1 3
Topics in Current Chemistry (2020) 378:8
28. Lauterbach A, Müller-Goymann CC (2015) Applications and limitations of lipid nanoparticles in
dermal and transdermal drug delivery via the follicular route. Eur J Pharm Biopharm 97:152–163.
https ://doi.org/10.1016/j.ejpb.2015.06.020
29. Vogt A, Wischke C, Neffe AT et al (2016) Nanocarriers for drug delivery into and through the
skin—do existing technologies match clinical challenges? J Control Release 242:3–15. https ://doi.
org/10.1016/j.jconr el.2016.07.027
30. Larese Filon F, Mauro M, Adami G et al (2015) Nanoparticles skin absorption: new aspects for
a safety profile evaluation. Regul Toxicol Pharmacol 72:310–322. https ://doi.org/10.1016/j.yrtph
.2015.05.005
31. Núñez-Lozano R, Cano M, Pimentel B, de la Cueva-Méndez G (2015) ‘Smartening’ anticancer therapeutic nanosystems using biomolecules. Curr Opin Biotechnol 35:135–140. https ://doi.
org/10.1016/j.copbi o.2015.07.005
32. Campbell CSJ, Contreras-Rojas LR, Delgado-Charro MB, Guy RH (2012) Objective assessment of
nanoparticle disposition in mammalian skin after topical exposure. J Control Release 162:201–207.
https ://doi.org/10.1016/j.jconr el.2012.06.024
33. Zhou Y, Damasceno PF, Somashekar BS et al (2018) Unusual multiscale mechanics of biomimetic
nanoparticle hydrogels. Nat Commun 9:181. https ://doi.org/10.1038/s4146 7-017-02579 -w
34. Larese FF, D’Agostin F, Crosera M et al (2009) Human skin penetration of silver nanoparticles
through intact and damaged skin. Toxicology 255:33–37. https ://doi.org/10.1016/j.tox.2008.09.025
35. Bianco C, Adami G, Crosera M et al (2014) Silver percutaneous absorption after exposure to silver
nanoparticles: a comparison study of three human skin graft samples used for clinical applications.
Burns 40:1390–1396. https ://doi.org/10.1016/j.burns .2014.02.003
36. Larese Filon F, Crosera M, Adami G et al (2011) Human skin penetration of gold nanoparticles
through intact and damaged skin. Nanotoxicology 5:493–501. https ://doi.org/10.3109/17435
390.2010.55142 8
37. Sonavane G, Tomoda K, Sano A et al (2008) In vitro permeation of gold nanoparticles through
rat skin and rat intestine: effect of particle size. Colloids Surf B Biointerfaces 65:1–10. https ://doi.
org/10.1016/j.colsu rfb.2008.02.013
38. Raju G, Katiyar N, Vadukumpully S, Shankarappa SA (2018) Penetration of gold nanoparticles across the stratum corneum layer of thick-Skin. J Dermatol Sci 89:146–154. https ://doi.
org/10.1016/j.jderm sci.2017.11.001
39. Rivera-Gil P, Jimenez De Aberasturi D, Wulf V et al (2013) The challenge to relate the physicochemical properties of colloidal nanoparticles to their cytotoxicity. Acc Chem Res 46:743–749.
https ://doi.org/10.1021/ar300 039j
40. Avci P, Sadasivam M, Gupta A et al (2013) Animal models of skin disease for drug discovery.
Expert Opin Drug Discov 8:331–355. https ://doi.org/10.1517/17460 441.2013.76120 2
41. Arora S, Jain J, Rajwade JM, Paknikar KM (2008) Cellular responses induced by silver nanoparticles: in vitro studies. Toxicol Lett 179:93–100. https ://doi.org/10.1016/j.toxle t.2008.04.009
42. Liu DC, Raphael AP, Sundh D et al (2012) The human stratum corneum prevents small gold nanoparticle penetration and their potential toxic metabolic consequences. J Nanomater 2012:1–8. https
://doi.org/10.1155/2012/72170 6
43. Cano M, Núñez-Lozano R, Lumbreras R et al (2017) Partial PEGylation of superparamagnetic iron
oxide nanoparticles thinly coated with amine-silane as a source of ultrastable tunable nanosystems
for biomedical applications. Nanoscale 9:812–822. https ://doi.org/10.1039/C6NR0 7462F
44. Grzelczak M, Pérez-Juste J, Mulvaney P, Liz-Marzán LM (2008) Shape control in gold nanoparticle
synthesis. Chem Soc Rev 37:1783. https ://doi.org/10.1039/b7114 90g
45. Hühn J, Carrillo-Carrion C, Soliman MG et al (2017) Selected standard protocols for the synthesis,
phase transfer, and characterization of inorganic colloidal nanoparticles. Chem Mater 29:399–461.
https ://doi.org/10.1021/acs.chemm ater.6b047 38
46. Sánchez-Iglesias A, Winckelmans N, Altantzis T et al (2017) High-yield seeded growth of monodisperse pentatwinned gold nanoparticles through thermally induced seed twinning. J Am Chem Soc
139:107–110. https ://doi.org/10.1021/jacs.6b121 43
47. Toy R, Peiris PM, Ghaghada KB, Karathanasis E (2014) Shaping cancer nanomedicine: the effect
of particle shape on the in vivo journey of nanoparticles. Nanomedicine 9:121–134. https ://doi.
org/10.2217/nnm.13.191
48. Blanco E, Shen H, Ferrari M (2015) Principles of nanoparticle design for overcoming biological
barriers to drug delivery. Nat Biotechnol 33:941–951. https ://doi.org/10.1038/nbt.3330
233
Reprinted from the journal
Topics in Current Chemistry (2020) 378:8
28. Lauterbach A, Müller-Goymann CC (2015) Applications and limitations of lipid nanoparticles in
dermal and transdermal drug delivery via the follicular route. Eur J Pharm Biopharm 97:152–163.
