Automated 96 wells platform
of random combinations
of substrates (pair-wise)
O
R
Y
R
N
R
R
O
R
R
OH
R
OH
R
OH
R
OH
R
OH
R
OH
R
R
R
R
R
R
OH
R
OH
R
OH
R
R
R
R
R
R
R
R
R
R
R
N
R
N
R
N
R
N
R
N
R
N
R
N
R
O
R
O
R
O
R
O
R
O
R
Y
O
R
Y
O
R
Y
O
R
Y
R
R
R
R
R
X
Y
R
X
Y
R
X
Y
R
X
Y
R
’R
N
R'
R
’R
N
R'
R
’R
N
R'
R
’R
N
R'
R
X
Y
R
Add catalyst
GC-MS
anaylsis
Identify
novel
reactivity
Reactivity
optimization
CN
EWG
Ir(ppy)
3
R
N
R
R
EWG
light
32 examples, upto 98% yield
Fig. 5
Reaction discovery by accelerated serendipity
Ligand Design for Asymmetric Catalysis: Combining Mechanistic and. . .
163