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Table 3.3
Skin sensitisation hazard predictivity of individual test methods and the defined approach compared to both LLNA and human reference data
Test method
LLNA
Human
n
Accuracy (%) Sensitivity
(%)
Specificity
(%)
n
Accuracy (%) Sensitivity
(%)
Specificity
(%)
LLNA
–
–
–
–
108
80.6
88.0
63.6
DPRA
192
75.5
77.4
71.2
100
80.6
93.3
51.5
KeratinoSens™ 184
73.9
77.6
64.0
99
84.0
84.3
83.3
LuSens
77
75.3
77.1
72.4
60
82.8
81.7
85.7
h-CLAT
163
74.2
80.3
58.7
95
81.7
78.4
87.0
U-SENS™
123
82.9
92.3
56.3
91
81.1
88.6
60.0
Derek
210
83.3
92.6
61.3
108
80.6
88.0
63.6
Defined
approach
194
84.5
88.1
76.7
102
86.3
88.7
80.6