by using a stopwatch. The individual drops should be added
within a set of introduction time to minimize bead agglomeration. Sodium metabisulfite was added to reduce the adherence
of the beads to one another.
6. The irradiation dose (kGy) was chosen at 10 kGy since higher
radiation dose would cause more scission and oxidative degradation leading to a dilution of the viscous CMSP solution.
Furthermore, the active ingredient 5-ASA undergoes thermal
and radio degradation, reducing its effectiveness when exposed
to higher irradiation doses. Lower kGy doses would not provide sufficient cross-linking rather than predomination of
scission.
7. Higher drug loadings could distort the bead shape, possibly
due to disruption of the matrix by the drug molecules during
bead formation and also by exhibiting more resistance when
extruding through the needle. The average diameter of 50–100
beads should be measured to optimize the size of the beads.
Thus, the unloaded beads observed in this study will be smaller
than the drug-loaded beads. The average size and size deviation
will increase with increasing 5-ASA loading. It could be due to
an increase in viscosity because of higher drug concentration in
the polymeric mixture.
8. The pectin proportion cannot exceed 5% (w/v) as its gelling
properties would cause the solution to be excessively viscous.
9. The solubility of diclofenac sodium is dependent on the pH of
the dissolution medium. It is soluble at pH 5–8, whereas an
acidified dissolution medium would result in precipitation of
the diclofenac salt.
10. Subjected to electron beam irradiation to cross-link for the
second time to tighten the matrix by increasing the extent of
the cross-linking and hold the drug molecules tightly in the
polymer matrix.
11. Micronization of ibuprofen would improve the encapsulation
efficiency by increasing the surface area of the solid drug
particles.
12. Measuring the electrophoretic mobility of the gelatine and
carboxymethylcellulose as a function of pH and ionic strength
would ensure that the optimum conditions for the highest
degree of coacervation would be met. Approaching zero
mobility charge would prevent the presence of excessive polymers in the coacervate medium.
13. Ferric chloride is toxic for human consumption; thus, residual
presence on the sample should be investigated using gas
chromatography.
180
Janarthanan Pushpamalar et al.
within a set of introduction time to minimize bead agglomeration. Sodium metabisulfite was added to reduce the adherence
of the beads to one another.
6. The irradiation dose (kGy) was chosen at 10 kGy since higher
radiation dose would cause more scission and oxidative degradation leading to a dilution of the viscous CMSP solution.
Furthermore, the active ingredient 5-ASA undergoes thermal
and radio degradation, reducing its effectiveness when exposed
to higher irradiation doses. Lower kGy doses would not provide sufficient cross-linking rather than predomination of
scission.
7. Higher drug loadings could distort the bead shape, possibly
due to disruption of the matrix by the drug molecules during
bead formation and also by exhibiting more resistance when
extruding through the needle. The average diameter of 50–100
beads should be measured to optimize the size of the beads.
Thus, the unloaded beads observed in this study will be smaller
than the drug-loaded beads. The average size and size deviation
will increase with increasing 5-ASA loading. It could be due to
an increase in viscosity because of higher drug concentration in
the polymeric mixture.
8. The pectin proportion cannot exceed 5% (w/v) as its gelling
properties would cause the solution to be excessively viscous.
9. The solubility of diclofenac sodium is dependent on the pH of
the dissolution medium. It is soluble at pH 5–8, whereas an
acidified dissolution medium would result in precipitation of
the diclofenac salt.
10. Subjected to electron beam irradiation to cross-link for the
second time to tighten the matrix by increasing the extent of
the cross-linking and hold the drug molecules tightly in the
polymer matrix.
11. Micronization of ibuprofen would improve the encapsulation
efficiency by increasing the surface area of the solid drug
particles.
12. Measuring the electrophoretic mobility of the gelatine and
carboxymethylcellulose as a function of pH and ionic strength
would ensure that the optimum conditions for the highest
degree of coacervation would be met. Approaching zero
mobility charge would prevent the presence of excessive polymers in the coacervate medium.
13. Ferric chloride is toxic for human consumption; thus, residual
presence on the sample should be investigated using gas
chromatography.
180
Janarthanan Pushpamalar et al.