Harmsen P, Huijgen W, Bermudez L, Bakker R (2010) Literature review of physical and chemical
pretreatment processes for lignocellulosic biomass. Wageningen UR-Food & Biobased
Research, Wageningen
Hasunuma T, Ismail KSK, Nambu Y, Kondo A (2014) Co-expression of TAL1 and ADH1 in
recombinant xylose-fermenting Saccharomyces cerevisiae improves ethanol production from
lignocellulosic hydrolysates in the presence of furfural. J Biosci Bioeng 117(2):165–169
Hawkins GM, Doran-Peterson J (2011) A strain of Saccharomyces cerevisiae evolved for fermentation of lignocellulosic biomass displays improved growth and fermentative ability in high
solids concentrations and in the presence of inhibitory compounds. Biotechnol Biofuels 4(1):49
Heipieper HJ, Weber FJ, Sikkema J, Keweloh H, de Bont JA (1994) Mechanisms of resistance of
whole cells to toxic organic solvents. Trends Biotechnol 12(10):409–415
Horn SJ, Nguyen QD, Westereng B, Nilsen PJ, Eijsink VG (2011) Screening of steam explosion
conditions for glucose production from non-impregnated wheat straw. Biomass Bioenergy 35
(12):4879–4886
Horváth IS, Taherzadeh MJ, Niklasson C, Lidén G (2001) Effects of furfural on anaerobic
continuous cultivation of Saccharomyces cerevisiae. Biotechnol Bioeng 75(5):540–549
Hou J, Tang J, Chen J, Zhang Q (2019) Quantitative structure-toxicity relationship analysis of
combined toxic effects of lignocellulose-derived inhibitors on bioethanol production. Bioresour
Technol 289:121724
Hsu T-A (1996) Pretreatment of biomass. In: Handbook on bioethanol, production and utilization.
CRC Press, Boca Raton, pp 179–212
Hu G, Heitmann JA, Rojas OJ (2008) Feedstock pretreatment strategies for producing ethanol from
wood, bark, and forest residues. BioResources 3(1):270–294
Ingle AP, Chandel AK, Antunes FA, Rai M, da Silva SS (2019) New trends in application of
nanotechnology for the pretreatment of lignocellulosic biomass. Biofuels Bioprod Biorefin 13
(3):776–788
Ito S, Sakai K, Gamaleev V, Ito M, Hori M, Kato M, Shimizu M (2020) Oxygen radical based on
non-thermal atmospheric pressure plasma alleviates lignin-derived phenolic toxicity in yeast.
Biotechnol Biofuels 13(1):1–13
Jacobsen SE, Wyman CE (eds) (2000) Twenty-first symposium on biotechnology for fuels and
chemicals. Humana Press, Totowa
Jędrzejczyk M, Soszka E, Czapnik M, Ruppert AM, Grams J (2019) Physical and chemical
pretreatment of lignocellulosic biomass. In: Second and third generation of feedstocks. Elsevier,
Amsterdam, pp 143–196
Ji G, Gao C, Xiao W, Han L (2016) Mechanical fragmentation of corncob at different plant scales:
impact and mechanism on microstructure features and enzymatic hydrolysis. Bioresour Technol
205:159–165
Jönsson LJ, Martín C (2016) Pretreatment of lignocellulose: formation of inhibitory by-products
and strategies for minimizing their effects. Bioresour Technol 199:103–112
Jönsson LJ, Alriksson B, Nilvebrant N-O (2013) Bioconversion of lignocellulose: inhibitors and
detoxification. Biotechnol Biofuels 6(1):16
Kang S, Fu J, Zhang G (2018) From lignocellulosic biomass to levulinic acid: a review on acidcatalyzed hydrolysis. Renew Sustain Energy Rev 94:340–362
Kim D (2018) Physico-chemical conversion of lignocellulose: Inhibitor effects and detoxification
strategies: a mini review. Molecules 23(2):309
Kim D-E, Pan X (2010) Preliminary study on converting hybrid poplar to high-value chemicals and
lignin using organosolv ethanol process. Industr Eng Chem Res 49(23):12156–12163
Kim Y, Ximenes E, Mosier NS, Ladisch MR (2011) Soluble inhibitors/deactivators of cellulase
enzymes from lignocellulosic biomass. Enzyme Microb Technol 48(4–5):408–415
Kim Y, Kreke T, Hendrickson R, Parenti J, Ladisch MR (2013) Fractionation of cellulase and
fermentation inhibitors from steam pretreated mixed hardwood. Bioresour Technol 135:30–38
Kim Y, Kreke T, Ko JK, Ladisch MR (2015) Hydrolysis-determining substrate characteristics in
liquid hot water pretreated hardwood. Biotechnol Bioeng 112(4):677–687
