3 Modelling Simple Toxicity Endpoints …
47
Table 3.4
Skin sensitisation potency predictivity of the defined approach compared to both LLNA and human reference data
Benchmark data
Basketter potency category
GHS classification
n
Overpredicted
(%)
Correctly
predicted (%)
Underpredicted
(%)
n
Overpredicted
(%)
Correctly
predicted (%)
Underpredicted
(%)
DA vs. LLNA
174 20.1
58.6
21.3
174 12.1
73.0
14.9
DA vs. human
79 13.9
68.4
17.7
79 10.1
75.9
13.9
LLNA vs. human
89 24.7
53.9
21.3
79 20.2
65.2
14.6
47
Table 3.4
Skin sensitisation potency predictivity of the defined approach compared to both LLNA and human reference data
Benchmark data
Basketter potency category
GHS classification
n
Overpredicted
(%)
Correctly
predicted (%)
Underpredicted
(%)
n
Overpredicted
(%)
Correctly
predicted (%)
Underpredicted
(%)
DA vs. LLNA
174 20.1
58.6
21.3
174 12.1
73.0
14.9
DA vs. human
79 13.9
68.4
17.7
79 10.1
75.9
13.9
LLNA vs. human
89 24.7
53.9
21.3
79 20.2
65.2
14.6