Table 3
(continued)
Drug name
Chemical structure
Target
a
Disease condition
b
Reference
JQ1
O
Cl
N
N
S
N
N
BRD4
Suppresses cell growth and invasion in oral squamous
cell carcinoma, killing of MLL cells
[43, 44]
UNC669
N
O
N
N
Br
L3MBTL1
Effective and selective MBT inhibitor
[45]
a
EZH2 (enhancer of zeste homolog 2), p300 (P300 acetyltransferase), BRD4 (bromodomain-containing 4), DOT1L (disruptor of telomeric silencing-1 like),
L3MBTL1 (lethal(3)malignant brain tumor-like protein 1), MBT (malignant brain tumor)
b
DLBCL (diffuse large B cell lymphoma), NSCLC (non-small cell lung carcinoma cells), AML (acute myeloid leukemia), MLL (mixed lineage leukemia)
254
S. Loharch et al.