17. Antoine EE, Vlachos PP, Rylander MN (2014) Review of collagen I hydrogels for
bioengineered tissue microenvironments: characterization of mechanics, structure, and transport. Tissue Eng Part B Rev 20:683–696. https://doi.org/10.1089/ten.TEB.2014.0086
18. Khaing ZZ, Schmidt CE (2012) Advances in natural biomaterials for nerve tissue repair.
Neurosci Lett 519:103–114. https://doi.org/10.1016/j.neulet.2012.02.027
19. Brännvall K, Bergman K, Wallenquist U, Svahn S, Bowden T, Hilborn J et al (2007) Enhanced
neuronal differentiation in a three-dimensional collagen-hyaluronan matrix. J Neurosci Res
85:2138–2146. https://doi.org/10.1002/jnr.21358
20. Bozkurt A, Brook GA, Moellers S, Lassner F, Sellhaus B, Weis J et al (2007) In vitro
assessment of axonal growth using dorsal root ganglia explants in a novel three-dimensional
collagen matrix. Tissue Eng 13:2971–2979. https://doi.org/10.1089/ten.2007.0116
21. Blewitt MJ, Willits RK (2007) The effect of soluble peptide sequences on neurite extension on
2D collagen substrates and within 3D collagen gels. Ann Biomed Eng 35:2159–2167. https://
doi.org/10.1007/s10439-007-9389-4
22. Deister C, Aljabari S, Schmidt CE (2007) Effects of collagen I, fibronectin, laminin and
hyaluronic acid concentration in multi-component gels on neurite extension. J Biomater Sci
Polym Ed 18:983–997. https://doi.org/10.1163/156856207781494377
23. Kofron CM, Fong VJ, Hoffman-Kim D (2009) Neurite outgrowth at the interface of 2D and 3D
growth environments. J Neural Eng 6:016002. https://doi.org/10.1088/1741-2560/6/1/016002
24. Hiraoka M, Kato K, Nakaji-Hirabayashi T, Iwata H (2009) Enhanced survival of neural cells
embedded in hydrogels composed of collagen and laminin-derived cell adhesive peptide.
Bioconjug Chem 20:976–983. https://doi.org/10.1021/bc9000068
25. Kim J-M, Park WH, Min B-M (2005) The PPFLMLLKGSTR motif in globular domain 3 of the
human laminin-5 alpha3 chain is crucial for integrin alpha3beta1 binding and cell adhesion. Exp
Cell Res 304:317–327. https://doi.org/10.1016/j.yexcr.2004.11.009
26. Edick MJ, Tesfay L, Lamb LE, Knudsen BS, Miranti CK (2007) Inhibition of integrin-mediated
crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic
prostate epithelial cells induces caspase-independent death. Mol Biol Cell 18:2481–2490.
https://doi.org/10.1091/mbc.e06-04-0261
27. Ekblom M, Falk M, Salmivirta K, Durbeej M, Ekblom P (1998) Laminin isoforms and
epithelial development. Ann N Y Acad Sci 857:194–211. https://doi.org/10.1111/j.17496632.1998.tb10117.x
28. Galliano MF, Aberdam D, Aguzzi A, Ortonne JP, Meneguzzi G (1995) Cloning and complete
primary structure of the mouse laminin alpha 3 chain. Distinct expression pattern of the laminin
alpha 3A and alpha 3B chain isoforms. J Biol Chem 270:21820–21826. https://doi.org/10.1074/
jbc.270.37.21820
29. Hall PE, Lathia JD, Miller NG, Caldwell MA, ffrench-Constant C (2006) Integrins are markers
of human neural stem cells. Stem Cells 24:2078–2084. https://doi.org/10.1634/stemcells.20050595
30. Schmid RS, Anton ES (2003) Role of integrins in the development of the cerebral cortex. Cereb
Cortex 13:219–224. https://doi.org/10.1093/cercor/13.3.219
31. Tarone G, Hirsch E, Brancaccio M, De Acetis M, Barberis L, Balzac F, Retta SF, Botta C,
Altruda F, Silengo L (2000) Integrin function and regulation in development. Int J Dev Biol
44:725–731
32. Yao L, Damodaran G, Nikolskaya N, Gorman AM, Windebank A, Pandit A (2010) The effect
of laminin peptide gradient in enzymatically cross-linked collagen scaffolds on neurite growth.
