Madadi M, Tu Y, Abbas A (2017b) Recent status on enzymatic saccharification of lignocellulosic
biomass for bioethanol production. Electron J Biol 13(2):135–143
Malav MK, Prasad S, Kharia SK, Kumar S, Sheetal K, Kannojiya S (2017) Furfural and 5-HMF:
potent fermentation inhibitors and their removal techniques. Int J Curr Microbiol App Sci 6
(3):2060–2066
Martín C, Galbe M, Nilvebrant N-O, Jönsson LJ (2002) Comparison of the fermentability of
enzymatic hydrolyzates of sugarcane bagasse pretreated by steam explosion using different
impregnating agents. In: Biotechnology for fuels and chemicals. Springer, pp 699–716
Martín C, Klinke HB, Thomsen AB (2007) Wet oxidation as a pretreatment method for enhancing
the enzymatic convertibility of sugarcane bagasse. Enzyme Microb Technol 40(3):426–432
Martín C, García A, Schreiber A, Puls J, Saake B (2015) Combination of water extraction with
dilute-sulphuric acid pretreatment for enhancing the enzymatic hydrolysis of Jatropha curcas
shells. Ind Crop Prod 64:233–241
Menegazzo F, Ghedini E, Signoretto M (2018) 5-Hydroxymethylfurfural (HMF) production from
real biomasses. Molecules 23(9):2201
Michalska K, Miazek K, Krzystek L, Ledakowicz S (2012) Influence of pretreatment with Fenton’s
reagent on biogas production and methane yield from lignocellulosic biomass. Bioresour
Technol 119:72–78
Miura T, Lee S-H, Inoue S, Endo T (2012) Improvement of enzymatic saccharification of sugarcane
bagasse by dilute-alkali-catalyzed hydrothermal treatment and subsequent disk milling.
Bioresour Technol 105:95–99
Modig T, Lidén G, Taherzadeh MJ (2002) Inhibition effects of furfural on alcohol dehydrogenase,
aldehyde dehydrogenase and pyruvate dehydrogenase. Biochem J 363(3):769–776
Mosier N, Wyman C, Dale B, Elander R, Lee Y, Holtzapple M, Ladisch M (2005) Features of
promising technologies for pretreatment of lignocellulosic biomass. Bioresour Technol 96
(6):673–686
Narron RH, Kim H, H-m C, Jameel H, Park S (2016) Biomass pretreatments capable of enabling
lignin valorization in a biorefinery process. Curr Opin Biotechnol 38:39–46
Ndukwe JK, Aliyu GO, Onwosi CO, Chukwu KO, Ezugworie FN (2020) Mechanisms of weak
acid-induced stress tolerance in yeasts: Prospects for improved bioethanol production from
lignocellulosic biomass. Process Biochem 90:118–130
Nguyen DTT, Praveen P, Loh K-C (2018) Zymomonas mobilis immobilization in polymeric
membranes for improved resistance to lignocellulose-derived inhibitors in bioethanol fermentation. Biochem Eng J 140:29–37
Nichols NN, Dien BS, Guisado GM, López MJ (eds) (2005) Twenty-sixth symposium on biotechnology for fuels and chemicals. Humana Press, Totowa
Nichols NN, Sharma LN, Mowery RA, Chambliss CK, Van Walsum GP, Dien BS, Iten LB (2008)
Fungal metabolism of fermentation inhibitors present in corn stover dilute acid hydrolysate.
Enzyme Microb Technol 42(7):624–630
Nichols NN, Dien BS, Cotta MA (2010) Fermentation of bioenergy crops into ethanol using
biological abatement for removal of inhibitors. Bioresour Technol 101(19):7545–7550
Nigam J (2001) Ethanol production from wheat straw hemicellulose hydrolysate by Pichia stipitis. J
Biotechnol 87(1):17–27
Nitsos CK, Matis KA, Triantafyllidis KS (2013) Optimization of hydrothermal pretreatment of
lignocellulosic biomass in the bioethanol production process. ChemSusChem 6(1):110–122
Oshoma CE, Greetham D, Louis EJ, Smart KA, Phister TG, Powell C, Du C (2015) Screening of
non-Saccharomyces cerevisiae strains for tolerance to formic acid in bioethanol fermentation.
