Topics in Current Chemistry (2020) 378:35
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Examples of single and multiplexed fluorescence-based LFAs for a wide variety
of clinical relevant BMs using QD-hybrids (conjugated to protein or DNA) as signal
reporters can be found in the literature (Table 1) [120–128]. As shown in Table 1,
the use of QDs as labels in the development of LFAs has enabled the fast and sensitive determination of different protein biomarkers and DNA. The performance
Fig. 12 Quantum dot-based lateral flow assays (LFAs). a, b Schematic representation of the basic
structure of a LFA (a) and of a sandwich immunoassay format LFA (b). Reprinted from Bahadır and
Sezgintürk [115], copyright 2015, with permission from Elsevier. c Photograph of a portable fluorescence test strip reader and images of the QD-based fluorescence test strips with different concentrations
of the analyte (glutathione) together with the curves obtained from the reader. Reprinted from Liu et al.
[123], copyright 2018, with permission from Elsevier
154
Reprinted from the journal
1 3
Examples of single and multiplexed fluorescence-based LFAs for a wide variety
of clinical relevant BMs using QD-hybrids (conjugated to protein or DNA) as signal
reporters can be found in the literature (Table 1) [120–128]. As shown in Table 1,
the use of QDs as labels in the development of LFAs has enabled the fast and sensitive determination of different protein biomarkers and DNA. The performance
Fig. 12 Quantum dot-based lateral flow assays (LFAs). a, b Schematic representation of the basic
structure of a LFA (a) and of a sandwich immunoassay format LFA (b). Reprinted from Bahadır and
Sezgintürk [115], copyright 2015, with permission from Elsevier. c Photograph of a portable fluorescence test strip reader and images of the QD-based fluorescence test strips with different concentrations
of the analyte (glutathione) together with the curves obtained from the reader. Reprinted from Liu et al.
[123], copyright 2018, with permission from Elsevier
154
Reprinted from the journal