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Topics in Current Chemistry (2020) 378:13
Table 1
Magnetic platforms based on DNA-conjugated iron oxide nanoparticles
APTES, 3-(Aminopropyl) triethoxysilane; PEI, polyethyleneimine; ssDNA, single-stranded DNA; CaP, calcium phosphate; PEG, polyethylene glycol; PAA, polyacrylic
acid; PDA, polydopamine
Magnetic nanoparticles
Synthetic method Coating agent
DNA interaction
Application
References
Fe
3 O
4
Co-precipitation
and reverse
microemulsion
APTES
Electrostatic adsorption
DNA exaction
[75]
Au-Fe
3 O
4 yolk-shell
Co-precipitation Thiolated DNA
Molecular recognition
Detection of mutated DNA
[76]
Graphene-coated iron nanoparticles (Fe/C) with a sulfonate
functionalization
–
PEI
Encapsulation
DNA storage
[77]
Fe
3 O
4 @SiO
2 @Au
Solvothermal
Labeled ssDNA
Covalent coupling
Gene detection
[78]
Fe
3 O
4 @SiO
2
Solvothermal
Silica
Adsorption
DNA extraction
[67]
Fe
3 O
4
Co-precipitation CaP and PEG-polyanion block
copolymers
Encapsulation (siRNA)
Gene delivery
[79]
Fe
3 O
4 coated with silica shell
Co-precipitation PAA–poly(PEG) block-copolymer
(PAA-b-PEGMA)
Covalent coupling
Detection of cancer biomarkers
[80]
Fe
3 O
4
Co-precipitation
and free radical
polymerization
PAA
Electrostatic adsorption
Specific adsorption of DNA
[81]
Fe
3 O
4
Hydrothermal
PDA
Glutaraldehyde cross-linking Immobilization of enzymes
[82]
Core–shell gold-coated magnetic
nanoparticles (Fe
3 O
4 -Au-NP)
Co-precipitation 5-Methyl cytosine antibody
(Abcam, Cambridge, UK)
Molecular recognition
DNA exaction for prenatal
diagnosis
[83]
25
Reprinted from the journal