https ://doi.org/10.1016/j.ejpb.2015.06.020
29. Vogt A, Wischke C, Neffe AT et al (2016) Nanocarriers for drug delivery into and through the
skin—do existing technologies match clinical challenges? J Control Release 242:3–15. https ://doi.
org/10.1016/j.jconr el.2016.07.027
30. Larese Filon F, Mauro M, Adami G et al (2015) Nanoparticles skin absorption: new aspects for
a safety profile evaluation. Regul Toxicol Pharmacol 72:310–322. https ://doi.org/10.1016/j.yrtph
.2015.05.005
31. Núñez-Lozano R, Cano M, Pimentel B, de la Cueva-Méndez G (2015) ‘Smartening’ anticancer therapeutic nanosystems using biomolecules. Curr Opin Biotechnol 35:135–140. https ://doi.
org/10.1016/j.copbi o.2015.07.005
32. Campbell CSJ, Contreras-Rojas LR, Delgado-Charro MB, Guy RH (2012) Objective assessment of
nanoparticle disposition in mammalian skin after topical exposure. J Control Release 162:201–207.
https ://doi.org/10.1016/j.jconr el.2012.06.024
33. Zhou Y, Damasceno PF, Somashekar BS et al (2018) Unusual multiscale mechanics of biomimetic
nanoparticle hydrogels. Nat Commun 9:181. https ://doi.org/10.1038/s4146 7-017-02579 -w
34. Larese FF, D’Agostin F, Crosera M et al (2009) Human skin penetration of silver nanoparticles
through intact and damaged skin. Toxicology 255:33–37. https ://doi.org/10.1016/j.tox.2008.09.025
35. Bianco C, Adami G, Crosera M et al (2014) Silver percutaneous absorption after exposure to silver
nanoparticles: a comparison study of three human skin graft samples used for clinical applications.
Burns 40:1390–1396. https ://doi.org/10.1016/j.burns .2014.02.003
36. Larese Filon F, Crosera M, Adami G et al (2011) Human skin penetration of gold nanoparticles
through intact and damaged skin. Nanotoxicology 5:493–501. https ://doi.org/10.3109/17435
390.2010.55142 8
37. Sonavane G, Tomoda K, Sano A et al (2008) In vitro permeation of gold nanoparticles through
rat skin and rat intestine: effect of particle size. Colloids Surf B Biointerfaces 65:1–10. https ://doi.
org/10.1016/j.colsu rfb.2008.02.013
38. Raju G, Katiyar N, Vadukumpully S, Shankarappa SA (2018) Penetration of gold nanoparticles across the stratum corneum layer of thick-Skin. J Dermatol Sci 89:146–154. https ://doi.
org/10.1016/j.jderm sci.2017.11.001
39. Rivera-Gil P, Jimenez De Aberasturi D, Wulf V et al (2013) The challenge to relate the physicochemical properties of colloidal nanoparticles to their cytotoxicity. Acc Chem Res 46:743–749.
https ://doi.org/10.1021/ar300 039j
40. Avci P, Sadasivam M, Gupta A et al (2013) Animal models of skin disease for drug discovery.
Expert Opin Drug Discov 8:331–355. https ://doi.org/10.1517/17460 441.2013.76120 2
41. Arora S, Jain J, Rajwade JM, Paknikar KM (2008) Cellular responses induced by silver nanoparticles: in vitro studies. Toxicol Lett 179:93–100. https ://doi.org/10.1016/j.toxle t.2008.04.009
42. Liu DC, Raphael AP, Sundh D et al (2012) The human stratum corneum prevents small gold nanoparticle penetration and their potential toxic metabolic consequences. J Nanomater 2012:1–8. https
://doi.org/10.1155/2012/72170 6
43. Cano M, Núñez-Lozano R, Lumbreras R et al (2017) Partial PEGylation of superparamagnetic iron
oxide nanoparticles thinly coated with amine-silane as a source of ultrastable tunable nanosystems
for biomedical applications. Nanoscale 9:812–822. https ://doi.org/10.1039/C6NR0 7462F
44. Grzelczak M, Pérez-Juste J, Mulvaney P, Liz-Marzán LM (2008) Shape control in gold nanoparticle
synthesis. Chem Soc Rev 37:1783. https ://doi.org/10.1039/b7114 90g
45. Hühn J, Carrillo-Carrion C, Soliman MG et al (2017) Selected standard protocols for the synthesis,
phase transfer, and characterization of inorganic colloidal nanoparticles. Chem Mater 29:399–461.
https ://doi.org/10.1021/acs.chemm ater.6b047 38
46. Sánchez-Iglesias A, Winckelmans N, Altantzis T et al (2017) High-yield seeded growth of monodisperse pentatwinned gold nanoparticles through thermally induced seed twinning. J Am Chem Soc
139:107–110. https ://doi.org/10.1021/jacs.6b121 43
47. Toy R, Peiris PM, Ghaghada KB, Karathanasis E (2014) Shaping cancer nanomedicine: the effect
of particle shape on the in vivo journey of nanoparticles. Nanomedicine 9:121–134. https ://doi.
org/10.2217/nnm.13.191
48. Blanco E, Shen H, Ferrari M (2015) Principles of nanoparticle design for overcoming biological
barriers to drug delivery. Nat Biotechnol 33:941–951. https ://doi.org/10.1038/nbt.3330
233
Reprinted from the journal