure level (AOEL) as published in EFSA
(2014a).
• An average operator’s weight is 60 kg.
• When an operator wears PPE, this includes gloves, workwear, and a hood and
visor during both mixing and loading as well as application. A water-soluble
bag is used.
Note that Bion’s ® product label requires appropriate clothing and PPE to be
worn during application. The scenario without using PPE is entirely hypothetical.
(b) Which pathway is estimated to be the largest contributor to the systemic longerterm exposure to ASM?
(c) For which application route does PPE provide the most benefit? Which PPE is
that?
10.4.2.3 Human Exposure: Dietary
In addition to occupational exposure, dietary exposure of consumers can also be
investigated. Here, the aim will be to assess the influence that the amount of
pesticide residue remaining on a food product (crop) has on the resulting dietary
exposure. These residues are regulated through maximum residue levels (MRLs).
On the basis of dietary data from the EFSA PRIMo 3.1 model (Anastassiadou et al.,
2019) and current MRLs from the EU pesticides database (European Commission,
2019a), the influence of MRLs for ASM on the dietary predicted daily intake (PDI)
of different age groups will be investigated. Guidance documentation for the EFSA
tool has been published (Anastassiadou et al., 2019), and the tool file itself can be
downloaded from that document’s supporting information.
Task: Use data from the EFSA PRIMo 3.1 model and EU pesticides database to
complete the following: