Topics in Current Chemistry (2018) 376:46
1 3
if a low level of metal can be lost, during operation with packed-bed reactors, the
“homeopathic” level of metal in solution can be enough to promote the chemical
process under investigation. Thus, it is expected that supported organometallic catalysts must be carefully designed in order to reduce as much as possible any leaching
of metal seldom precious and expensive.
In the context of palladium-catalyzed chemistry, Frost et al. developed two novel
polymer encapsulated silica-supported Pd(0) catalysts used in cross-coupling reactions under continuous flow conditions [60]. The key concept, developed by the
authors, was a simultaneously supported and encapsulated palladium nanoparticles
in order to obtain an efficient and robust palladium catalysts suitable for continuous
Scheme 20 Parallel kinetic resolution under continuous flow conditions. Adapted from ref. [56]
48
Reprinted from the journal
1 3
if a low level of metal can be lost, during operation with packed-bed reactors, the
“homeopathic” level of metal in solution can be enough to promote the chemical
process under investigation. Thus, it is expected that supported organometallic catalysts must be carefully designed in order to reduce as much as possible any leaching
of metal seldom precious and expensive.
In the context of palladium-catalyzed chemistry, Frost et al. developed two novel
polymer encapsulated silica-supported Pd(0) catalysts used in cross-coupling reactions under continuous flow conditions [60]. The key concept, developed by the
authors, was a simultaneously supported and encapsulated palladium nanoparticles
in order to obtain an efficient and robust palladium catalysts suitable for continuous
Scheme 20 Parallel kinetic resolution under continuous flow conditions. Adapted from ref. [56]
48
Reprinted from the journal