different applications, it is foreseeable that the development and adaptation of these
dynamic chemistries will continue to play an ever-increasing role in the design of
self-healing chemically cross-linked hydrogels.
References
1. Kopeček J (2007) Hydrogel biomaterials: a smart future? Biomaterials 28:5185–5192. https://
doi.org/10.1016/j.biomaterials.2007.07.044
2. Hoffman AS (2012) Hydrogels for biomedical applications. Adv Drug Deliv Rev 64:18–23.
https://doi.org/10.1016/J.ADDR.2012.09.010
3. Shoichet MS (2010) Polymer scaffolds for biomaterials applications. Macromolecules
43:581–591. https://doi.org/10.1021/ma901530r
4. Taylor DL, in het Panhuis M (2016) Self-healing hydrogels. Adv Mater 28:9060–9093. https://
doi.org/10.1002/adma.201601613
5. Talebian S, Mehrali M, Taebnia N, Pennisi CP, Kadumudi FB, Forough J, Hasanv M,
Nikkhah M, Akbari M, Orive G, Dolatshahi-Pirouz A (2019) Self-healing hydrogels: the next
paradigm shift in tissue engineering ? Adv Sci 6:1801664. https://doi.org/10.1002/advs.
201801664
6. Wang W, Narain R, Zeng H (2018) Rational design of self-healing tough hydrogels: a mini
review. Front Chem 6:1–9. https://doi.org/10.3389/fchem.2018.00497
7. Okay O (2019) Semicrystalline physical hydrogels with shape-memory and self-healing properties. J Mater Chem B 7:1581–1596. https://doi.org/10.1039/C8TB02767F
8. Wang W, Zhang Y, Liu W (2017) Bioinspired fabrication of high strength hydrogels from
non-covalent interactions. Prog Polym Sci 71:1–25. https://doi.org/10.1016/j.progpolymsci.
2017.04.001
9. Sun TL, Kurokawa T, Kuroda S, Ihsan AB, Akasaki T, Sato K, Haque MA, Nakajima T, Gong
JP (2013) Physical hydrogels composed of polyampholytes demonstrate high toughness and
viscoelasticity. Nat Mater 12:932–937. https://doi.org/10.1038/nmat3713
10. Huang Q, Zou Y, Arno MC, Chen S, Wang T, Gao J, Dove AP, Du J (2017) Hydrogel scaffolds
for differentiation of adipose-derived stem cells. Chem Soc Rev 46:6255–6275. https://doi.org/
10.1039/c6cs00052e
11. Belowich ME, Stoddart JF (2012) Dynamic imine chemistry. Chem Soc Rev 41:2003. https://
doi.org/10.1039/c2cs15305j
12. Zhang Y, Tao L, Li S, Wei Y (2011) Synthesis of multiresponsive and dynamic chitosan-based
hydrogels for controlled release of bioactive molecules. Biomacromolecules 12:2894–2901.
https://doi.org/10.1021/bm200423f
13. Zhang Y, Yang B, Zhang X, Xu L, Tao L, Li S, Wei Y (2012) A magnetic self-healing hydrogel.
Chem Commun 48:9305–9307. https://doi.org/10.1039/c2cc34745h
14. Yang B, Zhang Y, Zhang X, Tao L, Li S, Wei Y (2012) Facilely prepared inexpensive and
biocompatible self-healing hydrogel: a new injectable cell therapy carrier. Polym Chem
3:3235–3238. https://doi.org/10.1039/c2py20627g
15. Tseng TC, Tao L, Hsieh FY, Wei Y, Chiu IM, Hsu SH (2015) An injectable, self-healing
hydrogel to repair the central nervous system. Adv Mater 27:3518–3524. https://doi.org/10.
1002/adma.201500762
16. Wei Z, Zhao J, Chen YM, Zhang P, Zhang Q (2016) Self-healing polysaccharide-based
hydrogels as injectable carriers for neural stem cells. Sci Rep 6:1–12. https://doi.org/10.1038/
srep37841
17. Dong R, Zhao X, Guo B, Ma PX (2016) Self-healing conductive injectable hydrogels with
antibacterial activity as cell delivery carrier for cardiac cell therapy. ACS Appl Mater Interfaces
8:17138–17150. https://doi.org/10.1021/acsami.6b04911
290
R. Kilic and A. Sanyal
dynamic chemistries will continue to play an ever-increasing role in the design of
self-healing chemically cross-linked hydrogels.
