442
M. Sakamoto
Fig. 21.5 Asymmetric synthesis followed by dynamic crystallization under achiral conditions
21.3.3 Asymmetric Synthesis of Amino Acid Derivatives
and Their Precursors
We also developed asymmetric amplification reactions combining the reversible
Michael addition reaction and the dynamic crystallization of conglomerate crystals (Fig. 21.6) [58]. Michael reaction of phenethylamine and aroylacrylamide 28 in
the presence of a catalytic amount of DBU in a mixed solvent of EtOH and heptane
Fig. 21.6 Asymmetric synthesis using reversible Michael addition followed by dynamic crystallization in achiral conditions
M. Sakamoto
Fig. 21.5 Asymmetric synthesis followed by dynamic crystallization under achiral conditions
21.3.3 Asymmetric Synthesis of Amino Acid Derivatives
and Their Precursors
We also developed asymmetric amplification reactions combining the reversible
Michael addition reaction and the dynamic crystallization of conglomerate crystals (Fig. 21.6) [58]. Michael reaction of phenethylamine and aroylacrylamide 28 in
the presence of a catalytic amount of DBU in a mixed solvent of EtOH and heptane
Fig. 21.6 Asymmetric synthesis using reversible Michael addition followed by dynamic crystallization in achiral conditions