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Topics in Current Chemistry (2018) 376:46
FT–IR monitoring disclosing that (plot in Scheme  13) after the induction time,
under steady-state conditions, the reactor can be run for long time with the same
productivity and yield without compromising the activity of the catalyst with time.
The polystyrene-supported catalyst 27 bearing the 1,1′-binaphthol phosphoric
acid as catalytic moiety was reported by Pericàs and used in the enantioselective
Scheme 12 Use of supported organocatalyst in integrated flow system
Scheme 13 Use of SILLP in continuous flow synthesis. Adapted from Ref. [47]
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