References
1. Kopeček J (2007) Hydrogel biomaterials: a smart future? Biomaterials 28:5185–5192. https://
doi.org/10.1016/j.biomaterials.2007.07.044
2. Hoffman AS (2012) Hydrogels for biomedical applications. Adv Drug Deliv Rev 64:18–23.
https://doi.org/10.1016/J.ADDR.2012.09.010
3. Shoichet MS (2010) Polymer scaffolds for biomaterials applications. Macromolecules
43:581–591. https://doi.org/10.1021/ma901530r
4. Taylor DL, in het Panhuis M (2016) Self-healing hydrogels. Adv Mater 28:9060–9093. https://
doi.org/10.1002/adma.201601613
5. Talebian S, Mehrali M, Taebnia N, Pennisi CP, Kadumudi FB, Forough J, Hasanv M,
Nikkhah M, Akbari M, Orive G, Dolatshahi-Pirouz A (2019) Self-healing hydrogels: the next
paradigm shift in tissue engineering ? Adv Sci 6:1801664. https://doi.org/10.1002/advs.
201801664
6. Wang W, Narain R, Zeng H (2018) Rational design of self-healing tough hydrogels: a mini
review. Front Chem 6:1–9. https://doi.org/10.3389/fchem.2018.00497
7. Okay O (2019) Semicrystalline physical hydrogels with shape-memory and self-healing properties. J Mater Chem B 7:1581–1596. https://doi.org/10.1039/C8TB02767F
8. Wang W, Zhang Y, Liu W (2017) Bioinspired fabrication of high strength hydrogels from
non-covalent interactions. Prog Polym Sci 71:1–25. https://doi.org/10.1016/j.progpolymsci.
2017.04.001
9. Sun TL, Kurokawa T, Kuroda S, Ihsan AB, Akasaki T, Sato K, Haque MA, Nakajima T, Gong
JP (2013) Physical hydrogels composed of polyampholytes demonstrate high toughness and
viscoelasticity. Nat Mater 12:932–937. https://doi.org/10.1038/nmat3713
10. Huang Q, Zou Y, Arno MC, Chen S, Wang T, Gao J, Dove AP, Du J (2017) Hydrogel scaffolds
for differentiation of adipose-derived stem cells. Chem Soc Rev 46:6255–6275. https://doi.org/
10.1039/c6cs00052e
11. Belowich ME, Stoddart JF (2012) Dynamic imine chemistry. Chem Soc Rev 41:2003. https://
doi.org/10.1039/c2cs15305j
12. Zhang Y, Tao L, Li S, Wei Y (2011) Synthesis of multiresponsive and dynamic chitosan-based
hydrogels for controlled release of bioactive molecules. Biomacromolecules 12:2894–2901.
https://doi.org/10.1021/bm200423f
13. Zhang Y, Yang B, Zhang X, Xu L, Tao L, Li S, Wei Y (2012) A magnetic self-healing hydrogel.
Chem Commun 48:9305–9307. https://doi.org/10.1039/c2cc34745h
14. Yang B, Zhang Y, Zhang X, Tao L, Li S, Wei Y (2012) Facilely prepared inexpensive and
biocompatible self-healing hydrogel: a new injectable cell therapy carrier. Polym Chem
3:3235–3238. https://doi.org/10.1039/c2py20627g
15. Tseng TC, Tao L, Hsieh FY, Wei Y, Chiu IM, Hsu SH (2015) An injectable, self-healing
hydrogel to repair the central nervous system. Adv Mater 27:3518–3524. https://doi.org/10.
1002/adma.201500762
16. Wei Z, Zhao J, Chen YM, Zhang P, Zhang Q (2016) Self-healing polysaccharide-based
hydrogels as injectable carriers for neural stem cells. Sci Rep 6:1–12. https://doi.org/10.1038/
srep37841
17. Dong R, Zhao X, Guo B, Ma PX (2016) Self-healing conductive injectable hydrogels with
antibacterial activity as cell delivery carrier for cardiac cell therapy. ACS Appl Mater Interfaces
8:17138–17150. https://doi.org/10.1021/acsami.6b04911
290
R. Kilic and A. Sanyal