Vol.:(0123456789)
Topics in Current Chemistry (2020) 378:8
https://doi.org/10.1007/s41061-019-0273-0
1 3
REVIEW
Bioconjugated Plasmonic Nanoparticles for Enhanced Skin
Penetration
David Alba‑Molina
1
· Juan J. Giner‑Casares
1
· Manuel Cano
1
Received: 7 November 2019 / Accepted: 3 December 2019 / Published online: 16 December 2019
© Springer Nature Switzerland AG 2019
Abstract
Plasmonic nanoparticles (NPs) are one of the most promising and studied inorganic
nanomaterials for different biomedical applications. Plasmonic NPs have excellent
biocompatibility, long-term stability against physical and chemical degradation, relevant optical properties, well-known synthesis methods and tuneable surface functionalities. Herein, we review recently reported bioconjugated plasmonic NPs using
different chemical approaches and loading cargoes (such as drugs, genes, and proteins) for enhancement of transdermal delivery across biological tissues. The main
aim is to understand the interaction of the complex skin structure with biomimetic
plasmonic NPs. This knowledge is not only important in enhancing transdermal
delivery of pharmaceutical formulations but also for controlling undesired skin penetration of industrial products, such as cosmetics, sunscreen formulations and any
other mass-usage consumable that contains plasmonic NPs.
Keywords Plasmonic nanoparticles · Transdermal drug delivery · Bioconjugated
nanomaterials · Skin penetration · Gold and silver nanoparticles
* Juan J. Giner-Casares
jjginer@uco.es
* Manuel Cano
q82calum@uco.es
1
Department of Physical Chemistry and Applied Thermodynamics, Institute of Nanochemistry
(IUNAN), University of Córdoba, Campus Universitario de Rabanales, Ed. Marie Curie,
14014 Córdoba, Spain
219
Reprinted from the journal
Chapter 7 was originally published as Alba‑Molina, D., Giner‑Casares, J. J. & Cano, M. Topics in
Current Chemistry (2020) 378: 8. https://doi.org/10.1007/s41061-019-0273-0.
Topics in Current Chemistry (2020) 378:8
https://doi.org/10.1007/s41061-019-0273-0
1 3
REVIEW
Bioconjugated Plasmonic Nanoparticles for Enhanced Skin
Penetration
David Alba‑Molina
1
· Juan J. Giner‑Casares
1
· Manuel Cano
1
Received: 7 November 2019 / Accepted: 3 December 2019 / Published online: 16 December 2019
© Springer Nature Switzerland AG 2019
Abstract
Plasmonic nanoparticles (NPs) are one of the most promising and studied inorganic
nanomaterials for different biomedical applications. Plasmonic NPs have excellent
biocompatibility, long-term stability against physical and chemical degradation, relevant optical properties, well-known synthesis methods and tuneable surface functionalities. Herein, we review recently reported bioconjugated plasmonic NPs using
different chemical approaches and loading cargoes (such as drugs, genes, and proteins) for enhancement of transdermal delivery across biological tissues. The main
aim is to understand the interaction of the complex skin structure with biomimetic
plasmonic NPs. This knowledge is not only important in enhancing transdermal
delivery of pharmaceutical formulations but also for controlling undesired skin penetration of industrial products, such as cosmetics, sunscreen formulations and any
other mass-usage consumable that contains plasmonic NPs.
Keywords Plasmonic nanoparticles · Transdermal drug delivery · Bioconjugated
nanomaterials · Skin penetration · Gold and silver nanoparticles
* Juan J. Giner-Casares
jjginer@uco.es
* Manuel Cano
q82calum@uco.es
1
Department of Physical Chemistry and Applied Thermodynamics, Institute of Nanochemistry
(IUNAN), University of Córdoba, Campus Universitario de Rabanales, Ed. Marie Curie,
14014 Córdoba, Spain
219
Reprinted from the journal
Chapter 7 was originally published as Alba‑Molina, D., Giner‑Casares, J. J. & Cano, M. Topics in
Current Chemistry (2020) 378: 8. https://doi.org/10.1007/s41061-019-0273-0.