References
1. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71–94
2. Shen P, Yue Y, Zheng J, Park Y (2018) Caenorhabditis elegans: a convenient in vivo model
for assessing the impact of food bioactive compounds on obesity, aging, and Alzheimer’s disease. Ann Rev Food Sci Technol 9:1–22
3. Kaletta T, Hengartner MO (2006) Finding
function in novel targets: C. elegans as a
model organism. Nat Rev Drug Discov
5:387–398
4. European Parliament and Council of the
European Union (2010) Directive 2010/63/
EU of the European Parliament and of the
Council of 22 September 2010 on the protection of animals used for scientific purposes.
Official J Eur Union 276:33–79. 32010L0063
5. U.S. Government Publishing Office (2013)
7 U.S.C., Chapter 54: Transportation, sale,
and handling of certain animals. https://www.
govinfo.gov/content/pkg/USCODE-2012title7/pdf/USCODE-2012-title7-chap54.pdf
6. Senate of Canada (2015) BILL S-214: An act
to amend the food and drugs act (cruelty-free
cosmetics).http://www.parl.ca/
DocumentViewer/en/42-1/bill/S-214/
third-reading
7. Zheng SQ, Ding AJ, Li GP et al (2013) Drug
absorption efficiency in Caenorhabditis elegans
delivered by different methods. PLoS One 8:
e56877
8. Kobet RA, Pan X, Zhang B et al (2014) Caenorhabditis elegans: a model system for anticancer drug discovery and therapeutic target
identification. Biomol Ther 22:371–383
9. Ganner A, Neumann-Haefelin E (2017)
Genetic kidney diseases: Caenorhabditis elegans
as model system. Cell Tissue Res 369:105–118
10. Pir GJ, Choudhary B, Mandelkow E (2017)
Caenorhabditis elegans models of tauopathy.
FASEB J 31:5137–5148
11. Martorell P, Bataller E, Llopis S et al (2013) A
cocoa peptide protects Caenorhabditis elegans
from oxidative stress and -amyloid peptide toxicity. PLoS One 8:e63283
12. Maglioni S, Ventura N (2016) C. elegans as a
model organism for human mitochondrial
associated
disorders.
Mitochondrion
30:117–125
13. Moreno-Arriola E, Cardenas-Rodriguez N,
Coballase-Urrutia E et al (2014) Caenorhabditis elegans: a useful model for studying metabolic disorders in which oxidative stress is a
contributing factor. Oxidative Med Cell
Longev 2014:705253. https://doi.org/10.
1155/2014/705253
14. Calvo DR, Martorell P, Genove ´s S et al (2016)
Development of novel functional ingredients:
need for testing systems and solutions with
Caenorhabditis elegans. Trends Food Sci Technol 54:197–203
15. Fischer N, Bu ¨chter C, Koch K et al (2017) The
resveratrol derivatives trans-3,5-dimethoxy-4fluoro-4
0 -hydroxystilbene and trans-2,4
0 ,5-trihydroxystilbene decrease oxidative stress and
prolong lifespan in Caenorhabditis elegans. J
Pharm Pharmacol 69:73–81
16. Saier C, Bu ¨chter C, Koch K et al (2018) Polygonum multiflorum extract exerts antioxidative
effects and increases life span and stress resistance in the model organism Caenorhabditis
elegans via DAF-16 and SIR-2.1. Plants 7:60.
https://doi.org/10.3390/plants7030060
17. Sanada Y, Asai S, Ikemoto A et al (2014) Oxidation resistance 1 is essential for protection
against oxidative stress and participates in the
regulation of aging in Caenorhabditis elegans.
Free Radic Res 48:919–928
18. Havermann S, Humpf HU, Watjen W (2016)
Baicalein modulates stress resistance and life
span in C. elegans via SKN-1 but not DAF-16.
Fitoterapia 113:123–127
19. Rodriguez-Concepcion M, Avalos J, Bonet
ML et al (2018) A global perspective on carotenoids: metabolism, biotechnology, and benefits for nutrition and health. Prog. Lipid Res
70:62–93
20. Barros MP, Rodrigo MJ, Zacarias L (2018)
Dietary carotenoid roles in redox homeostasis
and human health. J Agric Food Chem
66:5733–5740
21. Kaulmann A, Bohn T (2014) Carotenoids,
inflammation, and oxidative stress-implications
of cellular signaling pathways and relation to
chronic disease prevention. Nutr Res
34:907–929
22. Stahl W, Sies H (2005) Bioactivity and protective effects of natural carotenoids. Biochim
Biophys Acta Mol basis Dis 1740:101–107
23. Keith SA, Amrit FRG, Ratnappan R et al
(2014) The C. elegans healthspan and stressresistance assay toolkit. Methods 68:476–486
24. Li WH, Shi YC, Chang CH et al (2014) Selenite protects Caenorhabditis elegans from oxidative stress via DAF-16 and TRXR-1. Mol
Nutr Food Res 58(4):863–874
25. Can ˜uelo A, Gilbert-Lo ´pez B, Pacheco-Lin ˜a ´n P
et al (2012) Tyrosol, a main phenol present in
extra virgin olive oil, increases lifespan and
400
Patricia Martorell et al.
1. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71–94
2. Shen P, Yue Y, Zheng J, Park Y (2018) Caenorhabditis elegans: a convenient in vivo model
for assessing the impact of food bioactive compounds on obesity, aging, and Alzheimer’s disease. Ann Rev Food Sci Technol 9:1–22
3. Kaletta T, Hengartner MO (2006) Finding
function in novel targets: C. elegans as a
model organism. Nat Rev Drug Discov
5:387–398
4. European Parliament and Council of the
European Union (2010) Directive 2010/63/
EU of the European Parliament and of the
Council of 22 September 2010 on the protection of animals used for scientific purposes.
Official J Eur Union 276:33–79. 32010L0063
5. U.S. Government Publishing Office (2013)
7 U.S.C., Chapter 54: Transportation, sale,
and handling of certain animals. https://www.
govinfo.gov/content/pkg/USCODE-2012title7/pdf/USCODE-2012-title7-chap54.pdf
6. Senate of Canada (2015) BILL S-214: An act
to amend the food and drugs act (cruelty-free
cosmetics).http://www.parl.ca/
DocumentViewer/en/42-1/bill/S-214/
third-reading
7. Zheng SQ, Ding AJ, Li GP et al (2013) Drug
absorption efficiency in Caenorhabditis elegans
delivered by different methods. PLoS One 8:
e56877
8. Kobet RA, Pan X, Zhang B et al (2014) Caenorhabditis elegans: a model system for anticancer drug discovery and therapeutic target
identification. Biomol Ther 22:371–383
9. Ganner A, Neumann-Haefelin E (2017)
Genetic kidney diseases: Caenorhabditis elegans
as model system. Cell Tissue Res 369:105–118
10. Pir GJ, Choudhary B, Mandelkow E (2017)
Caenorhabditis elegans models of tauopathy.
FASEB J 31:5137–5148
11. Martorell P, Bataller E, Llopis S et al (2013) A
cocoa peptide protects Caenorhabditis elegans
from oxidative stress and -amyloid peptide toxicity. PLoS One 8:e63283
12. Maglioni S, Ventura N (2016) C. elegans as a
model organism for human mitochondrial
associated
disorders.
Mitochondrion
30:117–125
13. Moreno-Arriola E, Cardenas-Rodriguez N,
Coballase-Urrutia E et al (2014) Caenorhabditis elegans: a useful model for studying metabolic disorders in which oxidative stress is a
contributing factor. Oxidative Med Cell
Longev 2014:705253. https://doi.org/10.
1155/2014/705253
14. Calvo DR, Martorell P, Genove ´s S et al (2016)
Development of novel functional ingredients:
need for testing systems and solutions with
Caenorhabditis elegans. Trends Food Sci Technol 54:197–203
15. Fischer N, Bu ¨chter C, Koch K et al (2017) The
resveratrol derivatives trans-3,5-dimethoxy-4fluoro-4
0 -hydroxystilbene and trans-2,4
0 ,5-trihydroxystilbene decrease oxidative stress and
prolong lifespan in Caenorhabditis elegans. J
Pharm Pharmacol 69:73–81
16. Saier C, Bu ¨chter C, Koch K et al (2018) Polygonum multiflorum extract exerts antioxidative
effects and increases life span and stress resistance in the model organism Caenorhabditis
elegans via DAF-16 and SIR-2.1. Plants 7:60.
https://doi.org/10.3390/plants7030060
17. Sanada Y, Asai S, Ikemoto A et al (2014) Oxidation resistance 1 is essential for protection
against oxidative stress and participates in the
regulation of aging in Caenorhabditis elegans.
Free Radic Res 48:919–928
18. Havermann S, Humpf HU, Watjen W (2016)
Baicalein modulates stress resistance and life
span in C. elegans via SKN-1 but not DAF-16.
Fitoterapia 113:123–127
19. Rodriguez-Concepcion M, Avalos J, Bonet
ML et al (2018) A global perspective on carotenoids: metabolism, biotechnology, and benefits for nutrition and health. Prog. Lipid Res
70:62–93
20. Barros MP, Rodrigo MJ, Zacarias L (2018)
Dietary carotenoid roles in redox homeostasis
and human health. J Agric Food Chem
66:5733–5740
21. Kaulmann A, Bohn T (2014) Carotenoids,
inflammation, and oxidative stress-implications
of cellular signaling pathways and relation to
chronic disease prevention. Nutr Res
34:907–929
22. Stahl W, Sies H (2005) Bioactivity and protective effects of natural carotenoids. Biochim
Biophys Acta Mol basis Dis 1740:101–107
23. Keith SA, Amrit FRG, Ratnappan R et al
(2014) The C. elegans healthspan and stressresistance assay toolkit. Methods 68:476–486
24. Li WH, Shi YC, Chang CH et al (2014) Selenite protects Caenorhabditis elegans from oxidative stress via DAF-16 and TRXR-1. Mol
Nutr Food Res 58(4):863–874
25. Can ˜uelo A, Gilbert-Lo ´pez B, Pacheco-Lin ˜a ´n P
et al (2012) Tyrosol, a main phenol present in
extra virgin olive oil, increases lifespan and
400
Patricia Martorell et al.