5 Challenges in Bioethanol Production: Effect of Inhibitory Compounds
149
pretreatment processes for lignocellulosic biomass. Wageningen UR-Food & Biobased
Research, Wageningen
Hasunuma T, Ismail KSK, Nambu Y, Kondo A (2014) Co-expression of TAL1 and ADH1 in
recombinant xylose-fermenting Saccharomyces cerevisiae improves ethanol production from
lignocellulosic hydrolysates in the presence of furfural. J Biosci Bioeng 117(2):165–169
Hawkins GM, Doran-Peterson J (2011) A strain of Saccharomyces cerevisiae evolved for fermentation of lignocellulosic biomass displays improved growth and fermentative ability in high
solids concentrations and in the presence of inhibitory compounds. Biotechnol Biofuels 4(1):49
Heipieper HJ, Weber FJ, Sikkema J, Keweloh H, de Bont JA (1994) Mechanisms of resistance of
whole cells to toxic organic solvents. Trends Biotechnol 12(10):409–415
Horn SJ, Nguyen QD, Westereng B, Nilsen PJ, Eijsink VG (2011) Screening of steam explosion
conditions for glucose production from non-impregnated wheat straw. Biomass Bioenergy 35
(12):4879–4886
Horváth IS, Taherzadeh MJ, Niklasson C, Lidén G (2001) Effects of furfural on anaerobic
continuous cultivation of Saccharomyces cerevisiae. Biotechnol Bioeng 75(5):540–549
Hou J, Tang J, Chen J, Zhang Q (2019) Quantitative structure-toxicity relationship analysis of
combined toxic effects of lignocellulose-derived inhibitors on bioethanol production. Bioresour
Technol 289:121724
Hsu T-A (1996) Pretreatment of biomass. In: Handbook on bioethanol, production and utilization.
CRC Press, Boca Raton, pp 179–212
Hu G, Heitmann JA, Rojas OJ (2008) Feedstock pretreatment strategies for producing ethanol from
wood, bark, and forest residues. BioResources 3(1):270–294
Ingle AP, Chandel AK, Antunes FA, Rai M, da Silva SS (2019) New trends in application of
nanotechnology for the pretreatment of lignocellulosic biomass. Biofuels Bioprod Biorefin 13
(3):776–788
Ito S, Sakai K, Gamaleev V, Ito M, Hori M, Kato M, Shimizu M (2020) Oxygen radical based on
non-thermal atmospheric pressure plasma alleviates lignin-derived phenolic toxicity in yeast.
Biotechnol Biofuels 13(1):1–13
Jacobsen SE, Wyman CE (eds) (2000) Twenty-first symposium on biotechnology for fuels and
chemicals. Humana Press, Totowa
Jędrzejczyk M, Soszka E, Czapnik M, Ruppert AM, Grams J (2019) Physical and chemical
pretreatment of lignocellulosic biomass. In: Second and third generation of feedstocks. Elsevier,
Amsterdam, pp 143–196
Ji G, Gao C, Xiao W, Han L (2016) Mechanical fragmentation of corncob at different plant scales:
impact and mechanism on microstructure features and enzymatic hydrolysis. Bioresour Technol
205:159–165
Jönsson LJ, Martín C (2016) Pretreatment of lignocellulose: formation of inhibitory by-products
and strategies for minimizing their effects. Bioresour Technol 199:103–112
Jönsson LJ, Alriksson B, Nilvebrant N-O (2013) Bioconversion of lignocellulose: inhibitors and
detoxification. Biotechnol Biofuels 6(1):16
Kang S, Fu J, Zhang G (2018) From lignocellulosic biomass to levulinic acid: a review on acidcatalyzed hydrolysis. Renew Sustain Energy Rev 94:340–362
Kim D (2018) Physico-chemical conversion of lignocellulose: Inhibitor effects and detoxification
strategies: a mini review. Molecules 23(2):309
Kim D-E, Pan X (2010) Preliminary study on converting hybrid poplar to high-value chemicals and
lignin using organosolv ethanol process. Industr Eng Chem Res 49(23):12156–12163
Kim Y, Ximenes E, Mosier NS, Ladisch MR (2011) Soluble inhibitors/deactivators of cellulase
enzymes from lignocellulosic biomass. Enzyme Microb Technol 48(4–5):408–415
Kim Y, Kreke T, Hendrickson R, Parenti J, Ladisch MR (2013) Fractionation of cellulase and
fermentation inhibitors from steam pretreated mixed hardwood. Bioresour Technol 135:30–38
Kim Y, Kreke T, Ko JK, Ladisch MR (2015) Hydrolysis-determining substrate characteristics in
liquid hot water pretreated hardwood. Biotechnol Bioeng 112(4):677–687
5 Challenges in Bioethanol Production: Effect of Inhibitory Compounds
149