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Topics in Current Chemistry (2018) 376:46
The supported Ti-catalysts showed an extraordinary long-term stability, being active
for at least 1  year. The experiments were carried out under flow conditions using
the monolithic column functionalized with Ti–TADDOLate 65 bearing 2-naphtyl
groups at the α-positions.
Pericàs reported a polystyrene-supported analog of 3-exo-morpholinoisoborneol
67 synthesized and used as a ligand in the asymmetric alkylation of aldehydes with
Scheme 28 Anti-selective catalytic asymmetric nitroaldol reaction in flow
Scheme 29 Use of supported TADDOL in enantioselective addition of diethylzinc to benzaldehyde in
flow
Scheme 30 Continuous flow ethylation of benzaldehyde
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Reprinted from the journal