12 Application of Computational Methods for the Safety Assessment …
255
44. McLanahan ED, White P, Flowers L, Schlosser PM (2014) The use of PBPK models to inform
human health risk assessment: case study on perchlorate and radioiodide human lifestage
models. Risk Anal 34(2):356–366
45. Schlosser PM (2016) Revision of the affinity constant for perchlorate binding to the sodiumiodide symporter based on in vitro and human in vivo data. J Appl Toxicol 36(12):1531–1535
46. Aalberse RC, Stadler BM (2006) In silico predictability of allergenicity: from amino acid
sequence via 3-D structure to allergenicity. Mol Nutr Food Res 50(7):625–627
47. Commission CA. Guideline for the conduct of food safety assessment of foods derived from
recombinant-DNA plants. Annex on the Assessment of Possible Allergenicity. 2003 CAC/GL
45-2003
48. Commission CA (2009) Foods derived from modern biotechnology. Italy, Rome
49. Gendel SM (2009) Allergen databases and allergen semantics. Regul Toxicol Pharmacol 54(3
Suppl):S7–S10
50. Goodman RE, Ebisawa M, Ferreira F, Sampson HA, van Ree R, Vieths S, Baumert JL, Bohle
B, Lalithambika S, Wise J, Taylor SL (2016) AllergenOnline: a peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity. Mol Nutr Food Res
60(5):1183–1198
51. Choudhuri S (2004) Bioinformatics for beginners: genes, genomes, molecular evolution,
databases and analytical tools, London
52. Remington B, Broekman HCH, Blom WM, Capt A, Crevel RWR, Dimitrov I, Faeste CK,
Fernandez-Canton R, Giavi S, Houben GF, Glenn KC, Madsen CB, Kruizinga AK, Constable
A (2018) Approaches to assess IgE mediated allergy risks (sensitization and cross-reactivity)
from new or modified dietary proteins. Food Chem Toxicol 112:97–107
53. Herman RA, Song P, Thirumalaiswamysekhar A (2009) Value of eight-amino-acid matches in
predicting the allergenicity status of proteins: an empirical bioinformatic investigation. Clin
Mol Allergy 7:9
54. FAO/WHO (2001) Evaluation of allergenicity of genetically modified foods
55. Aalberse RC (2000) Structural biology of allergens. J Allergy Clin Immunol 106(2):228–238
56. Herman RA, Song P, Kumpatla S (2015) Percent amino-acid identity thresholds are not necessarily conservative for predicting allergenic cross-reactivity. Food Chem Toxicol 81:141–142
57. Cressman RF, Ladics G (2009) Further evaluation of the utility of “sliding window”
FASTA in predicting cross-reactivity with allergenic proteins. Regul Toxicol Pharmacol 54(3
Suppl):S20–S25
58. Ladics GS (2008) Current codex guidelines for assessment of potential protein allergenicity.
Food Chem Toxicol 46(Suppl 10):S20–S23
59. Benz RD, Irausquin H (1991) Priority-based assessment of food additives database of the U.S.
Food and Drug Administration Center for Food Safety and Applied Nutrition. Environ Health
Perspect 96:85–89
60. Cherkasov A, Muratov EN, Fourches D, Varnek A, Baskin II, Cronin M, Dearden J, Gramatica
P, Martin YC, Todeschini R, Consonni V, Kuz’min VE, Cramer R, Benigni R, Yang C, Rathman
J, Terfloth L, Gasteiger J, Richard A, Tropsha A (2014) QSAR modeling: where have you been?
Where are you going to? J Med Chem 57(12):4977–5010
61. Arvidson K, Rathman J, Volarath P, Mostrag A, Tarkhov A, Bienfait B, Vitcheva V, Yang C
(eds) Evaluation of the chemical inventories in the US FDA’s Office of Food Additive Safety
for human health endpoints using a toxicity prediction system. In: 55th Society of toxicology
