Table 3 Crystal structure of the key druggable targets in Mtb
Molecular target
Pathways involved
PDB ID
DprE1
Arabinogalactan
biosynthesis
6G83, 5OEL, 5OEP, 5OEQ, 4CVY, 4P8C,
4P8 K, 4P8L, 4P8P, 4NCR
IspD
Arabinogalactan
biosynthesis
3OKR, 3Q7U, 3Q80, 2XWN
Antigen 85
complex
Mycolic acid synthesis
5OCJ, 5VNS, 4QDO, 4QDT, 4QDU,
3HRH
Pks13
Mycolic acid synthesis
6D8I, 6D8 J, 5XUO, 5V3 W, 5V3X
PcaA
Mycolic acid synthesis
1L1E
InhA
Mycolic acid synthesis
D,D-transpeptidase
Peptidoglycan
biosynthesis
5CRF, 5CXW, 4RYE
L,D transpeptidase-1
Peptidoglycan
biosynthesis
4JMN, 4JMX, 5E51, 5E5L
L,D transpeptidase-2
Peptidoglycan
biosynthesis
5DZP, 5DVP, 5D7H, 4GSU, 4GSR, 4GSQ,
4HU2, 4HUC, 3VAE, 3U1P, 3TX4, 3TUR
GlmU
Peptidoglycan
biosynthesis
2QKX
RmlC
Arabinogalactan
biosynthesis
2IXC, 1PM7
PknB
Signal transduction
6B2P, 6B2Q 5U94, 5E0Y, 5E0Z, 5E10,
5E12
PknG
Signal transduction
2PZI, 4Y0X, 4Y12
DevS
Regulatory process
2W3H, 2W3G, 2W3F, 2W3E, 4YOF,
4YNR
AspS
Protein synthesis
5W25
Peptide
Deformylase
Maturation of nascent
polypeptides
3E3U
DNA Gyrase
DNA replication
process
5BTN, 5BTL, 5BTI, 5BTG, 5BTF, 5BTD,
5BTC, 5BTA
RNA polymerase
Transcription process
5W36, 5W35, 5W33, 6C06, 6C05, 6C04
Isocitrate lyase
Carbon metabolism
6C4A, 6C4C, 5DQL
Malate synthase
Carbon metabolism
1N8I, 1N8 W, 4TVM
Lpd
Energy metabolism
4M52, 3II4
FtsZ
Cell division
1RQ7, 1RQ2, 1RLU, 2Q1X, 5V68
ClpP
Degradation of
damaged protein
4U0H, 2CE3
20S proteasome
Protein processing
2FHG
Glutamine
synthetase
Nitrogen metabolism
and cell wall
biosynthesis
1HTO, 1HTQ
Fumarate hydratase
Citric acid cycle
3NO9, 5F92, 5F91
MenB
Vitamin K2 synthesis
1Q52, 1Q51
MenD
Vitamin K2 synthesis
5ESD, 5ESO, 5ERY, 5ERX
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