J Biomed Mater Res A 92:484–492. https://doi.org/10.1002/jbm.a.32359
33. Lee JH, Yu H-S, Lee G-S, Ji A, Hyun JK, Kim H-W (2011) Collagen gel three-dimensional
matrices combined with adhesive proteins stimulate neuronal differentiation of mesenchymal
stem cells. J R Soc Interface 8:998–1010. https://doi.org/10.1098/rsif.2010.0613
34. Swindle-Reilly KE, Papke JB, Kutosky HP, Throm A, Hammer JA, Harkins AB, Willits RK
(2012) The impact of laminin on 3D neurite extension in collagen gels. J Neural Eng 9:046007.
https://doi.org/10.1088/1741-2560/9/4/046007
Self-Healing Collagen-Based Hydrogel for Brain Injury Therapy
377
bioengineered tissue microenvironments: characterization of mechanics, structure, and transport. Tissue Eng Part B Rev 20:683–696. https://doi.org/10.1089/ten.TEB.2014.0086
18. Khaing ZZ, Schmidt CE (2012) Advances in natural biomaterials for nerve tissue repair.
Neurosci Lett 519:103–114. https://doi.org/10.1016/j.neulet.2012.02.027
19. Brännvall K, Bergman K, Wallenquist U, Svahn S, Bowden T, Hilborn J et al (2007) Enhanced
neuronal differentiation in a three-dimensional collagen-hyaluronan matrix. J Neurosci Res
85:2138–2146. https://doi.org/10.1002/jnr.21358
20. Bozkurt A, Brook GA, Moellers S, Lassner F, Sellhaus B, Weis J et al (2007) In vitro
assessment of axonal growth using dorsal root ganglia explants in a novel three-dimensional
collagen matrix. Tissue Eng 13:2971–2979. https://doi.org/10.1089/ten.2007.0116
21. Blewitt MJ, Willits RK (2007) The effect of soluble peptide sequences on neurite extension on
2D collagen substrates and within 3D collagen gels. Ann Biomed Eng 35:2159–2167. https://
doi.org/10.1007/s10439-007-9389-4
22. Deister C, Aljabari S, Schmidt CE (2007) Effects of collagen I, fibronectin, laminin and
hyaluronic acid concentration in multi-component gels on neurite extension. J Biomater Sci
Polym Ed 18:983–997. https://doi.org/10.1163/156856207781494377
23. Kofron CM, Fong VJ, Hoffman-Kim D (2009) Neurite outgrowth at the interface of 2D and 3D
growth environments. J Neural Eng 6:016002. https://doi.org/10.1088/1741-2560/6/1/016002
24. Hiraoka M, Kato K, Nakaji-Hirabayashi T, Iwata H (2009) Enhanced survival of neural cells
embedded in hydrogels composed of collagen and laminin-derived cell adhesive peptide.
Bioconjug Chem 20:976–983. https://doi.org/10.1021/bc9000068
25. Kim J-M, Park WH, Min B-M (2005) The PPFLMLLKGSTR motif in globular domain 3 of the
human laminin-5 alpha3 chain is crucial for integrin alpha3beta1 binding and cell adhesion. Exp
Cell Res 304:317–327. https://doi.org/10.1016/j.yexcr.2004.11.009
26. Edick MJ, Tesfay L, Lamb LE, Knudsen BS, Miranti CK (2007) Inhibition of integrin-mediated
crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic
prostate epithelial cells induces caspase-independent death. Mol Biol Cell 18:2481–2490.
https://doi.org/10.1091/mbc.e06-04-0261
27. Ekblom M, Falk M, Salmivirta K, Durbeej M, Ekblom P (1998) Laminin isoforms and
epithelial development. Ann N Y Acad Sci 857:194–211. https://doi.org/10.1111/j.17496632.1998.tb10117.x
28. Galliano MF, Aberdam D, Aguzzi A, Ortonne JP, Meneguzzi G (1995) Cloning and complete
primary structure of the mouse laminin alpha 3 chain. Distinct expression pattern of the laminin
alpha 3A and alpha 3B chain isoforms. J Biol Chem 270:21820–21826. https://doi.org/10.1074/
jbc.270.37.21820
29. Hall PE, Lathia JD, Miller NG, Caldwell MA, ffrench-Constant C (2006) Integrins are markers
of human neural stem cells. Stem Cells 24:2078–2084. https://doi.org/10.1634/stemcells.20050595
30. Schmid RS, Anton ES (2003) Role of integrins in the development of the cerebral cortex. Cereb
Cortex 13:219–224. https://doi.org/10.1093/cercor/13.3.219
31. Tarone G, Hirsch E, Brancaccio M, De Acetis M, Barberis L, Balzac F, Retta SF, Botta C,
Altruda F, Silengo L (2000) Integrin function and regulation in development. Int J Dev Biol
44:725–731
32. Yao L, Damodaran G, Nikolskaya N, Gorman AM, Windebank A, Pandit A (2010) The effect
of laminin peptide gradient in enzymatically cross-linked collagen scaffolds on neurite growth.
J Biomed Mater Res A 92:484–492. https://doi.org/10.1002/jbm.a.32359
33. Lee JH, Yu H-S, Lee G-S, Ji A, Hyun JK, Kim H-W (2011) Collagen gel three-dimensional
matrices combined with adhesive proteins stimulate neuronal differentiation of mesenchymal
stem cells. J R Soc Interface 8:998–1010. https://doi.org/10.1098/rsif.2010.0613
34. Swindle-Reilly KE, Papke JB, Kutosky HP, Throm A, Hammer JA, Harkins AB, Willits RK
(2012) The impact of laminin on 3D neurite extension in collagen gels. J Neural Eng 9:046007.
https://doi.org/10.1088/1741-2560/9/4/046007
Self-Healing Collagen-Based Hydrogel for Brain Injury Therapy
377