1 3
Topics in Current Chemistry (2020) 378:8
Not only should the bond strength of the metal–ligand interaction be considered
but also the coating thickness and the degree of surface coverage. Previous studies
have demonstrated that polymeric capping ligands, such as poly(N-vinyl-2-pyrrolidone) (PVP), are well suited to stabilizing the surface of AuNPs for skin penetration, despite the weak metal–ligand interactions via pyrrolidone groups [56]. Huang
and co-workers [56] showed that water-soluble 5 nm PVP-capped AuNPs with a
spherical shape were mice skin permeable. They attributed this effect to the nanobio interaction with skin lipids, and the consequent induction of transient and reversible openings on the stratum corneum. In addition, they highlighted that co-administration of these PVP-capped AuNPs with protein drugs could enhance transdermal
drug delivery.
Fig. 3 Representative stabilizing ligand for plasmonic NPs
225
Reprinted from the journal
Topics in Current Chemistry (2020) 378:8
Not only should the bond strength of the metal–ligand interaction be considered
but also the coating thickness and the degree of surface coverage. Previous studies
have demonstrated that polymeric capping ligands, such as poly(N-vinyl-2-pyrrolidone) (PVP), are well suited to stabilizing the surface of AuNPs for skin penetration, despite the weak metal–ligand interactions via pyrrolidone groups [56]. Huang
and co-workers [56] showed that water-soluble 5 nm PVP-capped AuNPs with a
spherical shape were mice skin permeable. They attributed this effect to the nanobio interaction with skin lipids, and the consequent induction of transient and reversible openings on the stratum corneum. In addition, they highlighted that co-administration of these PVP-capped AuNPs with protein drugs could enhance transdermal
drug delivery.
Fig. 3 Representative stabilizing ligand for plasmonic NPs
225
Reprinted from the journal