46
X. Feng et al.
Table 2.10 Hydrogenation of 1,4-benzoxazines 30
N
O
R
R''
R'
N
H
O
R
R''
R'
B(C 6 F 5 ) 3
(2.5-5 mol %)
H 2 (20 bar), toluene
30
31
Entry product
cat. loading
(mol %)
yield
(%)
1
31a
N
H
O
Ph
2.5
93
2
31b
N
H
O
OMe
2.5
99
3
31c
N
H
O
Ph
2.5
98
4
31d
N
H
O
F
2.5
93
5
31e
N
H
O
2.5
99
6
31f
N
H
O
S
2.5
99
7
31g
N
H
O
Ph
Cl
2.5
99
8
31h
N
H
O
Ph
Me
2.5
99
9
31i
N
H
O
Ph
Ph
5
9 9
10
31j
N
H
O
Ph
Me
5
9 8