PLoS One 10:8
Palma M, Guerreiro JF, Sá-Correia I (2018) Adaptive response and tolerance to acetic acid in
Saccharomyces cerevisiae and Zygosaccharomyces bailii: a physiological genomics perspective. Front Microbiol 9:274
Palmqvist E, Hahn-Hägerdal B (2000) Fermentation of lignocellulosic hydrolysates. II: inhibitors
and mechanisms of inhibition. Bioresour Technol 74(1):25–33
5 Challenges in Bioethanol Production: Effect of Inhibitory Compounds
151
biomass for bioethanol production. Electron J Biol 13(2):135–143
Malav MK, Prasad S, Kharia SK, Kumar S, Sheetal K, Kannojiya S (2017) Furfural and 5-HMF:
potent fermentation inhibitors and their removal techniques. Int J Curr Microbiol App Sci 6
(3):2060–2066
Martín C, Galbe M, Nilvebrant N-O, Jönsson LJ (2002) Comparison of the fermentability of
enzymatic hydrolyzates of sugarcane bagasse pretreated by steam explosion using different
impregnating agents. In: Biotechnology for fuels and chemicals. Springer, pp 699–716
Martín C, Klinke HB, Thomsen AB (2007) Wet oxidation as a pretreatment method for enhancing
the enzymatic convertibility of sugarcane bagasse. Enzyme Microb Technol 40(3):426–432
Martín C, García A, Schreiber A, Puls J, Saake B (2015) Combination of water extraction with
dilute-sulphuric acid pretreatment for enhancing the enzymatic hydrolysis of Jatropha curcas
shells. Ind Crop Prod 64:233–241
Menegazzo F, Ghedini E, Signoretto M (2018) 5-Hydroxymethylfurfural (HMF) production from
real biomasses. Molecules 23(9):2201
Michalska K, Miazek K, Krzystek L, Ledakowicz S (2012) Influence of pretreatment with Fenton’s
reagent on biogas production and methane yield from lignocellulosic biomass. Bioresour
Technol 119:72–78
Miura T, Lee S-H, Inoue S, Endo T (2012) Improvement of enzymatic saccharification of sugarcane
bagasse by dilute-alkali-catalyzed hydrothermal treatment and subsequent disk milling.
Bioresour Technol 105:95–99
Modig T, Lidén G, Taherzadeh MJ (2002) Inhibition effects of furfural on alcohol dehydrogenase,
aldehyde dehydrogenase and pyruvate dehydrogenase. Biochem J 363(3):769–776
Mosier N, Wyman C, Dale B, Elander R, Lee Y, Holtzapple M, Ladisch M (2005) Features of
promising technologies for pretreatment of lignocellulosic biomass. Bioresour Technol 96
(6):673–686
Narron RH, Kim H, H-m C, Jameel H, Park S (2016) Biomass pretreatments capable of enabling
lignin valorization in a biorefinery process. Curr Opin Biotechnol 38:39–46
Ndukwe JK, Aliyu GO, Onwosi CO, Chukwu KO, Ezugworie FN (2020) Mechanisms of weak
acid-induced stress tolerance in yeasts: Prospects for improved bioethanol production from
lignocellulosic biomass. Process Biochem 90:118–130
Nguyen DTT, Praveen P, Loh K-C (2018) Zymomonas mobilis immobilization in polymeric
membranes for improved resistance to lignocellulose-derived inhibitors in bioethanol fermentation. Biochem Eng J 140:29–37
Nichols NN, Dien BS, Guisado GM, López MJ (eds) (2005) Twenty-sixth symposium on biotechnology for fuels and chemicals. Humana Press, Totowa
Nichols NN, Sharma LN, Mowery RA, Chambliss CK, Van Walsum GP, Dien BS, Iten LB (2008)
Fungal metabolism of fermentation inhibitors present in corn stover dilute acid hydrolysate.
Enzyme Microb Technol 42(7):624–630
Nichols NN, Dien BS, Cotta MA (2010) Fermentation of bioenergy crops into ethanol using
biological abatement for removal of inhibitors. Bioresour Technol 101(19):7545–7550
Nigam J (2001) Ethanol production from wheat straw hemicellulose hydrolysate by Pichia stipitis. J
Biotechnol 87(1):17–27
Nitsos CK, Matis KA, Triantafyllidis KS (2013) Optimization of hydrothermal pretreatment of
lignocellulosic biomass in the bioethanol production process. ChemSusChem 6(1):110–122
Oshoma CE, Greetham D, Louis EJ, Smart KA, Phister TG, Powell C, Du C (2015) Screening of
non-Saccharomyces cerevisiae strains for tolerance to formic acid in bioethanol fermentation.
PLoS One 10:8
Palma M, Guerreiro JF, Sá-Correia I (2018) Adaptive response and tolerance to acetic acid in
Saccharomyces cerevisiae and Zygosaccharomyces bailii: a physiological genomics perspective. Front Microbiol 9:274
Palmqvist E, Hahn-Hägerdal B (2000) Fermentation of lignocellulosic hydrolysates. II: inhibitors
and mechanisms of inhibition. Bioresour Technol 74(1):25–33
5 Challenges in Bioethanol Production: Effect of Inhibitory Compounds
151