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Cheng Z, Cui W, Rogers HJ, Zhang Q, Jia C,
Yang Y, Tai P, Xie F, Liu W (2018) Roles of
MSH2 and MSH6 in cadmium-induced
G2/M checkpoint arrest in Arabidopsis
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017. Epub 2018 Mar 3
104. Song Y, Xiang F, Zhang G, Miao Y, Miao C,
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105. Wu G, Carville JS, Spalding EP (2016)
ABCB19-mediated polar auxin transport
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106. Hamdoun S, Zhang C, Gill M, Kumar N,
Churchman M, Larkin JC, Kwon A, Lu H
(2016) Differential roles of two homologous
cyclin-dependent kinase inhibitor genes in
regulating cell cycle and innate immunity in
Arabidopsis. Plant Physiol 170:515–527.
https://doi.org/10.1104/pp.15.01466
107. Yang L, Zhao X, Zhu H, Paul M, Zu Y, Tang
Z (2014) Exogenous trehalose largely alleviates ionic unbalance, ROS burst, and PCD
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eCollection 2014
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109. Efroni I, Ip P-L, Nawy T, Mello A, Birnbaum
KD (2015) Quantification of cell identity
from single-cell gene expression profiles.
Genome Biol 16:9
110. Efroni I, Mello A, Nawy T, Ip P-L, Rahni R,
DelRose N, Powers A, Satija R, Birnbaum KD
(2016) Root regeneration triggers an
embryo-like sequence guided by hormonal
interactions. Cell 165:1721–1733
111. Jean-Baptiste K, McFaline-Figueroa JL, Alexandre CM, Dorrity MW, Saunders L, Bubb
KL, Trapnell C, Fields S, Queitsch C,
Cuperus JT (2019) Dynamics of gene
expression in single root cells of Arabidopsis
thaliana. Plant Cell 31:993–1011
112. Brennecke P, Anders S, Kim JK, Kołodziejczyk AA, Zhang X, Proserpio V, Baying B,
Benes V, Teichmann SA, Marioni JC, Heisler
MG (2013) Accounting for technical noise in
single-cell RNA-seq experiments. Nat Methods 10:1093–1095
113. Rhee SY, Birnbaum KD, Ehrhardt DW
(2019) Towards building a plant cell atlas.
Trends Plant Sci 24:303–310. https://doi.
org/10.1016/j.tplants.2019.01.006303
114. Zhang T-Q, Xu Z-G, Shang G-D, Wang J-W
(2019) A single-cell RNA sequencing profiles
the developmental landscape of Arabidopsis
root. Mol Plant 12:648–660. https://doi.
org/10.1016/j.molp.2019.04.004
115. Denyer T, Ma X, Klesen S, Scacchi E,
Nieselt K, Timmermans MCP (2019) Spatiotemporal developmental trajectories in the
arabidopsis root revealed using highthroughput single-cell RNA sequencing.
Dev Cell 48:840. –852 e845
116. Ryu KH, Huang L, Kang HM, Schiefelbein J
(2019) Single-cell RNA sequencing resolves
molecular relationships among individual
plant cells. Plant Physiol 179:1444–1456
117. Shulse CN, Cole BJ, Ciobanu D, Lin J,
Yoshinaga Y, Gouran M, Turco GM, Zhu Y,
O’Malley RC, Brady SM, Dickel DE (2019)
High-throughput single-cell transcriptome
profiling of plant cell types. Cell Rep
27:2241–2247
118. Grindberg RV, Yee-Greenbaum JL, McConnell MJ, Novotny M, O’Shaughnessy AL,
Lambert GM, Arau ´ zo-Bravo MJ, Lee J,
Fishman M, Lin X, Robbins GE, Lin X,
Venepally P, Badger JH, Galbraith DW,
Gage FH, Lasken RS (2013) RNA-Seq from
single nuclei. Proc Natl Acad Sci U S A
110:19802–19807
119. Petersson SV, Linden P, Moritz T, Ljung K
(2015) Cell-type specific metabolic profiling
of Arabidopsis thaliana protoplasts as a tool
for plant systems biology. Metabolomics
11:1679–1689
120. Skene PJ, Henikoff JG, Henikoff S (2018)
Targeted in situ genome wide profiling with
high efficiency for low cell numbers. Nat Protoc 13:1006–1019
121. Liu YF, Chen XY, Zhang YQ, Liu J (2019)
Advancing single-cell proteomics and metabolomics with microfluidic technologies.
Analyst 144:846–858
122. Kato N, Reynolds D, Brown ML,
Boisdore M, Fujikawa Y, Morales A, Meisel
LA (2008) Multidimensional fluorescence
Flow Cytometry and Sorting in Arabidopsis
293
Front Plant Sci 9:322. https://doi.org/10.
3389/fpls.2018.00322
103. Cao X, Wang H, Zhuang D, Zhu H, Du Y,
Cheng Z, Cui W, Rogers HJ, Zhang Q, Jia C,
Yang Y, Tai P, Xie F, Liu W (2018) Roles of
MSH2 and MSH6 in cadmium-induced
G2/M checkpoint arrest in Arabidopsis
roots. Chemosphere 201:586–594. https://
doi.org/10.1016/j.chemosphere.2018.03.
