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V. Laxmi et al.
15. Laurell, T., Petersson, F., Nilsson, A.: Chip integrated strategies for acoustic separation and
manipulation of cells and particles. Chem. Soc. Rev. 36, 492–506 (2007)
16. Lenshof, A., Ahmad-Tajudin, A., Jarås, K., Sward-Nilsson, A.M., Åberg, L., Marko-Varga, G.,
Laurell, T.: Acoustic whole blood plasmapheresis chip for prostate specific antigen microarray
diagnostics. Anal. Chem. 81(15), 6030–6037 (2009)
17. MacDonald, M.P., Spalding, G.C., Dholakia, K.: Microfluidic sorting in an optical lattice.
Nature 426, 421–424 (2003)
18. Huh, D., Bahng, J.H., Ling, Y., Wei, H.H., Kripfgans, O.D., Fowlkes, J.B., Grotberg,
J.B., Takayama, S.: Gravity-driven microfluidic particle sorting device with hydrodynamic
separation amplification. Anal. Chem. 79, 1369–1376 (2007)
19. Moorthy, J., Beebe, D.J.: In situ fabricated porous filters for microsystems. Lab Chip 3(2),
62–66 (2003)
20. Thorslund, S., Klett, O., Nikolajeff, F., Markides, K., Bergquist, J.: A hybrid poly (dimethylsiloxane) microsystem for on-chip whole blood filtration optimized for steroid screening.
Biomed. Microdevice 8(1), 73–79 (2006)
21. Wang, S., Sarenac, D., Chen, M.H., Huang, S.H., Giguel, F.F., Kuritzkes, D.R., Demirci, U.:
Simple filter microchip for rapid separation of plasma and viruses from whole blood. Int. J.
Nanomed. 7, 5019 (2012)
22. Shim, J.S., Ahn, C.H.: An on-chip whole blood/plasma separator using heteropacked beads
at the inlet of a microchannel. Lab Chip 12(5), 863–866 (2012)
23. Aran, K., Fok, A., Sasso, L.A., Kamdar, N., Guan, Y., Sun, Q., Ündar, A., Zahn, J.D.: Microfiltration platform for continuous blood plasma protein extraction from whole blood during
cardiac surgery. Lab Chip 11(17), 2858–2868 (2011)
24. Sun, M., Khan, Z.S., Vanapalli, S.A.: Blood plasma separation in a long two-phase plug
flowing through disposable tubing. Lab Chip 12(24), 5225–5230 (2012)
25. Zhang, X.B., Wu, Z.Q., Wang, K., Zhu, J., Xu, J.J., Xia, X.H., Chen, H.Y.: Gravitational sedimentation induced blood delamination for continuous plasma separation on a microfluidics
chip. Anal. Chem. 84(8), 3780–3786 (2012)
26. Tachi, T., Kaji, N., Tokeshi, M., Baba, Y.: Simultaneous separation, metering, and dilution of
plasma from human whole blood in a microfluidic system. Anal. Chem. 81(8), 3194–3198
(2009)
27. Dimov, I.K., Basabe-Desmonts, L., Garcia-Cordero, J.L., Ross, B.M., Ricco, A.J., Lee, L.P.:
Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS). Lab Chip
11(5), 845–850 (2011)
28. Wu, Z., Hjort, K.: Microfluidic hydrodynamic cell separation: a review. Micro Nanosyst. 1(3),
181–192 (2009)
29. Davis, J.A., Inglis, D.W., Morton, K.J., Lawrence, D.A., Huang, L.R., Chou, S.Y., Sturm,
J.C., Austin, R.H.: Deterministic hydrodynamics: taking blood apart. Proc. Natl. Acad. Sci.
103(40), 14779–14784 (2006)
30. Kersaudy-Kerhoas, M., Kavanagh, D.M., Dhariwal, R.S., Campbell, C.J., Desmulliez, M.P.:
Validation of a blood plasma separation system by biomarker detection. Lab Chip 10(12),
1587–1595 (2010)
31. Maria, M.S., Rakesh, P.E., Chandra, T.S., Sen, A.K.: Capillary flow-driven microfluidic device
with wettability gradient and sedimentation effects for blood plasma separation. Sci. Rep. 7,
43457 (2017)
32. Yang, S., Ündar, A., Zahn, J.D.: A microfluidic device for continuous, real time blood plasma
separation. Lab Chip 6(7), 871–880 (2006)
33. Vella, S.J., Beattie, P., Cademartiri, R., Laromaine, A., Martinez, A.W., Phillips, S.T., Whitesides, G.M.: Measuring markers of liver function using a micropatterned paper device designed
for blood from a fingerstick. Anal. Chem. 84(6), 2883–2891 (2012)
34. Fahraeus, R.: The suspension stability of the blood. Physiol. Rev. 9, 241–274 (1929)
35. Fahraus, R., Lindqvist, T.: The viscosity of the blood in narrow capillary tubes. Am. J. Physiol.
(legacy content) 96, 562–568 (1931)
