Chapter 2
Frustrated Lewis Pair Catalyzed
Asymmetric Reactions
Xiangqing Feng, Wei Meng, and Haifeng Du
Abstract As a lately emerging area, frustrated Lewis pair chemistry provides the
most effective way for metal-free catalytic reductions, and a wide range of unsaturated compounds have been successfully reduced. However, the asymmetric catalytic
reduction is still in its initial stage, and some formidable challenges still remain. The
development of highly effective chiral FLP catalysts and their applications in asymmetric catalysis are two very important subjects in this field. This chapter will summarize the advances for chiral FLP catalysts and metal-free asymmetric reductions
including hydrogenations, Piers-type hydrosilylations, and transfer hydrogenations
in the past six years.
Keywords Frustrated Lewis pairs · Asymmetric catalysis · Chiral boranes · Chiral
Lewis bases · Asymmetric hydrogenation · Asymmetric hydrosilylation ·
Asymmetric transfer hydrogenation
Abbreviations
Ac
Acetyl
Ar
Aryl
Atm
Atmosphere
Barton’s base 2-tert-butyl-1,1,3,3-tetramethylguanidine
X. Feng · W. Meng · H. Du (B)
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular
Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190,
China
e-mail: haifengdu@iccas.ac.cn
X. Feng
e-mail: fxq@iccas.ac.cn
W. Meng
e-mail: mengwei@iccas.ac.cn
University of Chinese Academy of Sciences, Beijing 100049, China
© Springer Nature Switzerland AG 2021
J. Chris Slootweg and A. R. Jupp (eds.), Frustrated Lewis Pairs,
Molecular Catalysis 2, https://doi.org/10.1007/978-3-030-58888-5_2
29
Frustrated Lewis Pair Catalyzed
Asymmetric Reactions
Xiangqing Feng, Wei Meng, and Haifeng Du
Abstract As a lately emerging area, frustrated Lewis pair chemistry provides the
most effective way for metal-free catalytic reductions, and a wide range of unsaturated compounds have been successfully reduced. However, the asymmetric catalytic
reduction is still in its initial stage, and some formidable challenges still remain. The
development of highly effective chiral FLP catalysts and their applications in asymmetric catalysis are two very important subjects in this field. This chapter will summarize the advances for chiral FLP catalysts and metal-free asymmetric reductions
including hydrogenations, Piers-type hydrosilylations, and transfer hydrogenations
in the past six years.
Keywords Frustrated Lewis pairs · Asymmetric catalysis · Chiral boranes · Chiral
Lewis bases · Asymmetric hydrogenation · Asymmetric hydrosilylation ·
Asymmetric transfer hydrogenation
Abbreviations
Ac
Acetyl
Ar
Aryl
Atm
Atmosphere
Barton’s base 2-tert-butyl-1,1,3,3-tetramethylguanidine
X. Feng · W. Meng · H. Du (B)
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular
Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190,
China
e-mail: haifengdu@iccas.ac.cn
X. Feng
e-mail: fxq@iccas.ac.cn
W. Meng
e-mail: mengwei@iccas.ac.cn
University of Chinese Academy of Sciences, Beijing 100049, China
© Springer Nature Switzerland AG 2021
J. Chris Slootweg and A. R. Jupp (eds.), Frustrated Lewis Pairs,
Molecular Catalysis 2, https://doi.org/10.1007/978-3-030-58888-5_2
29