3. A 5-ASA concentration exceeding 30% causes the formation of
flattened beads that adhere strongly to the surface of the drying
plates.
4. A 5% AlCl 3 cross-linker solution was used since elevated concentrations cause too rapid cross-linking, leaving the beads
matrix too compact, resulting in a drug loading efficiency
reduction.
5. The limiting factor to the formation of uniform and spherically
shaped bead is defined by the inability to control the flow rate
and pressure parameters exerted by the manual ionotropic
gelation. The flow rate of the drop addition can be regulated
Fig. 2 The hydrogel beads of teardrop-shaped formed using various carboxymethylcellulose (CMC) concentrations by ionotropic cross-linking
Fig. 3 The stability of the 5-ASA in different pH media
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flattened beads that adhere strongly to the surface of the drying
plates.
4. A 5% AlCl 3 cross-linker solution was used since elevated concentrations cause too rapid cross-linking, leaving the beads
matrix too compact, resulting in a drug loading efficiency
reduction.
5. The limiting factor to the formation of uniform and spherically
shaped bead is defined by the inability to control the flow rate
and pressure parameters exerted by the manual ionotropic
gelation. The flow rate of the drop addition can be regulated
Fig. 2 The hydrogel beads of teardrop-shaped formed using various carboxymethylcellulose (CMC) concentrations by ionotropic cross-linking
Fig. 3 The stability of the 5-ASA in different pH media
Hydrogel Beads of Natural Polymers for Colon-Targeted Drug Delivery
179