36. Barbee, J.H., Cokelet, G.R.: The Fahraeus effect. Microvasc. Res. 3, 6–16 (1971)
V. Laxmi et al.
15. Laurell, T., Petersson, F., Nilsson, A.: Chip integrated strategies for acoustic separation and
manipulation of cells and particles. Chem. Soc. Rev. 36, 492–506 (2007)
16. Lenshof, A., Ahmad-Tajudin, A., Jarås, K., Sward-Nilsson, A.M., Åberg, L., Marko-Varga, G.,
Laurell, T.: Acoustic whole blood plasmapheresis chip for prostate specific antigen microarray
diagnostics. Anal. Chem. 81(15), 6030–6037 (2009)
17. MacDonald, M.P., Spalding, G.C., Dholakia, K.: Microfluidic sorting in an optical lattice.
Nature 426, 421–424 (2003)
18. Huh, D., Bahng, J.H., Ling, Y., Wei, H.H., Kripfgans, O.D., Fowlkes, J.B., Grotberg,
J.B., Takayama, S.: Gravity-driven microfluidic particle sorting device with hydrodynamic
separation amplification. Anal. Chem. 79, 1369–1376 (2007)
19. Moorthy, J., Beebe, D.J.: In situ fabricated porous filters for microsystems. Lab Chip 3(2),
62–66 (2003)
20. Thorslund, S., Klett, O., Nikolajeff, F., Markides, K., Bergquist, J.: A hybrid poly (dimethylsiloxane) microsystem for on-chip whole blood filtration optimized for steroid screening.
Biomed. Microdevice 8(1), 73–79 (2006)
21. Wang, S., Sarenac, D., Chen, M.H., Huang, S.H., Giguel, F.F., Kuritzkes, D.R., Demirci, U.:
Simple filter microchip for rapid separation of plasma and viruses from whole blood. Int. J.
Nanomed. 7, 5019 (2012)
22. Shim, J.S., Ahn, C.H.: An on-chip whole blood/plasma separator using heteropacked beads
at the inlet of a microchannel. Lab Chip 12(5), 863–866 (2012)
23. Aran, K., Fok, A., Sasso, L.A., Kamdar, N., Guan, Y., Sun, Q., Ündar, A., Zahn, J.D.: Microfiltration platform for continuous blood plasma protein extraction from whole blood during
cardiac surgery. Lab Chip 11(17), 2858–2868 (2011)
24. Sun, M., Khan, Z.S., Vanapalli, S.A.: Blood plasma separation in a long two-phase plug
flowing through disposable tubing. Lab Chip 12(24), 5225–5230 (2012)
25. Zhang, X.B., Wu, Z.Q., Wang, K., Zhu, J., Xu, J.J., Xia, X.H., Chen, H.Y.: Gravitational sedimentation induced blood delamination for continuous plasma separation on a microfluidics
chip. Anal. Chem. 84(8), 3780–3786 (2012)
26. Tachi, T., Kaji, N., Tokeshi, M., Baba, Y.: Simultaneous separation, metering, and dilution of
plasma from human whole blood in a microfluidic system. Anal. Chem. 81(8), 3194–3198
(2009)
27. Dimov, I.K., Basabe-Desmonts, L., Garcia-Cordero, J.L., Ross, B.M., Ricco, A.J., Lee, L.P.:
Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS). Lab Chip
11(5), 845–850 (2011)
28. Wu, Z., Hjort, K.: Microfluidic hydrodynamic cell separation: a review. Micro Nanosyst. 1(3),
181–192 (2009)
29. Davis, J.A., Inglis, D.W., Morton, K.J., Lawrence, D.A., Huang, L.R., Chou, S.Y., Sturm,
J.C., Austin, R.H.: Deterministic hydrodynamics: taking blood apart. Proc. Natl. Acad. Sci.
103(40), 14779–14784 (2006)
30. Kersaudy-Kerhoas, M., Kavanagh, D.M., Dhariwal, R.S., Campbell, C.J., Desmulliez, M.P.:
Validation of a blood plasma separation system by biomarker detection. Lab Chip 10(12),
1587–1595 (2010)
31. Maria, M.S., Rakesh, P.E., Chandra, T.S., Sen, A.K.: Capillary flow-driven microfluidic device
with wettability gradient and sedimentation effects for blood plasma separation. Sci. Rep. 7,
43457 (2017)
32. Yang, S., Ündar, A., Zahn, J.D.: A microfluidic device for continuous, real time blood plasma
separation. Lab Chip 6(7), 871–880 (2006)
33. Vella, S.J., Beattie, P., Cademartiri, R., Laromaine, A., Martinez, A.W., Phillips, S.T., Whitesides, G.M.: Measuring markers of liver function using a micropatterned paper device designed
for blood from a fingerstick. Anal. Chem. 84(6), 2883–2891 (2012)
34. Fahraeus, R.: The suspension stability of the blood. Physiol. Rev. 9, 241–274 (1929)
35. Fahraus, R., Lindqvist, T.: The viscosity of the blood in narrow capillary tubes. Am. J. Physiol.
(legacy content) 96, 562–568 (1931)
36. Barbee, J.H., Cokelet, G.R.: The Fahraeus effect. Microvasc. Res. 3, 6–16 (1971)