annual meeting 2016, New Orleans, LA
62. FDA (2017) U.S. FDA Substances Added to Food Inventory (formerly EAFUS). https://www.
accessdata.fda.gov/scripts/fdcc/?set=FoodSubstances
63. FDA (2017) U.S. FDA inventory of effective food contact substance (FCS) notifications. https://
www.fda.gov/food/ingredientspackaginglabeling/packagingfcs/notifications/default.htm
64. FDA (2018) U.S. FDA inventory of GRAS notices. https://www.accessdata.fda.gov/scripts/
fdcc/?set=GRASNotices
65. FDA (2018) U.S. FDA List of Indirect Additives used in Food Contact substances. https://
www.fda.gov/food/ingredientspackaginglabeling/packagingfcs/indirectadditives/default.htm
255
44. McLanahan ED, White P, Flowers L, Schlosser PM (2014) The use of PBPK models to inform
human health risk assessment: case study on perchlorate and radioiodide human lifestage
models. Risk Anal 34(2):356–366
45. Schlosser PM (2016) Revision of the affinity constant for perchlorate binding to the sodiumiodide symporter based on in vitro and human in vivo data. J Appl Toxicol 36(12):1531–1535
46. Aalberse RC, Stadler BM (2006) In silico predictability of allergenicity: from amino acid
sequence via 3-D structure to allergenicity. Mol Nutr Food Res 50(7):625–627
47. Commission CA. Guideline for the conduct of food safety assessment of foods derived from
recombinant-DNA plants. Annex on the Assessment of Possible Allergenicity. 2003 CAC/GL
45-2003
48. Commission CA (2009) Foods derived from modern biotechnology. Italy, Rome
49. Gendel SM (2009) Allergen databases and allergen semantics. Regul Toxicol Pharmacol 54(3
Suppl):S7–S10
50. Goodman RE, Ebisawa M, Ferreira F, Sampson HA, van Ree R, Vieths S, Baumert JL, Bohle
B, Lalithambika S, Wise J, Taylor SL (2016) AllergenOnline: a peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity. Mol Nutr Food Res
60(5):1183–1198
51. Choudhuri S (2004) Bioinformatics for beginners: genes, genomes, molecular evolution,
databases and analytical tools, London
52. Remington B, Broekman HCH, Blom WM, Capt A, Crevel RWR, Dimitrov I, Faeste CK,
Fernandez-Canton R, Giavi S, Houben GF, Glenn KC, Madsen CB, Kruizinga AK, Constable
A (2018) Approaches to assess IgE mediated allergy risks (sensitization and cross-reactivity)
from new or modified dietary proteins. Food Chem Toxicol 112:97–107
53. Herman RA, Song P, Thirumalaiswamysekhar A (2009) Value of eight-amino-acid matches in
predicting the allergenicity status of proteins: an empirical bioinformatic investigation. Clin
Mol Allergy 7:9
54. FAO/WHO (2001) Evaluation of allergenicity of genetically modified foods
55. Aalberse RC (2000) Structural biology of allergens. J Allergy Clin Immunol 106(2):228–238
56. Herman RA, Song P, Kumpatla S (2015) Percent amino-acid identity thresholds are not necessarily conservative for predicting allergenic cross-reactivity. Food Chem Toxicol 81:141–142
57. Cressman RF, Ladics G (2009) Further evaluation of the utility of “sliding window”
FASTA in predicting cross-reactivity with allergenic proteins. Regul Toxicol Pharmacol 54(3
Suppl):S20–S25
58. Ladics GS (2008) Current codex guidelines for assessment of potential protein allergenicity.
Food Chem Toxicol 46(Suppl 10):S20–S23
59. Benz RD, Irausquin H (1991) Priority-based assessment of food additives database of the U.S.
Food and Drug Administration Center for Food Safety and Applied Nutrition. Environ Health
Perspect 96:85–89
60. Cherkasov A, Muratov EN, Fourches D, Varnek A, Baskin II, Cronin M, Dearden J, Gramatica
P, Martin YC, Todeschini R, Consonni V, Kuz’min VE, Cramer R, Benigni R, Yang C, Rathman
J, Terfloth L, Gasteiger J, Richard A, Tropsha A (2014) QSAR modeling: where have you been?
Where are you going to? J Med Chem 57(12):4977–5010
61. Arvidson K, Rathman J, Volarath P, Mostrag A, Tarkhov A, Bienfait B, Vitcheva V, Yang C
(eds) Evaluation of the chemical inventories in the US FDA’s Office of Food Additive Safety
for human health endpoints using a toxicity prediction system. In: 55th Society of toxicology
annual meeting 2016, New Orleans, LA
62. FDA (2017) U.S. FDA Substances Added to Food Inventory (formerly EAFUS). https://www.
accessdata.fda.gov/scripts/fdcc/?set=FoodSubstances
63. FDA (2017) U.S. FDA inventory of effective food contact substance (FCS) notifications. https://
www.fda.gov/food/ingredientspackaginglabeling/packagingfcs/notifications/default.htm
64. FDA (2018) U.S. FDA inventory of GRAS notices. https://www.accessdata.fda.gov/scripts/
fdcc/?set=GRASNotices
65. FDA (2018) U.S. FDA List of Indirect Additives used in Food Contact substances. https://
www.fda.gov/food/ingredientspackaginglabeling/packagingfcs/indirectadditives/default.htm