017. Epub 2018 Mar 3
104. Song Y, Xiang F, Zhang G, Miao Y, Miao C,
Song CP (2016) Abscisic acid as an internal
integrator of multiple physiological processes
modulates leaf senescence onset in Arabidopsis thaliana. Front Plant Sci 7:181. https://
doi.org/10.3389/fpls.2016.00181. eCollection 2016
105. Wu G, Carville JS, Spalding EP (2016)
ABCB19-mediated polar auxin transport
modulates Arabidopsis hypocotyl elongation
and the endoreplication variant of the cell
cycle. Plant J 85:209–218. https://doi.org/
10.1111/tpj.13095. Epub 2016 Jan 5
106. Hamdoun S, Zhang C, Gill M, Kumar N,
Churchman M, Larkin JC, Kwon A, Lu H
(2016) Differential roles of two homologous
cyclin-dependent kinase inhibitor genes in
regulating cell cycle and innate immunity in
Arabidopsis. Plant Physiol 170:515–527.
https://doi.org/10.1104/pp.15.01466
107. Yang L, Zhao X, Zhu H, Paul M, Zu Y, Tang
Z (2014) Exogenous trehalose largely alleviates ionic unbalance, ROS burst, and PCD
occurrence induced by high salinity in Arabidopsis seedlings. Front Plant Sci 5:570.
https://doi.org/10.3389/fpls.2014.00570.
eCollection 2014
108. Hendrix S, Keunen E, Mertens AIG, Beemster GTS, Vangronsveld J, Cuypers A (2018)
Cell cycle regulation in different leaves of
Arabidopsis thaliana plants grown under control and cadmium-exposed conditions. Environ Exp Bot 155:441–452
109. Efroni I, Ip P-L, Nawy T, Mello A, Birnbaum
KD (2015) Quantification of cell identity
from single-cell gene expression profiles.
Genome Biol 16:9
110. Efroni I, Mello A, Nawy T, Ip P-L, Rahni R,
DelRose N, Powers A, Satija R, Birnbaum KD
(2016) Root regeneration triggers an
embryo-like sequence guided by hormonal
interactions. Cell 165:1721–1733
111. Jean-Baptiste K, McFaline-Figueroa JL, Alexandre CM, Dorrity MW, Saunders L, Bubb
KL, Trapnell C, Fields S, Queitsch C,
Cuperus JT (2019) Dynamics of gene
expression in single root cells of Arabidopsis
thaliana. Plant Cell 31:993–1011
112. Brennecke P, Anders S, Kim JK, Kołodziejczyk AA, Zhang X, Proserpio V, Baying B,
Benes V, Teichmann SA, Marioni JC, Heisler
MG (2013) Accounting for technical noise in
single-cell RNA-seq experiments. Nat Methods 10:1093–1095
113. Rhee SY, Birnbaum KD, Ehrhardt DW
(2019) Towards building a plant cell atlas.
Trends Plant Sci 24:303–310. https://doi.
org/10.1016/j.tplants.2019.01.006303
114. Zhang T-Q, Xu Z-G, Shang G-D, Wang J-W
(2019) A single-cell RNA sequencing profiles
the developmental landscape of Arabidopsis
root. Mol Plant 12:648–660. https://doi.
org/10.1016/j.molp.2019.04.004
115. Denyer T, Ma X, Klesen S, Scacchi E,
Nieselt K, Timmermans MCP (2019) Spatiotemporal developmental trajectories in the
arabidopsis root revealed using highthroughput single-cell RNA sequencing.
Dev Cell 48:840. –852 e845
116. Ryu KH, Huang L, Kang HM, Schiefelbein J
(2019) Single-cell RNA sequencing resolves
molecular relationships among individual
plant cells. Plant Physiol 179:1444–1456
117. Shulse CN, Cole BJ, Ciobanu D, Lin J,
Yoshinaga Y, Gouran M, Turco GM, Zhu Y,
O’Malley RC, Brady SM, Dickel DE (2019)
High-throughput single-cell transcriptome
profiling of plant cell types. Cell Rep
27:2241–2247
118. Grindberg RV, Yee-Greenbaum JL, McConnell MJ, Novotny M, O’Shaughnessy AL,
Lambert GM, Arau ´ zo-Bravo MJ, Lee J,
Fishman M, Lin X, Robbins GE, Lin X,
Venepally P, Badger JH, Galbraith DW,
Gage FH, Lasken RS (2013) RNA-Seq from
single nuclei. Proc Natl Acad Sci U S A
110:19802–19807
119. Petersson SV, Linden P, Moritz T, Ljung K
(2015) Cell-type specific metabolic profiling
of Arabidopsis thaliana protoplasts as a tool
for plant systems biology. Metabolomics
11:1679–1689
120. Skene PJ, Henikoff JG, Henikoff S (2018)
Targeted in situ genome wide profiling with
high efficiency for low cell numbers. Nat Protoc 13:1006–1019
121. Liu YF, Chen XY, Zhang YQ, Liu J (2019)
Advancing single-cell proteomics and metabolomics with microfluidic technologies.
Analyst 144:846–858
122. Kato N, Reynolds D, Brown ML,
Boisdore M, Fujikawa Y, Morales A, Meisel
LA (2008) Multidimensional fluorescence
Flow Cytometry and Sorting in Arabidopsis
293