Topics in Current Chemistry (2018) 376:44
1 3
narrower molecular weight distributions were achieved compared to the batch
operation. By assembling the integrated enzyme packed microreactor system, the
thiol-terminated PCL-b-PVL block copolymers were prepared through adjusting
the monomer introduction sequence [151]. Later, the enzymatic protecting-groupfree ring-opening polymerization and the radical polymerization or the nanoparticle
synthesis were integrated in this continuous-flow system, and amphiphilic poly(Nvinylpyrrolidone)-b-CL as well as poly(ε-caprolactone) protected silver nanoparticles were efficiently prepared [152].
In olefin metathesis reactions, the immobilization of homogeneous catalysts combines merits of both homogeneous and heterogeneous catalysis, but most supported
metathesis catalysts suffer from a loss of activity [153, 154]. Recently, Berlo et al.
Fig. 12 Synthesis of PPEGMA-b-PMMA diblock copolymer nanoparticles via polymerization-induced
self-assembly (PISA) in the continuous-flow tubular reactor with polymerization pathway (top view) and
schematic diagram of continuous-flow setup (bottom view). Reprinted with permission from [148]. Copyright (2017) Royal Society of Chemistry
176
Reprinted from the journal
1 3
narrower molecular weight distributions were achieved compared to the batch
operation. By assembling the integrated enzyme packed microreactor system, the
thiol-terminated PCL-b-PVL block copolymers were prepared through adjusting
the monomer introduction sequence [151]. Later, the enzymatic protecting-groupfree ring-opening polymerization and the radical polymerization or the nanoparticle
synthesis were integrated in this continuous-flow system, and amphiphilic poly(Nvinylpyrrolidone)-b-CL as well as poly(ε-caprolactone) protected silver nanoparticles were efficiently prepared [152].
In olefin metathesis reactions, the immobilization of homogeneous catalysts combines merits of both homogeneous and heterogeneous catalysis, but most supported
metathesis catalysts suffer from a loss of activity [153, 154]. Recently, Berlo et al.
Fig. 12 Synthesis of PPEGMA-b-PMMA diblock copolymer nanoparticles via polymerization-induced
self-assembly (PISA) in the continuous-flow tubular reactor with polymerization pathway (top view) and
schematic diagram of continuous-flow setup (bottom view). Reprinted with permission from [148]. Copyright (2017) Royal Society of Chemistry
176
Reprinted from the journal