Beneficial Microbes as Novel Microbial Cell …
329
microbes have been shown to have anticancer properties (Wu et al. 2016; Saxami
et al. 2017; Chondrou et al. 2018), whose efficacies can be improved through combination with nanotechnology. The nano-probiotic platforms among other things would
achieve improved diagnosis through imaging when coupled with nanoparticles such
as gold and enhanced therapy through the combined anticancer activities of nanoparticles and beneficial microbes or their products. The sensitivity and specificity of the
treatment would undoubtedly increase, while side effects can be reduced to the barest
minimum.
6 Conclusions and Future Prospects
In this short review, we considered the involvement of beneficial microbes, particularly bacteria in the green and ecofriendly synthesis of metallic nanoparticles.
Although, fewer numbers of these organisms have been reported so far for the biofabrication of nanoparticles, their active roles in nanobiotechnology are indisputably
a welcome development that would further enhance the safety of biosynthesized
nanoparticles for biomedical and food applications. Thus, the entrance of beneficial
microbes into the field of nanobiotechnology is expected to spur new lines of research
activities that would expand the roles of beneficial microbes at delivering novel products and services for mankind. It would be of interest for researches to evolve in the
areas of evaluation of biosafety and biocompatibility of beneficial microbes-mediated
nanoparticles, development of nano-based sensors, enhancement of antimicrobial
efficacy of metabolites such as nisin and bacteriocin in food applications, promotion of viability and stability of probiotics in the gut, improved nutrient and mineral
supplementation using nano-based platforms, drug delivery, anticancer activities and
more efficacious fermentative abilities of probiotics. Nanobiotechnology and beneficial microbes can be a launch pad of synergy to afford mankind the opportunity to
combat debilitating disorders that include Alzheimer’s and Parkinson’s diseases and
cancer.
Acknowledgements The authors are grateful to the authorities of LAUTECH, Ogbomoso, Nigeria,
for the provision of some of the facilities used in our works that are cited in this review.
References
Adelere IA, Lateef A (2016) A novel approach to the green synthesis of metallic nanoparticles:
the use of agro-wastes, enzymes and pigments. Nanotechnol Rev 5:567–587. https://doi.org/10.
1515/ntrev-2016-0024
Adelere IA, Lateef A, Aboyeji DO, Abdulsalam R, Adabara NU, Bala JD (2017) Biosynthesis of
silver nanoparticles using aqueous extract of Buchholzia coriacea (wonderful kola) seeds and
their antimicrobial activities. Ann Food Sci Technol 18:671–679
329
microbes have been shown to have anticancer properties (Wu et al. 2016; Saxami
et al. 2017; Chondrou et al. 2018), whose efficacies can be improved through combination with nanotechnology. The nano-probiotic platforms among other things would
achieve improved diagnosis through imaging when coupled with nanoparticles such
as gold and enhanced therapy through the combined anticancer activities of nanoparticles and beneficial microbes or their products. The sensitivity and specificity of the
treatment would undoubtedly increase, while side effects can be reduced to the barest
minimum.
6 Conclusions and Future Prospects
In this short review, we considered the involvement of beneficial microbes, particularly bacteria in the green and ecofriendly synthesis of metallic nanoparticles.
Although, fewer numbers of these organisms have been reported so far for the biofabrication of nanoparticles, their active roles in nanobiotechnology are indisputably
a welcome development that would further enhance the safety of biosynthesized
nanoparticles for biomedical and food applications. Thus, the entrance of beneficial
microbes into the field of nanobiotechnology is expected to spur new lines of research
activities that would expand the roles of beneficial microbes at delivering novel products and services for mankind. It would be of interest for researches to evolve in the
areas of evaluation of biosafety and biocompatibility of beneficial microbes-mediated
nanoparticles, development of nano-based sensors, enhancement of antimicrobial
efficacy of metabolites such as nisin and bacteriocin in food applications, promotion of viability and stability of probiotics in the gut, improved nutrient and mineral
supplementation using nano-based platforms, drug delivery, anticancer activities and
more efficacious fermentative abilities of probiotics. Nanobiotechnology and beneficial microbes can be a launch pad of synergy to afford mankind the opportunity to
combat debilitating disorders that include Alzheimer’s and Parkinson’s diseases and
cancer.
Acknowledgements The authors are grateful to the authorities of LAUTECH, Ogbomoso, Nigeria,
for the provision of some of the facilities used in our works that are cited in this review.
References
Adelere IA, Lateef A (2016) A novel approach to the green synthesis of metallic nanoparticles:
the use of agro-wastes, enzymes and pigments. Nanotechnol Rev 5:567–587. https://doi.org/10.
1515/ntrev-2016-0024
Adelere IA, Lateef A, Aboyeji DO, Abdulsalam R, Adabara NU, Bala JD (2017) Biosynthesis of
silver nanoparticles using aqueous extract of Buchholzia coriacea (wonderful kola) seeds and
their antimicrobial activities. Ann Food Sci Technol 18:671–679